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Tusc3 tumor suppressor candidate 3 [ Mus musculus (house mouse) ]

Gene ID: 80286, updated on 2-Nov-2024

Summary

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Official Symbol
Tusc3provided by MGI
Official Full Name
tumor suppressor candidate 3provided by MGI
Primary source
MGI:MGI:1933134
See related
Ensembl:ENSMUSG00000118664 AllianceGenome:MGI:1933134
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
N33
Summary
Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in cognition; magnesium ion transport; and protein N-linked glycosylation via asparagine. Located in mitochondrion. Is expressed in nervous system; neural retina; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 7. Orthologous to human TUSC3 (tumor suppressor candidate 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 43.6), whole brain E14.5 (RPKM 27.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Tusc3 in Genome Data Viewer
Location:
8 A4; 8 23.89 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (39472505..39620091)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (39005351..39167050)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene sarcoglycan zeta Neighboring gene STARR-seq mESC enhancer starr_21246 Neighboring gene STARR-seq mESC enhancer starr_21247 Neighboring gene predicted gene, 40493 Neighboring gene STARR-seq mESC enhancer starr_21248 Neighboring gene STARR-seq mESC enhancer starr_21249 Neighboring gene STARR-seq mESC enhancer starr_21250 Neighboring gene predicted gene, 23128 Neighboring gene STARR-seq mESC enhancer starr_21252 Neighboring gene STARR-seq mESC enhancer starr_21253 Neighboring gene STARR-positive B cell enhancer mm9_chr8:40240716-40241017 Neighboring gene MAD homolog 2 pseudogene Neighboring gene ribosomal protein L10A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties. Kelleher DJ, et al. Mol Cell, 2003 Jul. PMID 12887896
  2. A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cells. Roma G, et al. Genome Res, 2007 Jul. PMID 17540781, Free PMC Article
  3. Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice. Horiuchi K, et al. Cell Rep, 2018 Apr 3. PMID 29617656
  4. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC6989

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables magnesium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cognition ISO
Inferred from Sequence Orthology
more info
  
involved_in cognition ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in magnesium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in magnesium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in magnesium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein N-linked glycosylation via asparagine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation via asparagine ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
part_of oligosaccharyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of oligosaccharyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of oligosaccharyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tumor suppressor candidate 3
Names
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3
magnesium uptake/transporter TUSC3
oligosaccharyl transferase subunit TUSC3
putative prostate cancer tumor suppressor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357304.1 → NP_001344233.1  tumor suppressor candidate 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC168314, AC174643
    Conserved Domains (1) summary
    pfam04756
    Location:45 → 215
    OST3_OST6; OST3 / OST6 family, transporter family

  2. NM_001357305.1 → NP_001344234.1  tumor suppressor candidate 3 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC168314, AC174643
    UniProtKB/TrEMBL
    Q8BMU5
    Conserved Domains (1) summary
    pfam04756
    Location:54 → 312
    OST3_OST6; OST3 / OST6 family, transporter family

  3. NM_001357306.1 → NP_001344235.1  tumor suppressor candidate 3 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC168314, AC174643
    UniProtKB/TrEMBL
    A0A7N9VR83, Q8BMU5
    Related
    ENSMUSP00000159387.2, ENSMUST00000239509.1
    Conserved Domains (1) summary
    pfam04756
    Location:54 → 342
    OST3_OST6; OST3 / OST6 family, transporter family

  4. NM_030254.4 → NP_084530.3  tumor suppressor candidate 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_084530.3

    Status: VALIDATED

    Source sequence(s)
    AK081223, AK132766, BC069898, BP765707
    Consensus CDS
    CCDS85529.1
    UniProtKB/Swiss-Prot
    Q8BTV1
    UniProtKB/TrEMBL
    Q8BMU5
    Related
    ENSMUSP00000159386.2, ENSMUST00000239508.1
    Conserved Domains (1) summary
    pfam04756
    Location:54 → 342
    OST3_OST6; OST3 / OST6 family, transporter family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    39472505..39620091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313026.3 → XP_017168515.1  tumor suppressor candidate 3 isoform X2

    UniProtKB/TrEMBL
    Q8BMU5
    Conserved Domains (1) summary
    pfam04756
    Location:54 → 295
    OST3_OST6; OST3 / OST6 family, transporter family

  2. XM_017313027.3 → XP_017168516.1  tumor suppressor candidate 3 isoform X3

    UniProtKB/TrEMBL
    Q8BMU5
    Conserved Domains (1) summary
    pfam04756
    Location:54 → 295
    OST3_OST6; OST3 / OST6 family, transporter family

  3. XM_017313024.3 → XP_017168513.1  tumor suppressor candidate 3 isoform X1

    UniProtKB/TrEMBL
    Q8BMU5
    Conserved Domains (1) summary
    pfam04756
    Location:54 → 312
    OST3_OST6; OST3 / OST6 family, transporter family

  4. XM_036154388.1 → XP_036010281.1  tumor suppressor candidate 3 isoform X5

    UniProtKB/TrEMBL
    Q8BMU5
    Conserved Domains (1) summary
    pfam04756
    Location:1 → 286
    OST3_OST6; OST3 / OST6 family, transporter family

  5. XM_017313028.2 → XP_017168517.1  tumor suppressor candidate 3 isoform X4

    UniProtKB/TrEMBL
    Q8BMU5
    Conserved Domains (1) summary
    pfam04756
    Location:4 → 286
    OST3_OST6; OST3 / OST6 family, transporter family

  6. XM_036154387.1 → XP_036010280.1  tumor suppressor candidate 3 isoform X5

    UniProtKB/TrEMBL
    Q8BMU5
    Conserved Domains (1) summary
    pfam04756
    Location:1 → 286
    OST3_OST6; OST3 / OST6 family, transporter family

  7. XM_017313029.2 → XP_017168518.1  tumor suppressor candidate 3 isoform X4

    UniProtKB/TrEMBL
    Q8BMU5
    Conserved Domains (1) summary
    pfam04756
    Location:4 → 286
    OST3_OST6; OST3 / OST6 family, transporter family

RNA

  1. XR_004934902.1 RNA Sequence

  2. XR_004934901.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BTV1.1 GenPept UniProtKB/Swiss-Prot:Q8BTV1

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