Tktl1 transketolase-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tktl1provided by MGI
Official Full Name: transketolase-like 1provided by MGI
Primary source: MGI:MGI:1933244
See related: Ensembl:ENSMUSG00000031397 AllianceGenome:MGI:1933244
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable thiamine pyrophosphate binding activity and transketolase activity. Predicted to be located in cytosol. Is expressed in early conceptus and secondary oocyte. Orthologous to human TKTL1 (transketolase like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 2.7) and CNS E18 (RPKM 0.1) See more
Orthologs: human all
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Genomic context

Location:: X A7.3; X 37.83 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (73220865..73252104)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (74177259..74208498)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tktl1 is a gene that is expressed in testis that was identified in a genome-wide cDNA subtraction screen.
Title: An abundance of X-linked genes expressed in spermatogonia.
Germ-cell-specific sex-linked genes, like Tktl1, are subject to meiotic sex-chromosome inactivation (MSCI) during spermatogenesis.
Title: Differential expression of sex-linked and autosomal germ-cell-specific genes during spermatogenesis in the mouse.
TKTL1 plays a role during mucosal repair and restoration.
Title: Lack of transketolase-like (TKTL) 1 aggravates murine experimental colitis.
Transcripts highly enriched in ovary; gene identified as candidate female fertility factor.
Title: Genomewide discovery and classification of candidate ovarian fertility genes in the mouse.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G65223 (e-PCR)
- UniSTS:225891

RH126774 (e-PCR)
- UniSTS:209526

G65797 (e-PCR)
- UniSTS:225931

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables thiamine pyrophosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables transketolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transketolase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transketolase-like protein 1

Names: TK 2; transketolase 2

NP_113556.2

EC 2.2.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031379.2 → NP_113556.2 transketolase-like protein 1

See identical proteins and their annotated locations for NP_113556.2

Status: VALIDATED

Source sequence(s)

AF285571, AK029546, BX512243

Consensus CDS

CCDS30221.1

UniProtKB/Swiss-Prot

B1AYP0, Q684Q5, Q8CDU7, Q99MX0

Related

ENSMUSP00000010127.6, ENSMUST00000010127.12

Conserved Domains (4) summary

cd07033
Location:293 → 446

TPP_PYR_DXS_TK_like; Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins

PRK05899
Location:17 → 590

PRK05899; transketolase; Reviewed

pfam02780
Location:463 → 585

Transketolase_C; Transketolase, C-terminal domain

cl01629
Location:29 → 238

TPP_enzymes; Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and ...