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Il18bp interleukin 18 binding protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 84388, updated on 2-Nov-2024

Summary

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Official Symbol
Il18bpprovided by RGD
Official Full Name
interleukin 18 binding proteinprovided by RGD
Primary source
RGD:620042
See related
EnsemblRapid:ENSRNOG00000020150 AllianceGenome:RGD:620042
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Igifbp
Summary
Predicted to enable interleukin-18 binding activity. Involved in cellular response to hydrogen peroxide; cellular response to tumor necrosis factor; and response to lipopolysaccharide. Located in extracellular space. Human ortholog(s) of this gene implicated in allergic contact dermatitis and myocardial infarction. Orthologous to human IL18BP (interleukin 18 binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 62.9), Heart (RPKM 54.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Il18bp in Genome Data Viewer
Location:
1q32
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (165784916..165787990, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (156372923..156374963, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (167091521..167095727, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 51 Neighboring gene nuclear mitotic apparatus protein 1 Neighboring gene uncharacterized LOC134483764 Neighboring gene ring finger protein 121 Neighboring gene Xrcc1 N-terminal domain containing 1 Neighboring gene transient receptor potential cation channel subfamily C member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interleukin-18/interleukin-18 binding protein signaling modulates atherosclerotic lesion development and stability. Mallat Z, et al. Circ Res, 2001 Sep 28. PMID 11577031
  2. Remifentanil Ameliorates Liver Ischemia-Reperfusion Injury Through Inhibition of Interleukin-18 Signaling. Liu X, et al. Transplantation, 2015 Oct. PMID 25919765
  3. Suppressive effects of interleukin-18 on liver function in rat liver allografts. Ono S, et al. J Surg Res, 2012 Jul. PMID 21962809
  4. Circulating concentrations of interleukin-18, interleukin-18 binding protein, and gamma interferon in patients with alcoholic hepatitis. Spahr L, et al. Liver Int, 2004 Dec. PMID 15566508
  5. Plasma levels of interleukin-18 and interleukin-18 binding protein are elevated in patients with chronic liver disease. Ludwiczek O, et al. J Clin Immunol, 2002 Nov. PMID 12462332

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Remifentanil protects the liver against I/R injury by modulating hepatic IL-18/IL-18BP balance and inhibiting IL-18 signaling
    Title: Remifentanil Ameliorates Liver Ischemia-Reperfusion Injury Through Inhibition of Interleukin-18 Signaling.
  2. This protein was isolated, cloned and characterized in cultured COS cells.
    Title: Rat interleukin-18 binding protein: cloning, expression, and characterization.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables interleukin-18 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-18 binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in T-helper 1 type immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in T-helper 1 type immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
interleukin-18-binding protein
Names
interferon gamma inducing factor binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053374.2 → NP_445826.2  interleukin-18-binding protein precursor

    See identical proteins and their annotated locations for NP_445826.2

    Status: VALIDATED

    Source sequence(s)
    AA925116, AF154569, CB809932, JAXUCZ010000001
    UniProtKB/TrEMBL
    A6I6Z8, Q9JLN2
    Conserved Domains (1) summary
    cl23951
    Location:49 → 171
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    165784916..165787990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275803.1 → XP_063131873.1  interleukin-18-binding protein isoform X2

  2. XM_008759805.4 → XP_008758027.1  interleukin-18-binding protein isoform X1

    UniProtKB/TrEMBL
    F7F5P4, Q9JLN2
    Related
    ENSRNOP00000027301.3, ENSRNOT00000027301.5
    Conserved Domains (1) summary
    cl23951
    Location:49 → 166
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

RNA

  1. XR_010058350.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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