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CUL1 cullin 1 [ Homo sapiens (human) ]

Gene ID: 8454, updated on 3-Nov-2024

Summary

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Official Symbol
CUL1provided by HGNC
Official Full Name
cullin 1provided by HGNC
Primary source
HGNC:HGNC:2551
See related
Ensembl:ENSG00000055130 MIM:603134; AllianceGenome:HGNC:2551
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables ubiquitin ligase complex scaffold activity and ubiquitin protein ligase binding activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of canonical NF-kappaB signal transduction; and protein K48-linked ubiquitination. Located in plasma membrane. Part of Parkin-FBXW7-Cul1 ubiquitin ligase complex and SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 55.7), lymph node (RPKM 17.7) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See CUL1 in Genome Data Viewer
Location:
7q36.1
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (148697756..148801110)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (149879652..149982884)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (148394848..148498202)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene huntingtin interacting protein K pseudogene Neighboring gene acyl-CoA thioesterase 13 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr7:148388173-148388399 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26800 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:148396297-148397022 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:148469244-148470443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26801 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148479522-148480224 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:148480425-148481624 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:148495129-148496328 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:148504832-148505332 Neighboring gene RNA, U7 small nuclear 20 pseudogene Neighboring gene enhancer of zeste 2 polycomb repressive complex 2 subunit Neighboring gene Sharpr-MPRA regulatory region 2848 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:148580637-148581328 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18737 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18738 Neighboring gene uncharacterized LOC124901767

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cullin1 is a novel marker of poor prognosis and a potential therapeutic target in human breast cancer. Bai J, et al. Ann Oncol, 2013 Aug. PMID 23592700
  2. Aberrant expression pattern and location of cullin 1 are associated with the development of papillary carcinoma in thyroid and cyclin D1 expression. Do SI, et al. Endocr Pathol, 2014 Sep. PMID 24819753
  3. Cullin1 regulates proliferation, migration and invasion of glioma cells. Fan YC, et al. Med Oncol, 2014 Oct. PMID 25201578
  4. Cul1 expression is increased in early stages of human melanoma. Chen G, et al. Pigment Cell Melanoma Res, 2010 Aug. PMID 20518860
  5. [Effects of Cullin1 on the Biological Characteristics of Lung Adenocarcinoma
A549 and H1395 Cells]. Liu J, et al. Zhongguo Fei Ai Za Zhi, 2021 Feb 20. PMID 33478195, Free PMC Article

See all (635) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircCUL1 inhibits trophoblast cell migration and invasion and promotes cell autophagy by sponging hsa-miR-30e-3p in fetal growth restriction via the ANXA1/PI3K/AKT axis.
    Title: CircCUL1 inhibits trophoblast cell migration and invasion and promotes cell autophagy by sponging hsa-miR-30e-3p in fetal growth restriction via the ANXA1/PI3K/AKT axis.
  2. NNMT/1-MNA Promote Cell-Cycle Progression of Breast Cancer by Targeting UBC12/Cullin-1-Mediated Degradation of P27 Proteins.
    Title: NNMT/1-MNA Promote Cell-Cycle Progression of Breast Cancer by Targeting UBC12/Cullin-1-Mediated Degradation of P27 Proteins.
  3. The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer.
    Title: The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer.
  4. Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.
    Title: Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.
  5. A Comprehensive Assessment of Genetic and Epigenetic Alterations Identifies Frequent Variations Impacting Six Prototypic SCF Complex Members.
    Title: A Comprehensive Assessment of Genetic and Epigenetic Alterations Identifies Frequent Variations Impacting Six Prototypic SCF Complex Members.
  6. microRNA-377-3p inhibits osteosarcoma progression by targeting CUL1 and regulating Wnt/beta-catenin signaling pathway.
    Title: microRNA-377-3p inhibits osteosarcoma progression by targeting CUL1 and regulating Wnt/β-catenin signaling pathway.
  7. Reduced SKP1 and CUL1 expression underlies increases in Cyclin E1 and chromosome instability in cellular precursors of high-grade serous ovarian cancer.
    Title: Reduced SKP1 and CUL1 expression underlies increases in Cyclin E1 and chromosome instability in cellular precursors of high-grade serous ovarian cancer.
  8. [Effects of Cullin1 on the Biological Characteristics of Lung AdenocarcinomaA549 and H1395 Cells].
    Title: [Effects of Cullin1 on the Biological Characteristics of Lung Adenocarcinoma
A549 and H1395 Cells].
  9. Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.
    Title: Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.
  10. Abnormal Cullin1 neddylation-mediated p21 accumulation participates in the pathogenesis of recurrent spontaneous abortion by regulating trophoblast cell proliferation and differentiation.
    Title: Abnormal Cullin1 neddylation-mediated p21 accumulation participates in the pathogenesis of recurrent spontaneous abortion by regulating trophoblast cell proliferation and differentiation.
Submit: New GeneRIF Correction See all GeneRIFs (73)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with Cullin 1 (CUL1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC149834, MGC149835

