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Apba3 amyloid beta precursor protein binding family A member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83611, updated on 18-Sep-2024

Summary

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Official Symbol
Apba3provided by RGD
Official Full Name
amyloid beta precursor protein binding family A member 3provided by RGD
Primary source
RGD:620846
See related
EnsemblRapid:ENSRNOG00000020466 AllianceGenome:RGD:620846
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mint3
Summary
Enables amyloid-beta binding activity. Predicted to be involved in chemical synaptic transmission and negative regulation of catalytic activity. Predicted to act upstream of or within in utero embryonic development and regulation of gene expression. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm; dendritic spine; and plasma membrane. Orthologous to human APBA3 (amyloid beta precursor protein binding family A member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 117.7), Kidney (RPKM 112.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Apba3 in Genome Data Viewer
Location:
7q11
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9096936..9103457, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8446212..8451310, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11314468..11319540, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene cactin, spliceosome C complex subunit Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 gamma Neighboring gene tight junction protein 3 Neighboring gene mitochondrial ribosomal protein L54 Neighboring gene megakaryocyte-associated tyrosine kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Responses of slowly adapting type II afferent fibres in cat hairy skin to vibrotactile stimuli. Gynther BD, et al. J Physiol, 1992 Dec. PMID 1302262, Free PMC Article
  2. Mint 3: a ubiquitous mint isoform that does not bind to munc18-1 or -2. Okamoto M, et al. Eur J Cell Biol, 1998 Nov. PMID 9860131
  3. FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells. Hirose Y, et al. J Biol Chem, 2014 Jul 25. PMID 24867948, Free PMC Article
  4. Mint3 enhances the activity of hypoxia-inducible factor-1 (HIF-1) in macrophages by suppressing the activity of factor inhibiting HIF-1. Sakamoto T, et al. J Biol Chem, 2009 Oct 30. PMID 19726677, Free PMC Article
  5. Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family. Ho A, et al. J Neurosci, 2006 Dec 13. PMID 17167098, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells.
    Title: FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables amyloid-beta binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amyloid-beta binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
amyloid-beta A4 precursor protein-binding family A member 3
Names
adapter protein X11gamma
amyloid beta (A4) precursor protein-binding, family A, member 3
amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2)
mint-3
neuron-specific X11L2 protein
neuronal Munc18-1-interacting protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031781.1 → NP_113969.1  amyloid-beta A4 precursor protein-binding family A member 3

    See identical proteins and their annotated locations for NP_113969.1

    Status: PROVISIONAL

    Source sequence(s)
    AF029109
    UniProtKB/Swiss-Prot
    O70248
    Conserved Domains (2) summary
    cd00992
    Location:388 → 473
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:208 → 359
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    9096936..9103457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241020.4 → XP_006241082.1  amyloid-beta A4 precursor protein-binding family A member 3 isoform X2

    See identical proteins and their annotated locations for XP_006241082.1

    UniProtKB/Swiss-Prot
    B1WBQ3, O70248
    Conserved Domains (2) summary
    cd00992
    Location:388 → 473
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:208 → 359
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

  2. XM_006241018.4 → XP_006241080.1  amyloid-beta A4 precursor protein-binding family A member 3 isoform X1

    See identical proteins and their annotated locations for XP_006241080.1

    Conserved Domains (2) summary
    cd00992
    Location:388 → 473
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:208 → 359
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

  3. XM_039079956.2 → XP_038935884.1  amyloid-beta A4 precursor protein-binding family A member 3 isoform X2

    UniProtKB/Swiss-Prot
    B1WBQ3, O70248
    Related
    ENSRNOP00000027784.2, ENSRNOT00000027784.6
    Conserved Domains (2) summary
    cd00992
    Location:388 → 473
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:208 → 359
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

  4. XM_006241019.4 → XP_006241081.1  amyloid-beta A4 precursor protein-binding family A member 3 isoform X1

    See identical proteins and their annotated locations for XP_006241081.1

    Related
    ENSRNOP00000112214.1, ENSRNOT00000147990.1
    Conserved Domains (2) summary
    cd00992
    Location:388 → 473
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:208 → 359
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70248.2 GenPept UniProtKB/Swiss-Prot:O70248

Gene LinkOut

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