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ZNF606 zinc finger protein 606 [ Homo sapiens (human) ]

Gene ID: 80095, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF606provided by HGNC
Official Full Name
zinc finger protein 606provided by HGNC
Primary source
HGNC:HGNC:25879
See related
Ensembl:ENSG00000166704 MIM:613905; AllianceGenome:HGNC:25879
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF328
Summary
This gene encodes a zinc finger protein containing a Kruppel-associated box (KRAB) domain at its N-terminus, followed by contiguous C2H2 zinc finger motifs. The encoded protein is a nuclear protein that can act as a transcriptional repressor of growth factor-mediated signaling pathways in a reporter gene assay. This protein has been shown to interact with the SRY-box 9 gene product, and suppresses its transcriptional activity by inhibiting its DNA binding activity. Reduced expression of this gene promotes chondrocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Expression
Ubiquitous expression in thyroid (RPKM 3.6), testis (RPKM 3.3) and 25 other tissues See more
Orthologs
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Genomic context

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See ZNF606 in Genome Data Viewer
Location:
19q13.43
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57977053..58003346, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61073997..61100289, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58488421..58514714, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr19:58466320-58466487 Neighboring gene ribosomal protein L19 pseudogene 19 Neighboring gene chromosome 19 open reading frame 18 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15175 Neighboring gene ZNF606 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15177 Neighboring gene vomeronasal 2 receptor 19, pseudogene Neighboring gene Sharpr-MPRA regulatory region 748 Neighboring gene zinc finger and SCAN domain containing 1 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 1 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Association of expression of ZNF606 gene from monocytes with the risk of coronary artery disease. Guo J, et al. Clin Biochem, 2018 Sep. PMID 30130524
  2. ZNF328, a novel human zinc-finger protein, suppresses transcriptional activities of SRE and AP-1. Ou Y, et al. Biochem Biophys Res Commun, 2005 Aug 5. PMID 15964554
  3. ZNF606 interacts with Sox9 to regulate chondrocyte differentiation. Zhou Z, et al. Biochem Biophys Res Commun, 2016 Oct 28. PMID 27634221
  4. DBC1, p300, HDAC3, and Siah1 coordinately regulate ELL stability and function for expression of its target genes. Basu S, et al. Proc Natl Acad Sci U S A, 2020 Mar 24. PMID 32152128, Free PMC Article
  5. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2001 Apr 27. PMID 11347906

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings suggest that it is novel and specific for the association of ZNF606 gene expression from monocytes with the risk of CAD, especially in patients with multiple coronary artery stenosis
    Title: Association of expression of ZNF606 gene from monocytes with the risk of coronary artery disease.
  2. ZNF606 prevents Sox9 binding to the enhancers of its target gene col2a1. Importantly, the interaction between ZNF606 and Sox9 was decreased during chondrocyte differentiation.
    Title: ZNF606 interacts with Sox9 to regulate chondrocyte differentiation.
  3. results suggest that ZNF328 protein may act as a transcriptional repressor in mitogen-activated protein kinase (MAPK) signaling pathway to mediate cellular functions
    Title: ZNF328, a novel human zinc-finger protein, suppresses transcriptional activities of SRE and AP-1.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ14260, KIAA1852

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 606
Names
zinc finger protein 328

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053170.1 RefSeqGene

    Range
    5527..31271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001348022.3 → NP_001334951.1  zinc finger protein 606 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AB058755, AI766866, AK024322, DA800130
    Consensus CDS
    CCDS12968.1
    UniProtKB/Swiss-Prot
    A8KAN2, Q8NE04, Q8WXB4, Q96JH5
    Related
    ENSP00000446972.2, ENST00000551380.7
    Conserved Domains (3) summary
    smart00349
    Location:62 → 122
    KRAB; krueppel associated box
    COG5048
    Location:383 → 774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:458 → 478
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001348023.3 → NP_001334952.1  zinc finger protein 606 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Both variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AB058755, AI766866, AK024322, AK294037, DA800130
    UniProtKB/Swiss-Prot
    Q8WXB4
    UniProtKB/TrEMBL
    B4DFC8, Q9H7U2
    Conserved Domains (3) summary
    COG5048
    Location:293 → 684
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:368 → 388
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:1 → 32
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  3. NM_001348024.3 → NP_001334953.1  zinc finger protein 606 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Both variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AB058755, AI766866, AK024322, AK294037
    UniProtKB/Swiss-Prot
    Q8WXB4
    UniProtKB/TrEMBL
    B4DFC8, Q9H7U2
    Conserved Domains (3) summary
    COG5048
    Location:293 → 684
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:368 → 388
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:1 → 32
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  4. NM_001348025.3 → NP_001334954.1  zinc finger protein 606 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AB058755, AI766866, AK024322, DA577538, DA800130
    UniProtKB/Swiss-Prot
    Q8WXB4
    UniProtKB/TrEMBL
    Q9H7U2
    Conserved Domains (2) summary
    COG5048
    Location:225 → 616
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:300 → 320
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_025027.4 → NP_079303.2  zinc finger protein 606 isoform 1

    See identical proteins and their annotated locations for NP_079303.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AB058755, AI766866, AK024322
    Consensus CDS
    CCDS12968.1
    UniProtKB/Swiss-Prot
    A8KAN2, Q8NE04, Q8WXB4, Q96JH5
    Related
    ENSP00000343617.4, ENST00000341164.9
    Conserved Domains (3) summary
    smart00349
    Location:62 → 122
    KRAB; krueppel associated box
    COG5048
    Location:383 → 774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:458 → 478
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    57977053..58003346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    61073997..61100289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WXB4.1 GenPept UniProtKB/Swiss-Prot:Q8WXB4

Gene LinkOut

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