Gnrhr gonadotropin releasing hormone receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gnrhrprovided by RGD
Official Full Name: gonadotropin releasing hormone receptorprovided by RGD
Primary source: RGD:70513
See related: AllianceGenome:RGD:70513
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GH1; Lhrhr
Summary: Enables growth hormone-releasing hormone receptor activity. Involved in G protein-coupled receptor signaling pathway; circadian rhythm; and negative regulation of cell population proliferation. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 7 with or without anosmia. Orthologous to human GNRHR (gonadotropin releasing hormone receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 82.5), Adrenal (RPKM 42.5) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 14p21

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (22211666..22229654)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (21856871..21874861)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (23480462..23498450)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gonadotrophin-releasing hormone receptor autoantibodies induce polycystic ovary syndrome-like features in a rat model.
Title: Gonadotrophin-releasing hormone receptor autoantibodies induce polycystic ovary syndrome-like features in a rat model.
the age-dependent basal and regulated Gnrhr transcription could account for the initial blockade and subsequent activation of the reproductive system during development.
Title: The relationship between basal and regulated Gnrhr expression in rodent pituitary gonadotrophs.
Prevention of estradiol synthesis blocked the ability of peripheral estradiol administration in ovariectomized rats to enhance hippocampus-dependent memory in a radial-maze task. Hippocampal GnRH receptor antagonism blocked the ability of peripheral estradiol administration in ovariectomized rats to enhance hippocampus-dependent memory.
Title: Circulating Estradiol Regulates Brain-Derived Estradiol via Actions at GnRH Receptors to Impact Memory in Ovariectomized Rats.
GnRH-R is expressed in the mammary tissues after weaning; GnRH is involved in the involution and tissue remodeling of post-lactating rat mammary tissues
Title: Augmentation of gonadotropin-releasing hormone receptor expression in the post-lactational mammary tissues of rats.
Gnrhr promoter sequences are mainly responsible for directing transcriptional programmes and play a predominant role over the species-specific cell environment.
Title: Inside and outside the pituitary: comparative analysis of Gnrhr expression provides insight into the mechanisms underlying the evolution of gene expression.
Downregulation of Gnrh may be involved in the development of sex hormone disorder and calcium loss.
Title: Exogenous leptin administered intramuscularly induces sex hormone disorder and Ca loss via downregulation of Gnrh and PI3K expression.
Data indicate that GnRH-R expression is strongest in the hippocampus of adult female rats.
Title: Endocrine regulation of estrogen synthesis in the hippocampus?
Rather than using alternate promoters, Gnrhr expression is directed to diverse cell lineages through specific associations of transcription factors acting on distinct response elements along the same promoter.
Title: Identification and analysis of two novel sites of rat GnRH receptor gene promoter activity: the pineal gland and retina.
The trans-repressive action of GATA2 on Gnrhr promoter activity is likely balanced or even hindered by trans-activating effects of LIM homeodomain proteins.
Title: GATA2-induced silencing and LIM-homeodomain protein-induced activation are mediated by a bi-functional response element in the rat GnRH receptor gene.
SET protein interacts with intracellular domains of the gonadotropin-releasing hormone receptor and differentially regulates receptor signaling to cAMP and calcium in gonadotrope cells
Title: SET protein interacts with intracellular domains of the gonadotropin-releasing hormone receptor and differentially regulates receptor signaling to cAMP and calcium in gonadotrope cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables gonadotropin-releasing hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables gonadotropin-releasing hormone receptor activity	IEA Inferred from Electronic Annotation more info
enables gonadotropin-releasing hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables growth hormone-releasing hormone receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to gonadotropin-releasing hormone	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: gonadotropin-releasing hormone receptor

Names: gnRH receptor; gnRH-R; growth hormone

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031038.3 → NP_112300.2 gonadotropin-releasing hormone receptor

See identical proteins and their annotated locations for NP_112300.2

Status: VALIDATED

Source sequence(s)

CB775870, JAXUCZ010000014, L07646, X68980

UniProtKB/Swiss-Prot

P30969

UniProtKB/TrEMBL

A6JCR6, G3V693

Conserved Domains (2) summary

cd14964
Location:37 → 68

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:36 → 327

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily