Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prkab1provided by RGD
Official Full Name: protein kinase AMP-activated non-catalytic subunit beta 1provided by RGD
Primary source: RGD:71057
See related: EnsemblRapid:ENSRNOG00000001142 AllianceGenome:RGD:71057
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein kinase binding activity. Predicted to be involved in several processes, including positive regulation of cold-induced thermogenesis; positive regulation of gene expression; and protein phosphorylation. Predicted to act upstream of or within nail development. Part of nucleotide-activated protein kinase complex. Orthologous to human PRKAB1 (protein kinase AMP-activated non-catalytic subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 184.7), Kidney (RPKM 175.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (46248971..46259487)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (40588140..40598673)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (46316298..46326789)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Studies determine the three-dimensional reconstruction and subunit organization of the full-length rat AMPK (alpha1beta1gamma1) through single-particle electron
Title: Structural insights into the architecture and allostery of full-length AMP-activated protein kinase.
the activities of AMP-activated protein kinase, protein kinase B, and mammalian target of rapamycin by limiting energy availability with 2-deoxyglucose
Title: Modulation of the activities of AMP-activated protein kinase, protein kinase B, and mammalian target of rapamycin by limiting energy availability with 2-deoxyglucose.
metformin and AMPK have a previously unrecognized role in regulating the circadian rhythm
Title: Activation of 5'-AMP-activated kinase with diabetes drug metformin induces casein kinase Iepsilon (CKIepsilon)-dependent degradation of clock protein mPer2.
X-ray diffraction data collected from a selenomethionine-substituted protein.X-ray data collected from a selenomethionine-substituted protein.
Title: Crystallization of the glycogen-binding domain of the AMP-activated protein kinase beta subunit and preliminary X-ray analysis.
the inhibition of hepatic gluconeogenesis by AMPK may, in part, be mediated by an immediate early gene response involving EGR1 and its target, DUSP4
Title: Inhibition of gluconeogenesis through transcriptional activation of EGR1 and DUSP4 by AMP-activated kinase.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to nutrient levels	ISO Inferred from Sequence Orthology more info
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nail development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
part_of nucleotide-activated protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleotide-activated protein kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of nucleotide-activated protein kinase complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 5'-AMP-activated protein kinase subunit beta-1

Names: 5'-AMP-activated protein kinase 40 kDa subunit; 5'-AMP-activated protein kinase, beta subunit; 5-AMP-activated protein kinase beta subunit; AMPK beta-1 chain; AMPK subunit beta-1; AMPKb; protein kinase, AMP-activated, beta 1 non-catalytic subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031976.2 → NP_114182.2 5'-AMP-activated protein kinase subunit beta-1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

P80386, Q63048

UniProtKB/TrEMBL

A6J1R4

Conserved Domains (2) summary

smart01010
Location:181 → 270

AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain

pfam16561
Location:78 → 161

AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

46248971..46259487

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006249481.5 → XP_006249543.1 5'-AMP-activated protein kinase subunit beta-1 isoform X1

See identical proteins and their annotated locations for XP_006249543.1

UniProtKB/Swiss-Prot

P80386, Q63048

UniProtKB/TrEMBL

A6J1R4

Related

ENSRNOP00000001508.1, ENSRNOT00000001508.5

Conserved Domains (2) summary

smart01010
Location:181 → 270

AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain

pfam16561
Location:78 → 161

AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase
XM_063271713.1 → XP_063127783.1 5'-AMP-activated protein kinase subunit beta-1 isoform X2

UniProtKB/TrEMBL

A6J1R5

Related

ENSRNOP00000101213.1, ENSRNOT00000134208.1