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Casp6 caspase 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83584, updated on 14-Nov-2024

Summary

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Symbol
Casp6provided by RGD
Full Name
caspase 6provided by RGD
Primary source
RGD:70967
See related
EnsemblRapid:ENSRNOG00000052613 AllianceGenome:RGD:70967
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mch2
Summary
Enables endopeptidase activity. Involved in several processes, including acute inflammatory response to non-antigenic stimulus; axonal fasciculation; and positive regulation of programmed cell death. Located in axon and neuronal cell body. Used to study status epilepticus. Biomarker of brain ischemia; endometritis; middle cerebral artery infarction; and prostate carcinoma. Human ortholog(s) of this gene implicated in ovarian carcinoma. Orthologous to human CASP6 (caspase 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 132.6), Liver (RPKM 128.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Casp6 in Genome Data Viewer
Location:
2q43
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (221140287..221152727)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (218466063..218478503)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (235341326..235353715)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene complement factor I Neighboring gene uncharacterized LOC120100942 Neighboring gene phospholipase A2, group XIIA Neighboring gene uncharacterized LOC134485965 Neighboring gene mitochondrial calcium uniporter dominant negative subunit beta Neighboring gene SEC24 homolog B, COPII coat complex component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of caspase-6 in rat blastocysts and its implication in the induction of apoptosis by high glucose. Hinck L, et al. Biol Reprod, 2003 May. PMID 12606487
  2. Temporal regulation of VEID-7-amino-4-trifluoromethylcoumarin cleavage activity and caspase-6 correlates with organelle loss during lens development. Foley JD, et al. J Biol Chem, 2004 Jul 30. PMID 15161922
  3. Interleukin-1 beta induces posttranslational carboxymethylation and alterations in subnuclear distribution of lamin B in insulin-secreting RINm5F cells. Veluthakal R, et al. Am J Physiol Cell Physiol, 2004 Oct. PMID 15201138
  4. A caspase-6 and anti-human epidermal growth factor receptor-2 (HER2) antibody chimeric molecule suppresses the growth of HER2-overexpressing tumors. Xu YM, et al. J Immunol, 2004 Jul 1. PMID 15210759
  5. Activation of caspases-3, -6, and -9 during finasteride treatment of benign prostatic hyperplasia. Bozec A, et al. J Clin Endocrinol Metab, 2005 Jan. PMID 15507514

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spinal caspase-6 contributes to remifentanil-induced hyperalgesia via regulating CCL21/CXCR3 pathway in rats.
    Title: Spinal caspase-6 contributes to remifentanil-induced hyperalgesia via regulating CCL21/CXCR3 pathway in rats.
  2. To evaluate an axon autonomous role of Casp6, study examined axon integrity following transection ex vivo, and analyzed the serial morphological fragmentation of neurofilament expression as a structural index of axonal degeneration. Adding a specific Casp6 inhibitor to the preparation delayed neurofilament fragmentation.
    Title: Caspase-6 is a Dispensable Enabler of Adult Mammalian Axonal Degeneration.
  3. Caspase-6 shows a time-dependent expression in PMNs, MNCs and FBCs during skin injury repair in rat.
    Title: [A study on the time-dependent expression of caspase-6 during repair of skin contusion in rats].
  4. Cyclophilin-A is involved in excitotoxin-induced caspase activation in rat neuronal B50 cells
    Title: Cyclophilin-A is involved in excitotoxin-induced caspase activation in rat neuronal B50 cells.
  5. Neuronal caspase-6 immunoreactivity was markedly upregulated within cortex and hippocampus in relation to bursts of polyspike paroxysmal discharges.
    Title: Expression and differential processing of caspases 6 and 7 in relation to specific epileptiform EEG patterns following limbic seizures.
  6. nuclear fragmentation in rat blastocysts is apparently mediated by the activation of caspase-6
    Title: Identification of caspase-6 in rat blastocysts and its implication in the induction of apoptosis by high glucose.
  7. Testosterone inhibits apoptosis in the ventral prostate by potentially targeting the transcriptional activity of effector caspase-6 genes (but not of casapase-8 gene) as well as the cleavage of procaspase-6 into active enzymes.
    Title: Caspase-3 and -6 expression and activation are targeted by hormone action in the rat ventral prostate during the apoptotic cell death process.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC93335

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in activation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in activation of innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in acute inflammatory response to non-antigenic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axonal fasciculation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to staurosporine IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to staurosporine ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in hepatocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in hepatocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in hepatocyte apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intrinsic apoptotic signaling pathway by p53 class mediator IEA
Inferred from Electronic Annotation
more info
  
involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lens development in camera-type eye IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of necroptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of necroptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of necroptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of retinal cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autoprocessing IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autoprocessing ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoprocessing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in pyroptotic inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in pyroptotic inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in pyroptotic inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
  
involved_in response to cytokine IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to gamma radiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to glucose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to iron ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to metal ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to testosterone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to toxic substance IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
caspase-6
Names
CASP-6
apoptotic protease Mch-2
NP_001258913.1
NP_113963.2
XP_017446624.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271984.1 → NP_001258913.1  caspase-6

    See identical proteins and their annotated locations for NP_001258913.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC078785, DY310578, FM068086
    UniProtKB/Swiss-Prot
    O35397
    UniProtKB/TrEMBL
    Q6AZ23
    Conserved Domains (1) summary
    smart00115
    Location:20 → 273
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

  2. NM_031775.3 → NP_113963.2  caspase-6

    See identical proteins and their annotated locations for NP_113963.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC078785, FM068086
    UniProtKB/Swiss-Prot
    O35397
    UniProtKB/TrEMBL
    Q6AZ23
    Conserved Domains (1) summary
    smart00115
    Location:20 → 273
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    221140287..221152727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017591135.2 → XP_017446624.1  caspase-6 isoform X1

    UniProtKB/Swiss-Prot
    O35397
    UniProtKB/TrEMBL
    F6Q5I5
    Related
    ENSRNOP00000013049.4, ENSRNOT00000013049.8
    Conserved Domains (1) summary
    smart00115
    Location:19 → 272
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35397.2 GenPept UniProtKB/Swiss-Prot:O35397

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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