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ADAM33 ADAM metallopeptidase domain 33 [ Homo sapiens (human) ]

Gene ID: 80332, updated on 2-Nov-2024

Summary

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Official Symbol
ADAM33provided by HGNC
Official Full Name
ADAM metallopeptidase domain 33provided by HGNC
Primary source
HGNC:HGNC:15478
See related
Ensembl:ENSG00000149451 MIM:607114; AllianceGenome:HGNC:15478
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C20orf153; DJ964F7.1
Summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
Expression
Broad expression in endometrium (RPKM 33.9), gall bladder (RPKM 16.7) and 17 other tissues See more
Orthologs
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Genomic context

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See ADAM33 in Genome Data Viewer
Location:
20p13
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (3667975..3682010, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (3698909..3712954, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3648622..3662657, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene attractin Neighboring gene splicing factor 3a, subunit 3 pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:3601641-3601840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12622 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12623 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr20:3647557-3648086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3651223-3651828 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3657784-3658386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3658990-3659591 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3662082-3662975 Neighboring gene GDNF family receptor alpha 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3678505-3679004 Neighboring gene Sharpr-MPRA regulatory region 3812 Neighboring gene sialic acid binding Ig like lectin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12624 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_60092 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3713394-3713973 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3722898-3723425 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3725082-3725992 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3729440-3729992 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3729993-3730543 Neighboring gene heat shock protein family A (Hsp70) member 12B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Evaluation of the association between clinical parameters and ADAM33 and ORMDL3 asthma gene single-nucleotide polymorphisms with the severity of COVID-19.
    Title: Evaluation of the association between clinical parameters and ADAM33 and ORMDL3 asthma gene single-nucleotide polymorphisms with the severity of COVID-19.
  2. The rs16969968 Tobacco Smoking-Related Single-Nucleotide Variant Is Associated with Clinical Markers in Patients with Severe COVID-19.
    Title: The rs16969968 Tobacco Smoking-Related Single-Nucleotide Variant Is Associated with Clinical Markers in Patients with Severe COVID-19.
  3. Role of ADAM33 short isoform as a tumor suppressor in the pathogenesis of thyroid cancer via oncogenic function disruption of full-length ADAM33.
    Title: Role of ADAM33 short isoform as a tumor suppressor in the pathogenesis of thyroid cancer via oncogenic function disruption of full-length ADAM33.
  4. The strong correlation between ADAM33 expression and airway inflammation in chronic obstructive pulmonary disease and candidate for biomarker and treatment of COPD.
    Title: The strong correlation between ADAM33 expression and airway inflammation in chronic obstructive pulmonary disease and candidate for biomarker and treatment of COPD.
  5. Signatures for chronic obstructive pulmonary disease (COPD) and asthma: a comparative genetic analysis.
    Title: Signatures for chronic obstructive pulmonary disease (COPD) and asthma: a comparative genetic analysis.
  6. Silencing a disintegrin and metalloproteinase33 attenuates the proliferation of vascular smooth muscle cells via PI3K/AKT pathway: Implications in the pathogenesis of airway vascular remodeling.
    Title: Silencing a disintegrin and metalloproteinase‑33 attenuates the proliferation of vascular smooth muscle cells via PI3K/AKT pathway: Implications in the pathogenesis of airway vascular remodeling.
  7. ADAM33 rs2280090 and rs2280091 may be associated with asthma in a pilot case-control study
    Title: Haplotype analysis of ADAM33 polymorphisms in asthma: A pilot study.
  8. The rs2280089, rs2280090, and rs2280091 SNPs of ADAM33 appeared to be non-significant for asthma susceptibility in Northern and Central Punjabi population.
    Title: Evaluation of ADAM33 gene's single nucleotide polymorphism variants against asthma and the unique pattern of inheritance in Northern and Central Punjab, Pakistan.
  9. In a case-control study ADAM33 rs678881 polymorphism significantly increased the risk of childhood asthma in Chinese Han population, but not rs2280089 or rs2853209.
    Title: Genetic association of ADAM33 polymorphisms with childhood asthma in Chinese Han population: A case-control study.
  10. ADAM33 F+1 mutant gene A may increase the risk of chronic obstructive pulmonary disease among the Asian population, while it may not associate with the European population
    Title: Association between F+1 polymorphism in a disintegrin and metalloprotease 33 (ADAM33) gene and chronic obstructive pulmonary disease susceptibility: An evidence-based meta-analysis.
Submit: New GeneRIF Correction See all GeneRIFs (123)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ35308, FLJ36751, MGC71889, MGC149823, DKFZp434K0521

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 33
Names
ADAM 33
a disintegrin and metalloprotease 33
a disintegrin and metalloproteinase domain 33
disintegrin and reprolysin metalloproteinase family protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282447.3 → NP_001269376.1  disintegrin and metalloproteinase domain-containing protein 33 isoform gamma precursor

    See identical proteins and their annotated locations for NP_001269376.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform gamma), compared to isoform alpha. The encoded isoform (gamma) may undergo proteolytic processing similar to isoform alpha.
    Source sequence(s)
    AF466287, AK126487, AL356755
    Consensus CDS
    CCDS63219.1
    UniProtKB/TrEMBL
    A2A2L3, Q08AM2
    Related
    ENSP00000369190.4, ENST00000379861.8
    Conserved Domains (5) summary
    smart00050
    Location:426 → 500
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:502 → 644
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:210 → 407
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:210 → 409
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:83 → 164
    Pep_M12B_propep; Reprolysin family propeptide

