Asah1 N-acylsphingosine amidohydrolase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Asah1provided by RGD
Official Full Name: N-acylsphingosine amidohydrolase 1provided by RGD
Primary source: RGD:621568
See related: Ensembl:ENSRNOG00000010034 AllianceGenome:RGD:621568
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Asah
Summary: Predicted to enable N-acylsphingosine amidohydrolase activity; nuclear receptor binding activity; and transcription corepressor activity. Involved in lung development and response to organic substance. Predicted to be located in extracellular space; lysosome; and nucleus. Human ortholog(s) of this gene implicated in Farber lipogranulomatosis; sphingolipidosis; and spinal muscular atrophy with progressive myoclonic epilepsy. Orthologous to human ASAH1 (N-acylsphingosine amidohydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 539.6), Adrenal (RPKM 529.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (57669927..57701349)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (50966404..50997827)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (53998604..54030006)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acylsphingosine amidohydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acylsphingosine amidohydrolase activity	IEA Inferred from Electronic Annotation more info
enables N-acylsphingosine amidohydrolase activity	ISO Inferred from Sequence Orthology more info
enables N-acylsphingosine amidohydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ceramidase activity	IEA Inferred from Electronic Annotation more info
enables fatty acid amide hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	ISO Inferred from Sequence Orthology more info
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISS Inferred from Sequence or Structural Similarity more info
involved_in ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in ceramide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in ceramide catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ceramide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ceramide catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in lung development	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of programmed necrotic cell death	IEA Inferred from Electronic Annotation more info
involved_in regulation of programmed necrotic cell death	ISO Inferred from Sequence Orthology more info
involved_in regulation of programmed necrotic cell death	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of steroid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of steroid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sphingosine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in sphingosine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in sphingosine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
NOT located_in early endosome	ISO Inferred from Sequence Orthology more info
NOT located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acid ceramidase

Names: AC; ACDase; N-acylethanolamine hydrolase ASAH1; N-acylsphingosine amidohydrolase (acid ceramidase) 1; acid CDase; acylsphingosine deacylase

NP_445859.2

EC 3.5.1.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053407.3 → NP_445859.2 acid ceramidase precursor

See identical proteins and their annotated locations for NP_445859.2

Status: PROVISIONAL

Source sequence(s)

BC061540

UniProtKB/Swiss-Prot

Q6P7S1, Q9EQJ6

UniProtKB/TrEMBL

A0A8L2Q768

Related

ENSRNOP00000013463.5, ENSRNOT00000013463.5

Conserved Domains (2) summary

cd01903
Location:133 → 377

Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...

pfam15508
Location:44 → 105

NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase