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Cd93 CD93 molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 84398, updated on 2-Nov-2024

Summary

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Official Symbol
Cd93provided by RGD
Official Full Name
CD93 moleculeprovided by RGD
Primary source
RGD:621251
See related
EnsemblRapid:ENSRNOG00000024799 AllianceGenome:RGD:621251
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ly68; C1qRp; C1qr1
Summary
Predicted to enable complement component C1q complex binding activity and signaling receptor activity. Predicted to be involved in angiogenesis and cell-cell adhesion. Predicted to be located in cell surface; cytoplasmic vesicle; and plasma membrane. Orthologous to human CD93 (CD93 molecule). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 632.7), Heart (RPKM 284.8) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cd93 in Genome Data Viewer
Location:
3q41
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (156345019..156351537, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (135891859..135898378, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (142778798..142783774, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene somatostatin receptor 4 Neighboring gene thrombomodulin Neighboring gene uncharacterized LOC103691916 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular and cellular properties of the rat AA4 antigen, a C-type lectin-like receptor with structural homology to thrombomodulin. Dean YD, et al. J Biol Chem, 2000 Nov 3. PMID 10934210
  2. Synergistic regulation of microglia differentiation by CD93 and integrin β1 in the rat pneumococcal meningitis model. Qiao N, et al. Immunol Lett, 2022 Dec. PMID 36336138
  3. Crosstalk between CD93, C1q and GIPC in the Regulation of Pneumococcal Meningitis Inflammation. Qiao N, et al. Ann Clin Lab Sci, 2022 Jul. PMID 36197773
  4. Identification of a receptor for neuropeptide VGF and its role in neuropathic pain. Chen YC, et al. J Biol Chem, 2013 Nov 29. PMID 24106277, Free PMC Article
  5. Structure of the third intracellular loop of the vasopressin V2 receptor and conformational changes upon binding to gC1qR. Bellot G, et al. J Mol Biol, 2009 May 8. PMID 19285506

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Synergistic regulation of microglia differentiation by CD93 and integrin beta1 in the rat pneumococcal meningitis model.
    Title: Synergistic regulation of microglia differentiation by CD93 and integrin β1 in the rat pneumococcal meningitis model.
  2. Crosstalk between CD93, C1q and GIPC in the Regulation of Pneumococcal Meningitis Inflammation.
    Title: Crosstalk between CD93, C1q and GIPC in the Regulation of Pneumococcal Meningitis Inflammation.
  3. These results indicate that gC1qR is the receptor for TLQP-21 and plays an important role in chronic pain through activation of macrophages
    Title: Identification of a receptor for neuropeptide VGF and its role in neuropathic pain.
  4. The authors observed that binding of gC1qR to the full-length receptor modifies the intrinsic tryptophan fluorescence binding curves of V2 to an antagonist.
    Title: Structure of the third intracellular loop of the vasopressin V2 receptor and conformational changes upon binding to gC1qR.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables complement component C1q complex binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
complement component C1q receptor
Names
C1q/MBL/SPA receptor
C1qR(p)
CD93 antigen
cell surface antigen AA4
complement component 1 q subcomponent receptor 1
lymphocyte antigen 68

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053383.4 → NP_445835.2  complement component C1q receptor precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q9ET61, Q9JIZ6
    UniProtKB/TrEMBL
    A6K7C0
    Related
    ENSRNOP00000089608.1, ENSRNOT00000076493.3
    Conserved Domains (5) summary
    smart00179
    Location:424 → 462
    EGF_CA; Calcium-binding EGF-like domain
    pfam00008
    Location:303 → 331
    EGF; EGF-like domain
    pfam12662
    Location:323 → 345
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:261 → 297
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl02432
    Location:30 → 183
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    156345019..156351537 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ET61.1 GenPept UniProtKB/Swiss-Prot:Q9ET61

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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