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Kcnn1 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 [ Mus musculus (house mouse) ]

Gene ID: 84036, updated on 2-Nov-2024

Summary

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Official Symbol
Kcnn1provided by MGI
Official Full Name
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1provided by MGI
Primary source
MGI:MGI:1933993
See related
Ensembl:ENSMUSG00000002908 AllianceGenome:MGI:1933993
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SK1; SKCa1; KCa2.1
Summary
Enables calmodulin binding activity. Predicted to be involved in potassium ion transmembrane transport. Located in cytoplasm and plasma membrane. Is expressed in brain; heart; peripheral nervous system; and testis. Orthologous to human KCNN1 (potassium calcium-activated channel subfamily N member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 4.8), CNS E14 (RPKM 4.3) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Kcnn1 in Genome Data Viewer
Location:
8 B3.3; 8 34.27 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71295802..71318335, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70843158..70865691, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene interleukin 12 receptor, beta 1 Neighboring gene STARR-positive B cell enhancer ABC_E133 Neighboring gene arrestin domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E3780 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:73389712-73389895 Neighboring gene STARR-positive B cell enhancer ABC_E8242 Neighboring gene coiled-coil domain containing 124 Neighboring gene STARR-seq mESC enhancer starr_21801 Neighboring gene solute carrier family 5 (sodium iodide symporter), member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional importance of Ca2+-activated K+ channels for lysophosphatidic acid-induced microglial migration. Schilling T, et al. Eur J Neurosci, 2004 Mar. PMID 15066143
  2. ESRRG-controlled downregulation of KCNN1 in primary sensory neurons is required for neuropathic pain. Wang H, et al. JCI Insight, 2024 May 21. PMID 38912580, Free PMC Article
  3. Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in pilocarpine-treated epileptic rats. Oliveira MS, et al. Brain Res, 2010 Aug 12. PMID 20553876, Free PMC Article
  4. T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites. Cueni L, et al. Nat Neurosci, 2008 Jun. PMID 18488023
  5. Structure and complex transcription pattern of the mouse SK1 K(Ca) channel gene, KCNN1. Shmukler BE, et al. Biochim Biophys Acta, 2001 Mar 19. PMID 11267657

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ESRRG-controlled downregulation of KCNN1 in primary sensory neurons is required for neuropathic pain.
    Title: ESRRG-controlled downregulation of KCNN1 in primary sensory neurons is required for neuropathic pain.
  2. Dynamic coupling between TRPV4 and Ca(2+)-activated SK1/3 and IK1 K(+) channels plays a critical role in regulating the K(+)-secretory BK channel KCNMA1 in kidney collecting duct cells.
    Title: Dynamic coupling between TRPV4 and Ca(2+)-activated SK1/3 and IK1 K(+) channels plays a critical role in regulating the K(+)-secretory BK channel in kidney collecting duct cells.
  3. These data indicate an abnormal expression of SK channels and a possible dysfunction of these channels in pilocarpine-treated epileptic rats.
    Title: Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in pilocarpine-treated epileptic rats.
  4. SK1, -2, -3, and IK1 (SK4) are expressed in islet cells and insulin-secreting cells and are able to influence glucose-induced calcium responses, thereby regulating insulin secretion.
    Title: Small-conductance calcium-activated K+ channels are expressed in pancreatic islets and regulate glucose responses.
  5. At the cellular level, SK1-like immunoreactivity is primarily localized to somatic and dendritic structures in the mouse brain.
    Title: Comparative immunohistochemical distribution of three small-conductance Ca2+-activated potassium channel subunits, SK1, SK2, and SK3 in mouse brain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (5)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC115869

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables inward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables small conductance calcium-activated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small conductance calcium-activated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables small conductance calcium-activated potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
small conductance calcium-activated potassium channel protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363407.2 → NP_001350336.1  small conductance calcium-activated potassium channel protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC019302, AC162446
    Consensus CDS
    CCDS52578.1
    UniProtKB/Swiss-Prot
    Q5CZY7, Q6JXY1, Q99JA9, Q9EQR3
    UniProtKB/TrEMBL
    A0A140T8Q8
    Related
    ENSMUSP00000148544.2, ENSMUST00000212611.2
    Conserved Domains (3) summary
    pfam02888
    Location:382 → 457
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:94 → 201
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:289 → 368
    Ion_trans_2; Ion channel

