TUB3 alpha-tubulin TUB3 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: TUB3
Official Full Name: alpha-tubulin TUB3
Primary source: SGD:S000004593
Locus tag: YML124C
See related: AllianceGenome:SGD:S000004593; FungiDB:YML124C; VEuPathDB:YML124C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: A structural constituent of cytoskeleton. Predicted to be involved in several processes, including microtubule cytoskeleton organization; nuclear division; and nuclear migration by microtubule mediated pushing forces. Located in spindle. Part of tubulin complex. Used to study several diseases, including Alzheimer's disease; leukemia; lissencephaly; lung carcinoma; and osteoblastoma. Human ortholog(s) of this gene implicated in several diseases, including Fanconi renotubular syndrome 3; amyotrophic lateral sclerosis type 22; keratoconus; lissencephaly (multiple); and visual epilepsy. Orthologous to several human genes including EHHADH (enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase); TUBA1A (tubulin alpha 1a); and TUBA1B (tubulin alpha 1b). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in homologous chromosome segregation	IC Inferred by Curator more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based process	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic sister chromatid segregation	IC Inferred by Curator more info	PubMed
involved_in nuclear division	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear migration along microtubule	IC Inferred by Curator more info	PubMed
involved_in nuclear migration by microtubule mediated pushing forces	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle	HDA more info	PubMed
is_active_in spindle	IBA Inferred from Biological aspect of Ancestor more info
part_of tubulin complex	IGI Inferred from Genetic Interaction more info	PubMed

NP_013582.1

Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication