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DOK3 docking protein 3 [ Homo sapiens (human) ]

Gene ID: 79930, updated on 2-Nov-2024

Summary

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Official Symbol
DOK3provided by HGNC
Official Full Name
docking protein 3provided by HGNC
Primary source
HGNC:HGNC:24583
See related
Ensembl:ENSG00000146094 MIM:611435; AllianceGenome:HGNC:24583
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DOKL
Summary
Predicted to be involved in Ras protein signal transduction; cell surface receptor protein tyrosine kinase signaling pathway; and positive regulation of MAPK cascade. Predicted to be located in ficolin-1-rich granule membrane and plasma membrane. Predicted to be active in cytoplasm. Implicated in colorectal adenocarcinoma. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in bone marrow (RPKM 31.4), spleen (RPKM 15.5) and 11 other tissues See more
Orthologs
mouse all
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Genomic context

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See DOK3 in Genome Data Viewer
Location:
5q35.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (177501904..177511100, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (178044890..178054082, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176928905..176938101, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16692 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176884168-176884868 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176894101-176894646 Neighboring gene drebrin 1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:176895193-176895738 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:176895739-176896284 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176897377-176897922 Neighboring gene hESC enhancers GRCh37_chr5:176899493-176899996 and GRCh37_chr5:176899997-176900498 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176904724-176905224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176911017-176911732 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176911733-176912448 Neighboring gene Sharpr-MPRA regulatory region 15492 Neighboring gene PDZ and LIM domain 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176918835-176919378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176919379-176919920 Neighboring gene Sharpr-MPRA regulatory region 583 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176923257-176923998 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16700 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176925479-176926218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23721 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23722 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23723 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23724 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176929555-176930508 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176930509-176931460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23725 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23726 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16701 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23727 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:176943204-176944028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23728 Neighboring gene DEAD-box helicase 41 Neighboring gene family with sequence similarity 193 member B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16702 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:176981263-176981766

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression and clinical significance of DOK3 in renal clear cell carcinoma. Wang YF, et al. J Int Med Res, 2023 May. PMID 37235715, Free PMC Article
  2. Porphyromonas gingivalis Activation of Tumor-Associated Macrophages via DOK3 Promotes Recurrence of Oral Squamous Cell Carcinoma. Li CX, et al. Med Sci Monit, 2022 Oct 10. PMID 36210538, Free PMC Article
  3. Elevated expression of DOK3 indicates high suppressive immune cell infiltration and unfavorable prognosis of gliomas. Liu X, et al. Int Immunopharmacol, 2020 Jun. PMID 32193105
  4. Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike protein. Loh JT, et al. Front Immunol, 2022. PMID 36172386, Free PMC Article
  5. DOK3 negatively regulates LPS responses and endotoxin tolerance. Peng Q, et al. PLoS One, 2012. PMID 22761938, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11.
    Title: DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11.
  2. Expression and clinical significance of DOK3 in renal clear cell carcinoma.
    Title: Expression and clinical significance of DOK3 in renal clear cell carcinoma.
  3. Porphyromonas gingivalis Activation of Tumor-Associated Macrophages via DOK3 Promotes Recurrence of Oral Squamous Cell Carcinoma.
    Title: Porphyromonas gingivalis Activation of Tumor-Associated Macrophages via DOK3 Promotes Recurrence of Oral Squamous Cell Carcinoma.
  4. Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike protein.
    Title: Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike protein.
  5. Elevated expression of DOK3 indicates high suppressive immune cell infiltration and unfavorable prognosis of gliomas.
    Title: Elevated expression of DOK3 indicates high suppressive immune cell infiltration and unfavorable prognosis of gliomas.
  6. Mutations in DOK3 gene is associated with prostate cancer
    Title: Searching for candidate genes in familial BRCAX mutation carriers with prostate cancer.
  7. DOK2 and DOK3 expression was significantly reduced in HTLV-1-infected T cells.
    Title: Expression of DOK1, 2, and 3 genes in HTLV-1-infected T cells.
  8. The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters
    Title: The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters.
  9. absence of DOK3 increases LPS signaling, contributing to LPS-induced tolerance. Thus, DOK3 plays a role in TLR signaling during both naive and endotoxin-induced tolerant conditions
    Title: DOK3 negatively regulates LPS responses and endotoxin tolerance.
  10. Identification of DOK genes as lung tumor suppressors.
    Title: Identification of DOK genes as lung tumor suppressors.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22570, FLJ39939