  2. NM_001363408.2 → NP_001350337.1  small conductance calcium-activated potassium channel protein 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC019302, AC162446
    Consensus CDS
    CCDS90413.1
    UniProtKB/Swiss-Prot
    Q5CZY7, Q6JXY1, Q99JA9, Q9EQR3
    UniProtKB/TrEMBL
    A0A1D5RMB2
    Related
    ENSMUSP00000148705.3, ENSMUST00000212509.3
    Conserved Domains (4) summary
    smart01053
    Location:382 → 457
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:94 → 201
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:289 → 368
    Ion_trans_2; Ion channel
    pfam13600
    Location:461 → 494
    DUF4140; N-terminal domain of unknown function (DUF4140)

  3. NM_032397.4 → NP_115773.2  small conductance calcium-activated potassium channel protein 1 isoform a

    See identical proteins and their annotated locations for NP_115773.2

    Status: VALIDATED

    Source sequence(s)
    AC019302, AC162446
    Consensus CDS
    CCDS52578.1
    UniProtKB/Swiss-Prot
    Q5CZY7, Q6JXY1, Q99JA9, Q9EQR3
    UniProtKB/TrEMBL
    A0A140T8Q8
    Related
    ENSMUSP00000105705.4, ENSMUST00000110078.5
    Conserved Domains (3) summary
    pfam02888
    Location:382 → 457
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:94 → 201
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:289 → 368
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71295802..71318335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243866.1 → XP_030099726.1  small conductance calcium-activated potassium channel protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q5CZY7, Q6JXY1, Q99JA9, Q9EQR3
    UniProtKB/TrEMBL
    A0A140T8Q8
    Conserved Domains (3) summary
    pfam02888
    Location:382 → 457
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:94 → 201
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:289 → 368
    Ion_trans_2; Ion channel

  2. XM_030243865.1 → XP_030099725.1  small conductance calcium-activated potassium channel protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q5CZY7, Q6JXY1, Q99JA9, Q9EQR3
    UniProtKB/TrEMBL
    A0A140T8Q8
    Conserved Domains (3) summary
    pfam02888
    Location:382 → 457
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:94 → 201
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:289 → 368
    Ion_trans_2; Ion channel

  3. XM_006509808.5 → XP_006509871.1  small conductance calcium-activated potassium channel protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006509871.1

    UniProtKB/Swiss-Prot
    Q5CZY7, Q6JXY1, Q99JA9, Q9EQR3
    UniProtKB/TrEMBL
    A0A140T8Q8
    Conserved Domains (3) summary
    pfam02888
    Location:382 → 457
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:94 → 201
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:289 → 368
    Ion_trans_2; Ion channel

  4. XM_036154395.1 → XP_036010288.1  small conductance calcium-activated potassium channel protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q5CZY7, Q6JXY1, Q99JA9, Q9EQR3
    Conserved Domains (3) summary
    smart01053
    Location:352 → 420
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:94 → 201
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:289 → 351
    Ion_trans_2; Ion channel

  5. XM_006509806.3 → XP_006509869.2  small conductance calcium-activated potassium channel protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5CZY7, Q6JXY1, Q99JA9, Q9EQR3
    Conserved Domains (4) summary
    pfam02888
    Location:352 → 420
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:94 → 201
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:289 → 351
    Ion_trans_2; Ion channel
    pfam06160
    Location:396 → 460
    EzrA; Septation ring formation regulator, EzrA

RNA

  1. XR_003947357.2 RNA Sequence

  2. XR_870467.3 RNA Sequence

  3. XR_379049.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EQR3.2 GenPept UniProtKB/Swiss-Prot:Q9EQR3

Gene LinkOut

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