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DGAT2 diacylglycerol O-acyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 84649, updated on 2-Nov-2024

Summary

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Official Symbol
DGAT2provided by HGNC
Official Full Name
diacylglycerol O-acyltransferase 2provided by HGNC
Primary source
HGNC:HGNC:16940
See related
Ensembl:ENSG00000062282 MIM:606983; AllianceGenome:HGNC:16940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARAT; HMFN1045; GS1999FULL
Summary
This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Expression
Biased expression in fat (RPKM 381.0), liver (RPKM 87.8) and 1 other tissue See more
Orthologs
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Genomic context

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See DGAT2 in Genome Data Viewer
Location:
11q13.5
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (75768778..75801534)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (75698501..75731257)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (75479823..75512579)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 786, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5275 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:75479126-75479626 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3774 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3775 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5277 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:75487905-75488193 Neighboring gene DGAT2 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:75492457-75493023 Neighboring gene Sharpr-MPRA regulatory region 10576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3776 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5278 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:75524366-75525565 Neighboring gene Sharpr-MPRA regulatory region 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3777 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5280 Neighboring gene UVRAG divergent transcript Neighboring gene UV radiation resistance associated Neighboring gene Sharpr-MPRA regulatory region 15578 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:75584619-75585120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5281 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 1A pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Obesity promotes gastric cancer metastasis via diacylglycerol acyltransferase 2-dependent lipid droplets accumulation and redox homeostasis. Li S, et al. Redox Biol, 2020 Sep. PMID 32506038, Free PMC Article
  2. Expressional profiling of prostate cancer risk SNPs at 11q13.5 identifies DGAT2 as a new target gene. Nurminen R, et al. Genes Chromosomes Cancer, 2016 Aug. PMID 27113481
  3. Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2). Futatsugi K, et al. J Med Chem, 2015 Sep 24. PMID 26349027
  4. Diacylglycerol acyltransferase-2 contains a c-terminal sequence that interacts with lipid droplets. McFie PJ, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2018 Sep. PMID 29902571
  5. Mechanistic Characterization of Long Residence Time Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2). Pabst B, et al. Biochemistry, 2018 Dec 26. PMID 30422629

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DGAT2 stability is increased in response to DGAT1 inhibition in gene edited HepG2 cells.
    Title: DGAT2 stability is increased in response to DGAT1 inhibition in gene edited HepG2 cells.
  2. Diurnal expression of Dgat2 induced by time-restricted feeding maintains cardiac health in the Drosophila model of circadian disruption.
    Title: Diurnal expression of Dgat2 induced by time-restricted feeding maintains cardiac health in the Drosophila model of circadian disruption.
  3. The role of DGAT1 and DGAT2 in regulating tumor cell growth and their potential clinical implications.
    Title: The role of DGAT1 and DGAT2 in regulating tumor cell growth and their potential clinical implications.
  4. The roles of DGAT1 and DGAT2 in human myotubes are dependent on donor patho-physiological background.
    Title: The roles of DGAT1 and DGAT2 in human myotubes are dependent on donor patho-physiological background.
  5. Preferential lipolysis of DGAT1 over DGAT2 generated triacylglycerol in Huh7 hepatocytes.
    Title: Preferential lipolysis of DGAT1 over DGAT2 generated triacylglycerol in Huh7 hepatocytes.
  6. DGAT2 Inhibition Potentiates Lipid Droplet Formation To Reduce Cytotoxicity in APOL1 Kidney Risk Variants.
    Title: DGAT2 Inhibition Potentiates Lipid Droplet Formation To Reduce Cytotoxicity in APOL1 Kidney Risk Variants.
  7. ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials.
    Title: ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials.
  8. Obesity promotes gastric cancer metastasis via diacylglycerol acyltransferase 2-dependent lipid droplets accumulation and redox homeostasis.
    Title: Obesity promotes gastric cancer metastasis via diacylglycerol acyltransferase 2-dependent lipid droplets accumulation and redox homeostasis.
  9. These data suggest that Dgat2 is an important regulator of HCC cell proliferation.
    Title: Dgat2 reduces hepatocellular carcinoma malignancy via downregulation of cell cycle-related gene expression.
  10. A binding assay utilizing (125)I-labeled imidazopyridine demonstrated that the level of imidazopyridine binding to DGAT2 mutant enzymes, H161A and H163A, dramatically decreased to 11-17% of that of the wild-type enzyme, indicating that these residues are critical for imidazopyridines to bind to DGAT2.
    Title: Mechanistic Characterization of Long Residence Time Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2).
Submit: New GeneRIF Correction See all GeneRIFs (32)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686A15125

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 2-acylglycerol O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol O-acyltransferase activity EXP
Inferred from Experiment
more info
 PubMed 
enables diacylglycerol O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables diacylglycerol O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables retinol O-fatty-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to oleic acid ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cholesterol homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in diacylglycerol biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in diacylglycerol metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fat pad development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fatty acid homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycerol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular triglyceride homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid storage ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in long-chain fatty-acyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in low-density lipoprotein particle clearance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in monoacylglycerol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of plasma lipoprotein particle levels ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in retinol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in triglyceride biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride biosynthetic process TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IC
Inferred by Curator
more info
 PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with lipid droplet ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
diacylglycerol O-acyltransferase 2
Names
acyl-CoA retinol O-fatty-acyltransferase
diacylglycerol O-acyltransferase homolog 2
diacylglycerol O-acyltransferase-like protein 2
diglyceride acyltransferase 2
NP_001240820.1
NP_115953.2
XP_011543606.1
XP_047283672.1
XP_054226179.1
XP_054226180.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046775.1 RefSeqGene

    Range
    5046..37802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001253891.2 → NP_001240820.1  diacylglycerol O-acyltransferase 2 isoform 2

    See identical proteins and their annotated locations for NP_001240820.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AI126704, AP001922, AP003031, AY780647
    Consensus CDS
    CCDS58162.1
    UniProtKB/TrEMBL
    S4R3S3
    Related
    ENSP00000365438.3, ENST00000376262.7
    Conserved Domains (1) summary
    pfam03982
    Location:49 → 345
    DAGAT; Diacylglycerol acyltransferase

  2. NM_032564.5 → NP_115953.2  diacylglycerol O-acyltransferase 2 isoform 1

    See identical proteins and their annotated locations for NP_115953.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AL834287, DB462004
    Consensus CDS
    CCDS31642.1
    UniProtKB/Swiss-Prot
    A6ND76, Q5U810, Q68CL3, Q68DJ0, Q8NDB7, Q96BS0, Q96PD7, Q9BYE5
    Related
    ENSP00000228027.6, ENST00000228027.12
    Conserved Domains (1) summary
    pfam03982
    Location:92 → 388
    DAGAT; Diacylglycerol acyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    75768778..75801534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545304.3 → XP_011543606.1  diacylglycerol O-acyltransferase 2 isoform X1

    Conserved Domains (1) summary
    pfam03982
    Location:62 → 358
    DAGAT; Diacylglycerol acyltransferase

  2. XM_047427716.1 → XP_047283672.1  diacylglycerol O-acyltransferase 2 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    75698501..75731257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370204.1 → XP_054226179.1  diacylglycerol O-acyltransferase 2 isoform X1

  2. XM_054370205.1 → XP_054226180.1  diacylglycerol O-acyltransferase 2 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96PD7.2 GenPept UniProtKB/Swiss-Prot:Q96PD7

Gene LinkOut

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