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in secretory granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
docking protein 3
Names
Dok-like protein
downstream of tyrosine kinase 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144875.2 → NP_001138347.1  docking protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001138347.1

    Status: VALIDATED

    Source sequence(s)
    AC145098, BC004564, DA931137
    Consensus CDS
    CCDS47350.1
    UniProtKB/Swiss-Prot
    Q7L591
    Related
    ENSP00000325174.6, ENST00000312943.10
    Conserved Domains (2) summary
    cd14676
    Location:9 → 123
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
    cl17171
    Location:157 → 215
    PH-like; Pleckstrin homology-like domain

  2. NM_001144876.2 → NP_001138348.1  docking protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC145098, AK097258, BC004564, DA931137
    Consensus CDS
    CCDS47349.1
    UniProtKB/TrEMBL
    A0A6M4C8X9
    Related
    ENSP00000366316.4, ENST00000377112.8
    Conserved Domains (1) summary
    cl17171
    Location:55 → 113
    PH-like; Pleckstrin homology-like domain

  3. NM_001308235.3 → NP_001295164.1  docking protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001295164.1

    Status: VALIDATED

    Source sequence(s)
    AC145098
    Consensus CDS
    CCDS78098.1
    UniProtKB/Swiss-Prot
    E9PAT0, H7BXS0, Q7L591, Q8N864, Q9BQB3, Q9H666
    UniProtKB/TrEMBL
    D6RAM3, D6RAV2
    Related
    ENSP00000421688.1, ENST00000501403.6
    Conserved Domains (3) summary
    cd01203
    Location:157 → 255
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:9 → 123
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
    pfam03154
    Location:259 → 375
    Atrophin-1; Atrophin-1 family

  4. NM_001308236.3 → NP_001295165.1  docking protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001295165.1

    Status: VALIDATED

    Source sequence(s)
    AC145098
    Consensus CDS
    CCDS78098.1
    UniProtKB/Swiss-Prot
    E9PAT0, H7BXS0, Q7L591, Q8N864, Q9BQB3, Q9H666
    UniProtKB/TrEMBL
    D6RAM3, D6RAV2
    Related
    ENSP00000424726.2, ENST00000510898.7
    Conserved Domains (3) summary
    cd01203
    Location:157 → 255
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:9 → 123
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
    pfam03154
    Location:259 → 375
    Atrophin-1; Atrophin-1 family

  5. NM_001375794.1 → NP_001362723.1  docking protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC145098
    Consensus CDS
    CCDS78098.1
    UniProtKB/Swiss-Prot
    E9PAT0, H7BXS0, Q7L591, Q8N864, Q9BQB3, Q9H666
    UniProtKB/TrEMBL
    D6RAM3, D6RAV2
    Conserved Domains (3) summary
    cd01203
    Location:157 → 255
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:9 → 123
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
    pfam03154
    Location:259 → 375
    Atrophin-1; Atrophin-1 family

  6. NM_001375795.1 → NP_001362724.1  docking protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC145098
    Consensus CDS
    CCDS78098.1
    UniProtKB/Swiss-Prot
    E9PAT0, H7BXS0, Q7L591, Q8N864, Q9BQB3, Q9H666
    UniProtKB/TrEMBL
    D6RAM3, D6RAV2
    Conserved Domains (3) summary
    cd01203
    Location:157 → 255
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:9 → 123
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
    pfam03154
    Location:259 → 375
    Atrophin-1; Atrophin-1 family

