Ceacam1 CEA cell adhesion molecule 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ceacam1provided by RGD
Official Full Name: CEA cell adhesion molecule 1provided by RGD
Primary source: RGD:67396
See related: EnsemblRapid:ENSRNOG00000020578 AllianceGenome:RGD:67396
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bgp; BGPR; CD66a; Ccam1
Summary: Enables several functions, including bile acid transmembrane transporter activity; calmodulin binding activity; and protein homodimerization activity. Involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; insulin catabolic process; and regulation of signal transduction. Acts upstream of or within positive regulation of MAP kinase activity. Located in several cellular components, including adherens junction; basal plasma membrane; and lateral plasma membrane. Orthologous to several human genes including CEACAM1 (CEA cell adhesion molecule 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 224.1), Lung (RPKM 110.0) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1q21

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (90171401..90187810, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (81043595..81060050, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (82327955..82344345, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses
Title: Soluble CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses.
the transmembrane domain is an important determinant of CEACAM1-4S functionality
Title: The transmembrane domain of CEACAM1-4S is a determinant of anchorage independent growth and tumorigenicity.
Insulin acutely reduces hepatic FAS activity by inducing phosphorylation of the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and its interaction with FAS.
Title: Insulin acutely decreases hepatic fatty acid synthase activity.
ovariectomy decreases the mineralization process and the osteocalcin expression during the chronology of the alveolar healing process that is not totally recovered with estrogen replacement or raloxifene treatment.
Title: Osteocalcin immunolabeling during the alveolar healing process in ovariectomized rats treated with estrogen or raloxifene.
Transmembrane signaling by CEACAM1 operates by alteration of the monomer/dimer equilibrium, which leads to changes in the SHP-2 phosphatase/c-Src kinase-binding ratio.
Title: Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src.
A mechanism involving adhesion-influenced dynamic changes of CEACAM1 microcluster organization exists in epithelial cells.
Title: The CEACAM1 N-terminal Ig domain mediates cis- and trans-binding and is essential for allosteric rearrangements of CEACAM1 microclusters.
CEACAM1 is a direct target of SOX9 in the colon epithelium
Title: CEACAM1, a SOX9 direct transcriptional target identified in the colon epithelium.
PDIP38 can shuttle between the cytoplasmic and the nuclear compartments and that its subcellular localization is regulated by CEACAM1
Title: The cell adhesion receptor carcinoembryonic antigen-related cell adhesion molecule 1 regulates nucleocytoplasmic trafficking of DNA polymerase delta-interacting protein 38.
Two novel splice variants, designated CEACAM1-4C1 and CEACAM1-4C2, lacking the transmembrane region, were identified in this study.
Title: Secreted CEACAM1 splice variants in rat cell lines and in vivo in rat serum.
CEACAM1 influences the resolution of inflammation by prolonging the survival of rat granulocytes.
Title: CEACAM1 (CD66a) mediates delay of spontaneous and Fas ligand-induced apoptosis in granulocytes.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Markers

BI274452 (e-PCR)
- UniSTS:249090

BE097239 (e-PCR)
- UniSTS:244625

RH142426 (e-PCR)
- UniSTS:231673

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Toll-like receptor binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables bile acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables filamin binding	ISO Inferred from Sequence Orthology more info
enables granulocyte colony-stimulating factor receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IDA Inferred from Direct Assay more info	PubMed
involved_in blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in blood vessel development	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell junction organization	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in common myeloid progenitor cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in common myeloid progenitor cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in granulocyte colony-stimulating factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in granulocyte colony-stimulating factor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin catabolic process	ISO Inferred from Sequence Orthology more info
involved_in insulin catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in insulin receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of bone resorption	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytotoxic T cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytotoxic T cell degranulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of granulocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of granulocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of hepatocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hepatocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hepatocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-1 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of platelet aggregation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of platelet aggregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular permeability	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of homophilic cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasculogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of blood vessel remodeling	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood vessel remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of endothelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of endothelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of epidermal growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of homophilic cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of immune system process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in wound healing, spreading of cells	ISO Inferred from Sequence Orthology more info
involved_in wound healing, spreading of cells	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of T cell receptor complex	ISO Inferred from Sequence Orthology more info
part_of T cell receptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in ciliary membrane	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in microvillus membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in transport vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: carcinoembryonic antigen-related cell adhesion molecule 1

