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RNF146 ring finger protein 146 [ Homo sapiens (human) ]

Gene ID: 81847, updated on 2-Nov-2024

Summary

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Official Symbol
RNF146provided by HGNC
Official Full Name
ring finger protein 146provided by HGNC
Primary source
HGNC:HGNC:21336
See related
Ensembl:ENSG00000118518 MIM:612137; AllianceGenome:HGNC:21336
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables poly-ADP-D-ribose binding activity and ubiquitin-protein transferase activity. Involved in positive regulation of canonical Wnt signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in fat (RPKM 18.0), lung (RPKM 11.1) and 25 other tissues See more
Orthologs
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Genomic context

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See RNF146 in Genome Data Viewer
Location:
6q22.33
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (127266682..127288562)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (128455637..128477520)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (127587827..127609707)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377989 Neighboring gene R-spondin 3 Neighboring gene uncharacterized LOC124901398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17526 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25039 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17528 Neighboring gene uncharacterized LOC105377994 Neighboring gene ethylmalonyl-CoA decarboxylase 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:127653558-127654108 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:127654109-127654658 Neighboring gene RNA, 5S ribosomal pseudogene 217 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:127664039-127664912 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:127665787-127666660 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SUMOylation of RNF146 results in Axin degradation and activation of Wnt/beta-catenin signaling to promote the progression of hepatocellular carcinoma.
    Title: SUMOylation of RNF146 results in Axin degradation and activation of Wnt/β-catenin signaling to promote the progression of hepatocellular carcinoma.
  2. Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.
    Title: Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.
  3. Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs.
    Title: Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs.
  4. Proteome-wide Analysis Reveals Substrates of E3 Ligase RNF146 Targeted for Degradation.
    Title: Proteome-wide Analysis Reveals Substrates of E3 Ligase RNF146 Targeted for Degradation.
  5. Rhododendrin is cytoprotective against 6-hydroxydopamine (6-OHDA)-induced cell death, which is largely dependent on ERbeta activity and RNF146 expression.
    Title: Rhododendrin-Induced RNF146 Expression via Estrogen Receptor β Activation is Cytoprotective Against 6-OHDA-Induced Oxidative Stress.
  6. RNF146 exerted oncogenic role through ubiquitination of Axin1 to activate beta-catenin signaling.
    Title: The E3 ubiquitin ligase RNF146 promotes colorectal cancer by activating the Wnt/β-catenin pathway via ubiquitination of Axin1.
  7. Iduna expression under disruptive neurohomeostasis (e.g., uncompensated oxidative stress or ischemic stroke after MCAo) is upregulated by neuroprotectin D1 and thus serves as a key regulator of cell survival, halting neural cell death.
    Title: Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke.
  8. the maintenance of unliganded RNF146 in an inactive state may serve to maintain the stability of the RNF146-TNKS complex, which in turn regulates the homeostasis of PARylation-dependent ubiquitination activity in the cell
    Title: Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.
  9. RNF146 regulated the development and progression of NSCLC
    Title: Overexpression of RNF146 in non-small cell lung cancer enhances proliferation and invasion of tumors through the Wnt/β-catenin signaling pathway.
  10. Iduna is a Poly(ADP-ribose)-dependent ubiquitin E3 ligase.
    Title: Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common variants at 6q22 and 17q21 are associated with intracranial volume.
EBI GWAS Catalog
Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • dJ351K20.1, 2610509H23Rik, DKFZp434O1427

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables poly-ADP-D-ribose binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly-ADP-D-ribose binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity TAS
Traceable Author Statement
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
  
involved_in protein K48-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF146
Names
RING-type E3 ubiquitin transferase RNF146
dactylidin
iduna
NP_001229773.1
NP_001229774.1
NP_001229775.1
NP_001229776.1
NP_001229777.1
NP_001229778.1
NP_001229779.1
NP_001229780.1
NP_001229781.1
NP_112225.2
XP_011534463.1
XP_011534465.1
XP_011534466.1
XP_016866825.1
XP_047275342.1
XP_047275343.1
XP_047275344.1
XP_047275345.1
XP_054212474.1
XP_054212475.1
XP_054212476.1
XP_054212477.1
XP_054212478.1
XP_054212479.1
XP_054212480.1
XP_054212481.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242844.2 → NP_001229773.1  E3 ubiquitin-protein ligase RNF146 isoform a