  2. NM_025220.5 → NP_079496.1  disintegrin and metalloproteinase domain-containing protein 33 isoform alpha preproprotein

    See identical proteins and their annotated locations for NP_079496.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (alpha).
    Source sequence(s)
    AL356755, AY358314
    Consensus CDS
    CCDS13058.1
    UniProtKB/Swiss-Prot
    A0A1K6, Q5JT75, Q5JT76, Q8N0W6, Q9BZ11
    UniProtKB/TrEMBL
    Q08AM2
    Related
    ENSP00000348912.3, ENST00000356518.7
    Conserved Domains (5) summary
    smart00050
    Location:426 → 500
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:502 → 644
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:210 → 407
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:210 → 409
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:83 → 164
    Pep_M12B_propep; Reprolysin family propeptide

  3. NM_153202.4 → NP_694882.1  disintegrin and metalloproteinase domain-containing protein 33 isoform beta precursor

    See identical proteins and their annotated locations for NP_694882.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, as compared to variant 1. It encodes isoform beta, which lacks an internal segment, but has the same N- and C-termini as isoform alpha. The encoded isoform (beta) may undergo proteolytic processing similar to isoform alpha.
    Source sequence(s)
    AK126487, AL356755, DB225158
    UniProtKB/TrEMBL
    Q08AM2
    Related
    ENSP00000322550.5, ENST00000350009.6
    Conserved Domains (5) summary
    smart00050
    Location:426 → 500
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:502 → 643
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:210 → 407
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:210 → 409
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:83 → 164
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    3667975..3682010 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529367.2 → XP_011527669.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X5

    UniProtKB/TrEMBL
    Q08AM2
    Conserved Domains (5) summary
    smart00050
    Location:425 → 499
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:501 → 643
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:209 → 406
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:209 → 408
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:88 → 163
    Pep_M12B_propep; Reprolysin family propeptide

  2. XM_011529366.2 → XP_011527668.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X3

    UniProtKB/TrEMBL
    Q08AM2
    Conserved Domains (5) summary
    smart00050
    Location:438 → 512
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:514 → 656
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:222 → 419
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:222 → 421
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:88 → 176
    Pep_M12B_propep; Reprolysin family propeptide

  3. XM_006723640.2 → XP_006723703.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X4

    UniProtKB/TrEMBL
    Q08AM2
    Conserved Domains (5) summary
    smart00050
    Location:436 → 510
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:512 → 654
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:223 → 417
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:223 → 419
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:83 → 177
    Pep_M12B_propep; Reprolysin family propeptide

  4. XM_047440516.1 → XP_047296472.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X7

  5. XM_047440515.1 → XP_047296471.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X6

  6. XM_047440514.1 → XP_047296470.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X2

  7. XM_005260843.2 → XP_005260900.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X1

    UniProtKB/TrEMBL
    Q08AM2
    Conserved Domains (5) summary
    smart00050
    Location:439 → 513
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:515 → 657
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:223 → 420
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:223 → 422
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:83 → 177
    Pep_M12B_propep; Reprolysin family propeptide

  8. XM_011529370.2 → XP_011527672.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X8

    See identical proteins and their annotated locations for XP_011527672.1

    Conserved Domains (5) summary
    smart00050
    Location:439 → 513
    DISIN; Homologues of snake disintegrins
    cd04269
    Location:223 → 420
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:223 → 422
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:83 → 177
    Pep_M12B_propep; Reprolysin family propeptide
    cl15456
    Location:515 → 548
    ADAM_CR; ADAM cysteine-rich

  9. XM_047440517.1 → XP_047296473.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X8

  10. XM_017028081.3 → XP_016883570.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X11

  11. XM_011529371.3 → XP_011527673.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X9

    Conserved Domains (2) summary
    cd04269
    Location:223 → 343
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01562
    Location:83 → 177
    Pep_M12B_propep; Reprolysin family propeptide

  12. XM_017028080.3 → XP_016883569.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X10

  13. XM_006723644.3 → XP_006723707.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X12

    Conserved Domains (4) summary
    smart00050
    Location:439 → 479
    DISIN; Homologues of snake disintegrins
    cd04269
    Location:223 → 420
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:223 → 422
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:83 → 177
    Pep_M12B_propep; Reprolysin family propeptide

  14. XM_017028083.2 → XP_016883572.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X14

    UniProtKB/TrEMBL
    B4E1Y6

  15. XM_017028082.2 → XP_016883571.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X13

RNA

  1. XR_937152.2 RNA Sequence

  2. XR_937151.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    3698909..3712954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324050.1 → XP_054180025.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X5

  2. XM_054324048.1 → XP_054180023.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X3

  3. XM_054324049.1 → XP_054180024.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X4

  4. XM_054324052.1 → XP_054180027.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X7

  5. XM_054324051.1 → XP_054180026.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X6

  6. XM_054324047.1 → XP_054180022.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X2

  7. XM_054324046.1 → XP_054180021.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X1

  8. XM_054324054.1 → XP_054180029.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X8

  9. XM_054324053.1 → XP_054180028.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X8

  10. XM_054324057.1 → XP_054180032.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X11

  11. XM_054324055.1 → XP_054180030.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X9

  12. XM_054324056.1 → XP_054180031.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X10

  13. XM_054324058.1 → XP_054180033.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X12

  14. XM_054324060.1 → XP_054180035.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X14

  15. XM_054324059.1 → XP_054180034.1  disintegrin and metalloproteinase domain-containing protein 33 isoform X13

RNA

  1. XR_008485300.1 RNA Sequence

  2. XR_008485299.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BZ11.2 GenPept UniProtKB/Swiss-Prot:Q9BZ11

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