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WSC3 Wsc3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854046, updated on 2-Nov-2024

Summary

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Official Symbol
WSC3
Official Full Name
Wsc3p
Primary source
SGD:S000005465
Locus tag
YOL105C
See related
AllianceGenome:SGD:S000005465; FungiDB:YOL105C; VEuPathDB:YOL105C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables transmembrane signaling receptor activity. Involved in Rho protein signal transduction; pexophagy; and response to heat. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See WSC3 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (114138..115808, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tRNA-Thr Neighboring gene Ndj1p Neighboring gene gag protein Neighboring gene gag-pol fusion protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tolerant industrial yeast Saccharomyces cerevisiae posses a more robust cell wall integrity signaling pathway against 2-furaldehyde and 5-(hydroxymethyl)-2-furaldehyde. Liu ZL, et al. J Biotechnol, 2018 Jun 20. PMID 29665400
  2. Distinct TORC1 signalling branches regulate Adc17 proteasome assembly chaperone expression. Williams TD, et al. J Cell Sci, 2024 Jul 15. PMID 38949052, Free PMC Article
  3. Characterization of the Wsc1 protein, a putative receptor in the stress response of Saccharomyces cerevisiae. Lodder AL, et al. Genetics, 1999 Aug. PMID 10430578, Free PMC Article
  4. Activation of signaling pathways related to cell wall integrity and multidrug resistance by organic solvent in Saccharomyces cerevisiae. Nishida N, et al. Curr Genet, 2014 Aug. PMID 24378717
  5. A novel role for the mating type (MAT) locus in the maintenance of cell wall integrity in Saccharomyces cerevisiae. Verna J, et al. Mol Gen Genet, 1999 Jun. PMID 10394905

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein Interactions of the Mechanosensory Proteins Wsc2 and Wsc3 for Stress Resistance in Saccharomyces cerevisiae.
    Title: Protein Interactions of the Mechanosensory Proteins Wsc2 and Wsc3 for Stress Resistance in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables transmembrane signaling receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in pexophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole HDA PubMed 
located_in mating projection tip HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Wsc3p
NP_014536.1
  • Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity; involved in response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis; WSC3 has a paralog, WSC2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    114138..115808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183359.1 → NP_014536.1  TPA: Wsc3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014536.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1W1, Q12215, Q2VQX5
    UniProtKB/TrEMBL
    A6ZNA4, B3LIV9, C7GRV7, N1P3Z3
    Conserved Domains (1) summary
    smart00321
    Location:39 → 132
    WSC; present in yeast cell wall integrity and stress response component proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12215.1

Gene LinkOut

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