    See identical proteins and their annotated locations for NP_001229773.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (a). Variants 1-7 encode the same isoform (a).
    Source sequence(s)
    AJ420549, DA639989
    Consensus CDS
    CCDS5136.1
    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:103 → 175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:35 → 74
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

  2. NM_001242845.2 → NP_001229774.1  E3 ubiquitin-protein ligase RNF146 isoform a

    See identical proteins and their annotated locations for NP_001229774.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).
    Source sequence(s)
    AJ420549, BI669435, DA707096, DB267873
    Consensus CDS
    CCDS5136.1
    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:103 → 175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:35 → 74
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

  3. NM_001242846.2 → NP_001229775.1  E3 ubiquitin-protein ligase RNF146 isoform a

    See identical proteins and their annotated locations for NP_001229775.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).
    Source sequence(s)
    AJ420549, DA043259, DB267873
    Consensus CDS
    CCDS5136.1
    UniProtKB/Swiss-Prot
    Q9NTX7
    Related
    ENSP00000477168.1, ENST00000608991.5
    Conserved Domains (2) summary
    smart00678
    Location:103 → 175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:35 → 74
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

  4. NM_001242847.2 → NP_001229776.1  E3 ubiquitin-protein ligase RNF146 isoform a

    See identical proteins and their annotated locations for NP_001229776.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).
    Source sequence(s)
    AJ420549, DA707096
    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:103 → 175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:35 → 74
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

  5. NM_001242848.2 → NP_001229777.1  E3 ubiquitin-protein ligase RNF146 isoform a

    See identical proteins and their annotated locations for NP_001229777.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).
    Source sequence(s)
    AJ420549, DA145911
    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:103 → 175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:35 → 74
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

  6. NM_001242849.2 → NP_001229778.1  E3 ubiquitin-protein ligase RNF146 isoform b

    See identical proteins and their annotated locations for NP_001229778.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks two alternate internal exons, which results in the use of an upstream start codon, compared to variant 1. The encoded isoform (b) has a longer N-terminus than isoform a. Variants 8-10 encode the same isoform (b).
    Source sequence(s)
    AI929027, AJ420549, CN388414
    Consensus CDS
    CCDS56449.1
    UniProtKB/Swiss-Prot
    E1P572, Q6FIB2, Q7L8H4, Q96K03, Q96T06, Q9NTX6, Q9NTX7
    Related
    ENSP00000476814.1, ENST00000610153.1
    Conserved Domains (2) summary
    smart00678
    Location:104 → 176
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:36 → 75
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

  7. NM_001242850.2 → NP_001229779.1  E3 ubiquitin-protein ligase RNF146 isoform b

    See identical proteins and their annotated locations for NP_001229779.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks two alternate internal exons, which results in the use of an upstream start codon, compared to variant 1. The encoded isoform (b) has a longer N-terminus than isoform a. Variants 8-10 encode the same isoform (b).
    Source sequence(s)
    AJ420549, AK027558
    Consensus CDS
    CCDS56449.1
    UniProtKB/Swiss-Prot
    E1P572, Q6FIB2, Q7L8H4, Q96K03, Q96T06, Q9NTX6, Q9NTX7
    Related
    ENSP00000357297.1, ENST00000368314.6
    Conserved Domains (2) summary
    smart00678
    Location:104 → 176
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:36 → 75
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

