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NUC1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853222, updated on 11-Sep-2024

Summary

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Official Symbol
NUC1
Primary source
SGD:S000003744
Locus tag
YJL208C
See related
AllianceGenome:SGD:S000003744; FungiDB:YJL208C; VEuPathDB:YJL208C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables endodeoxyribonuclease activity; exodeoxyribonuclease activity; and ribonuclease activity. Involved in defense response to virus and nucleic acid metabolic process. Located in cytosol; mitochondrial inner membrane; and nucleus. Orthologous to several human genes including ENDOG (endonuclease G). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (40194..41183, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene ubiquitin-protein ligase peroxin 2 Neighboring gene Cbp1p Neighboring gene Laa1p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Use of the nuc1 null mutant for analysis of yeast mitochondrial nucleoids. Miyakawa I, et al. J Gen Appl Microbiol, 2008 Dec. PMID 19164874
  2. Depletion of endonuclease G selectively kills polyploid cells. Büttner S, et al. Cell Cycle, 2007 May 2. PMID 17471024
  3. Analysis of the role of the NUC1 endo/exonuclease in yeast mitochondrial DNA recombination. Zassenhaus HP, et al. Curr Genet, 1994 Feb. PMID 8087883
  4. Purification and properties of the major nuclease from mitochondria of Saccharomyces cerevisiae. Dake E, et al. J Biol Chem, 1988 Jun 5. PMID 3286639
  5. Sequence and expression of NUC1, the gene encoding the mitochondrial nuclease in Saccharomyces cerevisiae. Vincent RD, et al. Nucleic Acids Res, 1988 Apr 25. PMID 2836792, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In this work, we show that budding yeast executes meiotically programmed mitochondrial release of an EndoG homolog, Nuc1, during sporulation
    Title: Meiotic viral attenuation through an ancestral apoptotic pathway.
  2. FSH3 induced apoptosis of yeast in a NUC1 dependent manner.
    Title: FSH3 mediated cell death is dependent on NUC1 in Saccharomyces cerevisiae.
  3. Nuc1p can efficiently trigger apoptotic cell death when excluded from mitochondria
    Title: Endonuclease G regulates budding yeast life and death.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA exonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA nuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA endodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in RNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in apoptotic DNA fragmentation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic DNA fragmentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ribonuclease
NP_012327.1
  • Major mitochondrial nuclease; has RNAse and DNA endo- and exonucleolytic activities; roles in mitochondrial recombination, apoptosis and maintenance of polyploidy; involved in fragmentation of genomic DNA during PND (programmed nuclear destruction); role in preventing L-A mycovirus pathogenesis; encodes ortholog of mammalian endoG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    40194..41183 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181641.1 → NP_012327.1  TPA: ribonuclease [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012327.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVY6, P08466
    UniProtKB/TrEMBL
    A6ZQD1, B3LPS2, B5VKY2, C7GUE6, C8ZB12, G2WGH2, N1P323
    Conserved Domains (1) summary
    COG1864
    Location:8 → 308
    NUC1; DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08466.1

Gene LinkOut

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