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Gjb6 gap junction protein, beta 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84403, updated on 2-Nov-2024

Summary

Official Symbol
Gjb6provided by RGD
Official Full Name
gap junction protein, beta 6provided by RGD
Primary source
RGD:621830
See related
EnsemblRapid:ENSRNOG00000022116 AllianceGenome:RGD:621830
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cx30; Cxnf
Summary
Predicted to enable cytoskeletal protein binding activity and gap junction channel activity involved in cell communication by electrical coupling. Involved in several processes, including cellular response to glucose stimulus; response to electrical stimulus; and response to lipopolysaccharide. Located in apical plasma membrane and gap junction. Biomarker of borna disease; status epilepticus; transient cerebral ischemia; ureteral obstruction; and visual epilepsy. Human ortholog(s) of this gene implicated in Clouston syndrome; autosomal dominant nonsyndromic deafness 3B; autosomal recessive nonsyndromic deafness 1A; autosomal recessive nonsyndromic deafness 1B; and ectodermal dysplasia. Orthologous to human GJB6 (gap junction protein beta 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 43.3) and Thymus (RPKM 41.6) See more
Orthologs
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Genomic context

See Gjb6 in Genome Data Viewer
Location:
15p12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (35400147..35410649, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (31284561..31294552, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (37400888..37411656, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene MLV-related proviral Env polyprotein-like Neighboring gene gap junction protein, beta 2 Neighboring gene ribosomal protein L23A like 4 Neighboring gene uncharacterized LOC134482123

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables gap junction channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables gap junction channel activity ISO
Inferred from Sequence Orthology
more info
 
enables gap junction channel activity involved in cell communication by electrical coupling ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in actin filament ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
part_of connexin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in gap junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in gap junction ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
gap junction beta-6 protein
Names
connexin f
gap junction membrane channel protein beta 6
gap junction protein, beta 6 (connexin 30)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393806.1NP_001380735.1  gap junction beta-6 protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A6KHB2, A6KHB3, Q6AZ42, Q9R140
    Related
    ENSRNOP00000071038.1, ENSRNOT00000081757.3
    Conserved Domains (1) summary
    pfam00029
    Location:2215
    Connexin
  2. NM_053388.2NP_445840.2  gap junction beta-6 protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A6KHB2, A6KHB3, Q6AZ42, Q9R140
    Conserved Domains (1) summary
    pfam00029
    Location:2215
    Connexin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    35400147..35410649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274731.1XP_063130801.1  gap junction beta-6 protein isoform X1

    UniProtKB/TrEMBL
    A6KHB2, A6KHB3, Q6AZ42
  2. XM_006252080.5XP_006252142.1  gap junction beta-6 protein isoform X1

    See identical proteins and their annotated locations for XP_006252142.1

    UniProtKB/TrEMBL
    A6KHB2, A6KHB3, Q6AZ42, Q9R140
    Related
    ENSRNOP00000108582.1, ENSRNOT00000139621.1
    Conserved Domains (1) summary
    pfam00029
    Location:2215
    Connexin