Names: ATP-dependent taurocolate-carrier protein; C-CAM 105; CEA-related cell adhesion molecule 1 (bone gamma-carboxyglutamic acid (Gla) protein) (osteocalcin); GP110; bone gamma-carboxyglutamic acid (Gla) protein; carcinoembryonic antigen related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); cell-CAM 105; ecto-ATPase; osteocalcin; pp120; pp120/ecto-ATPase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033860.1 → NP_001029032.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_001029032.1

Status: VALIDATED

Source sequence(s)

BC061740, J04963, JAXUCZ010000001, M92848

UniProtKB/Swiss-Prot

P16573, Q63093

UniProtKB/TrEMBL

A0A8I6A3J5, A6J963

Related

ENSRNOP00000046654.3, ENSRNOT00000051892.8

Conserved Domains (4) summary

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00410
Location:331 → 410

IG_like; Immunoglobulin like

pfam13895
Location:240 → 318

Ig_2; Immunoglobulin domain

cl11960
Location:146 → 233

Ig; Immunoglobulin domain
NM_001033861.1 → NP_001029033.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_001029033.1

Status: VALIDATED

Source sequence(s)

AJ277105, BC061740, J04963, JAXUCZ010000001, M92848

UniProtKB/TrEMBL

A0A8I6A3J5, F7EVH5, Q9JHL6

Related

ENSRNOP00000027933.4, ENSRNOT00000027933.8

Conserved Domains (4) summary

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00410
Location:331 → 410

IG_like; Immunoglobulin like

pfam13895
Location:240 → 318

Ig_2; Immunoglobulin domain

cl11960
Location:146 → 233

Ig; Immunoglobulin domain
NM_001033862.1 → NP_001029034.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 3 precursor

See identical proteins and their annotated locations for NP_001029034.1

Status: VALIDATED

Source sequence(s)

BC061740, J04963, JAXUCZ010000001, M92848, X91137

UniProtKB/TrEMBL

A6J966

Related

ENSRNOP00000074820.1, ENSRNOT00000090629.3

Conserved Domains (4) summary

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00410
Location:331 → 410

IG_like; Immunoglobulin like

pfam13895
Location:240 → 318

Ig_2; Immunoglobulin domain

cl11960
Location:146 → 233

Ig; Immunoglobulin domain
NM_031755.2 → NP_113943.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 4 precursor

See identical proteins and their annotated locations for NP_113943.1

Status: VALIDATED

Source sequence(s)

AJ277104, BC061740, J04963, JAXUCZ010000001, M92848

UniProtKB/TrEMBL

F7EUP5, F7F6B2, Q9JHL7

Related

ENSRNOP00000031260.4, ENSRNOT00000029487.9

Conserved Domains (4) summary

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00410
Location:331 → 410

IG_like; Immunoglobulin like

pfam13895
Location:240 → 318

Ig_2; Immunoglobulin domain

cl11960
Location:146 → 233

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

90171401..90187810 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091997.2 → XP_038947925.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform X2

Conserved Domains (2) summary

cd05740
Location:7 → 95

IgI_hCEACAM_2_4_6_like; Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains

cd20948
Location:104 → 179

IgC2_CEACAM5-like; Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains; member of the C2-set IgSF domains
XM_063275061.1 → XP_063131131.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform X1

Related

ENSRNOP00000085270.1, ENSRNOT00000103781.2
XM_039092002.2 → XP_038947930.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform X3

UniProtKB/TrEMBL

Q78E86

Conserved Domains (1) summary

cd05774
Location:36 → 140

IgV_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)