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin ligase complex scaffold activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 PubMed 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in animal organ morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in intrinsic apoptotic signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein monoubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SCF ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of cullin-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IC
Inferred by Curator
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cullin-1
Names
CUL-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_065171.1 RefSeqGene

    Range
    6148..108355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1407

mRNA and Protein(s)

  1. NM_001370660.1 → NP_001357589.1  cullin-1

    Status: REVIEWED

    Source sequence(s)
    AC005229, AC006323
    Consensus CDS
    CCDS34772.1
    UniProtKB/Swiss-Prot
    D3DWG3, O60719, Q08AL6, Q13616, Q8IYW1
    UniProtKB/TrEMBL
    A0A090N7U0, A0A590UJ21, A0A590UJR3
    Related
    ENSP00000499277.1, ENST00000662716.1
    Conserved Domains (2) summary
    pfam00888
    Location:21 → 660
    Cullin; Cullin family
    pfam10557
    Location:706 → 767
    Cullin_Nedd8; Cullin protein neddylation domain

  2. NM_001370661.1 → NP_001357590.1  cullin-1

    Status: REVIEWED

    Source sequence(s)
    AC005229, AC006323
    Consensus CDS
    CCDS34772.1
    UniProtKB/Swiss-Prot
    D3DWG3, O60719, Q08AL6, Q13616, Q8IYW1
    UniProtKB/TrEMBL
    A0A090N7U0, A0A590UJ21, A0A590UJR3
    Related
    ENSP00000499255.1, ENST00000665936.1
    Conserved Domains (2) summary
    pfam00888
    Location:21 → 660
    Cullin; Cullin family
    pfam10557
    Location:706 → 767
    Cullin_Nedd8; Cullin protein neddylation domain

  3. NM_001370662.1 → NP_001357591.1  cullin-1

    Status: REVIEWED

    Source sequence(s)
    AC005229, AC006323
    Consensus CDS
    CCDS34772.1
    UniProtKB/Swiss-Prot
    D3DWG3, O60719, Q08AL6, Q13616, Q8IYW1
    UniProtKB/TrEMBL
    A0A090N7U0, A0A590UJ21, A0A590UJR3
    Related
    ENSP00000473318.1, ENST00000602748.5
    Conserved Domains (2) summary
    pfam00888
    Location:21 → 660
    Cullin; Cullin family
    pfam10557
    Location:706 → 767
    Cullin_Nedd8; Cullin protein neddylation domain

  4. NM_001370663.1 → NP_001357592.1  cullin-1

    Status: REVIEWED

    Source sequence(s)
    AC005229, AC006323
    Consensus CDS
    CCDS34772.1
    UniProtKB/Swiss-Prot
    D3DWG3, O60719, Q08AL6, Q13616, Q8IYW1
    UniProtKB/TrEMBL
    A0A090N7U0, A0A590UJ21, A0A590UJR3
    Related
    ENSP00000499398.1, ENST00000663044.1
    Conserved Domains (2) summary
    pfam00888
    Location:21 → 660
    Cullin; Cullin family
    pfam10557
    Location:706 → 767
    Cullin_Nedd8; Cullin protein neddylation domain

  5. NM_001370664.1 → NP_001357593.1  cullin-1

    Status: REVIEWED

    Source sequence(s)
    AC005229, AC006323
    Consensus CDS
    CCDS34772.1
    UniProtKB/Swiss-Prot
    D3DWG3, O60719, Q08AL6, Q13616, Q8IYW1
    UniProtKB/TrEMBL
    A0A090N7U0, A0A590UJ21, A0A590UJR3
    Conserved Domains (2) summary
    pfam00888
    Location:21 → 660
    Cullin; Cullin family
    pfam10557
    Location:706 → 767
    Cullin_Nedd8; Cullin protein neddylation domain

  6. NM_003592.3 → NP_003583.2  cullin-1

    See identical proteins and their annotated locations for NP_003583.2

    Status: REVIEWED

    Source sequence(s)
    AF062536, AK096163, CA945052
    Consensus CDS
    CCDS34772.1
    UniProtKB/Swiss-Prot
    D3DWG3, O60719, Q08AL6, Q13616, Q8IYW1
    UniProtKB/TrEMBL
    A0A090N7U0, A0A590UJ21, A0A590UJR3
    Related
    ENSP00000326804.3, ENST00000325222.9
    Conserved Domains (2) summary
    pfam00888
    Location:21 → 660
    Cullin; Cullin family
    pfam10557
    Location:706 → 767
    Cullin_Nedd8; Cullin protein neddylation domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    148697756..148801110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    149879652..149982884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13616.2 GenPept UniProtKB/Swiss-Prot:Q13616

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
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