  8. NM_001242851.1 → NP_001229780.1  E3 ubiquitin-protein ligase RNF146 isoform b

    See identical proteins and their annotated locations for NP_001229780.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) contains an alternate 5' terminal exon and lacks two alternate internal exons, which results in the use of an upstream start codon, compared to variant 1. The encoded isoform (b) has a longer N-terminus than isoform a. Variants 8-10 encode the same isoform (b).
    Source sequence(s)
    AJ420549, BG708628, BI771613
    Consensus CDS
    CCDS56449.1
    UniProtKB/Swiss-Prot
    E1P572, Q6FIB2, Q7L8H4, Q96K03, Q96T06, Q9NTX6, Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:104 → 176
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:36 → 75
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

  9. NM_001242852.2 → NP_001229781.1  E3 ubiquitin-protein ligase RNF146 isoform a

    See identical proteins and their annotated locations for NP_001229781.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1-4 and variant 7 encode the same isoform.
    Source sequence(s)
    AI929027, AJ420549, AL136829, DA826982
    Consensus CDS
    CCDS5136.1
    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:103 → 175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:35 → 74
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

  10. NM_030963.4 → NP_112225.2  E3 ubiquitin-protein ligase RNF146 isoform a

    See identical proteins and their annotated locations for NP_112225.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).
    Source sequence(s)
    AJ420549, AL136829, DB267873
    Consensus CDS
    CCDS5136.1
    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:103 → 175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:35 → 74
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    127266682..127288562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011336.3 → XP_016866825.1  E3 ubiquitin-protein ligase RNF146 isoform X1

    UniProtKB/Swiss-Prot
    E1P572, Q6FIB2, Q7L8H4, Q96K03, Q96T06, Q9NTX6, Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:104 → 176
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:36 → 75
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

  2. XM_047419389.1 → XP_047275345.1  E3 ubiquitin-protein ligase RNF146 isoform X2

  3. XM_047419386.1 → XP_047275342.1  E3 ubiquitin-protein ligase RNF146 isoform X2

  4. XM_047419388.1 → XP_047275344.1  E3 ubiquitin-protein ligase RNF146 isoform X2

  5. XM_011536161.4 → XP_011534463.1  E3 ubiquitin-protein ligase RNF146 isoform X2

    See identical proteins and their annotated locations for XP_011534463.1

    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:103 → 175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:35 → 74
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

  6. XM_011536163.4 → XP_011534465.1  E3 ubiquitin-protein ligase RNF146 isoform X2

    See identical proteins and their annotated locations for XP_011534465.1

    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:103 → 175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:35 → 74
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

  7. XM_011536164.4 → XP_011534466.1  E3 ubiquitin-protein ligase RNF146 isoform X2

    See identical proteins and their annotated locations for XP_011534466.1

    UniProtKB/Swiss-Prot
    Q9NTX7
    Conserved Domains (2) summary
    smart00678
    Location:103 → 175
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16546
    Location:35 → 74
    RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

  8. XM_047419387.1 → XP_047275343.1  E3 ubiquitin-protein ligase RNF146 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    128455637..128477520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356499.1 → XP_054212474.1  E3 ubiquitin-protein ligase RNF146 isoform X1

    UniProtKB/Swiss-Prot
    E1P572, Q6FIB2, Q7L8H4, Q96K03, Q96T06, Q9NTX6, Q9NTX7

  2. XM_054356503.1 → XP_054212478.1  E3 ubiquitin-protein ligase RNF146 isoform X2

  3. XM_054356500.1 → XP_054212475.1  E3 ubiquitin-protein ligase RNF146 isoform X2

  4. XM_054356502.1 → XP_054212477.1  E3 ubiquitin-protein ligase RNF146 isoform X2

  5. XM_054356504.1 → XP_054212479.1  E3 ubiquitin-protein ligase RNF146 isoform X2

  6. XM_054356505.1 → XP_054212480.1  E3 ubiquitin-protein ligase RNF146 isoform X2

  7. XM_054356506.1 → XP_054212481.1  E3 ubiquitin-protein ligase RNF146 isoform X2

  8. XM_054356501.1 → XP_054212476.1  E3 ubiquitin-protein ligase RNF146 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NTX7.1 GenPept UniProtKB/Swiss-Prot:Q9NTX7

Gene LinkOut

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