  7. NM_001375796.1 → NP_001362725.1  docking protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC145098
    Consensus CDS
    CCDS78098.1
    UniProtKB/Swiss-Prot
    E9PAT0, H7BXS0, Q7L591, Q8N864, Q9BQB3, Q9H666
    UniProtKB/TrEMBL
    D6RAM3, D6RAV2
    Conserved Domains (3) summary
    cd01203
    Location:157 → 255
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:9 → 123
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
    pfam03154
    Location:259 → 375
    Atrophin-1; Atrophin-1 family

  8. NM_001375797.2 → NP_001362726.1  docking protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC145098
    Consensus CDS
    CCDS78098.1
    UniProtKB/Swiss-Prot
    E9PAT0, H7BXS0, Q7L591, Q8N864, Q9BQB3, Q9H666
    UniProtKB/TrEMBL
    D6RAM3, D6RAV2
    Conserved Domains (3) summary
    cd01203
    Location:157 → 255
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:9 → 123
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
    pfam03154
    Location:259 → 375
    Atrophin-1; Atrophin-1 family

  9. NM_001375798.1 → NP_001362727.1  docking protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC145098
    Consensus CDS
    CCDS47350.1
    Conserved Domains (2) summary
    cd14676
    Location:9 → 123
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
    cl17171
    Location:157 → 215
    PH-like; Pleckstrin homology-like domain

  10. NM_001375799.2 → NP_001362728.1  docking protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC145098
    Consensus CDS
    CCDS47350.1
    Conserved Domains (2) summary
    cd14676
    Location:9 → 123
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
    cl17171
    Location:157 → 215
    PH-like; Pleckstrin homology-like domain

  11. NM_001384137.1 → NP_001371066.1  docking protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC145098
    Consensus CDS
    CCDS78098.1
    UniProtKB/Swiss-Prot
    E9PAT0, H7BXS0, Q7L591, Q8N864, Q9BQB3, Q9H666
    UniProtKB/TrEMBL
    D6RAM3, D6RAV2
    Conserved Domains (3) summary
    cd01203
    Location:157 → 255
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:9 → 123
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
    pfam03154
    Location:259 → 375
    Atrophin-1; Atrophin-1 family

  12. NM_001384138.1 → NP_001371067.1  docking protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC145098
    UniProtKB/Swiss-Prot
    E9PAT0, H7BXS0, Q7L591, Q8N864, Q9BQB3, Q9H666
    Conserved Domains (3) summary
    cd01203
    Location:156 → 254
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:9 → 122
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
    pfam03154
    Location:258 → 374
    Atrophin-1; Atrophin-1 family

  13. NM_001384139.1 → NP_001371068.1  docking protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC145098
    UniProtKB/Swiss-Prot
    E9PAT0, H7BXS0, Q7L591, Q8N864, Q9BQB3, Q9H666
    Conserved Domains (3) summary
    cd01203
    Location:156 → 254
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:9 → 122
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
    pfam03154
    Location:258 → 374
    Atrophin-1; Atrophin-1 family

  14. NM_024872.4 → NP_079148.3  docking protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC145098
    Consensus CDS
    CCDS78098.1
    UniProtKB/Swiss-Prot
    E9PAT0, H7BXS0, Q7L591, Q8N864, Q9BQB3, Q9H666
    UniProtKB/TrEMBL
    D6RAM3, D6RAV2
    Related
    ENSP00000349727.5, ENST00000357198.9
    Conserved Domains (3) summary
    cd01203
    Location:157 → 255
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:9 → 123
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
    pfam03154
    Location:259 → 375
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    177501904..177511100 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417774.1 → XP_047273730.1  docking protein 3 isoform X2

  2. XM_047417775.1 → XP_047273731.1  docking protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A6M4C8X9

  3. XM_047417771.1 → XP_047273727.1  docking protein 3 isoform X1

  4. XM_047417772.1 → XP_047273728.1  docking protein 3 isoform X2

  5. XM_047417773.1 → XP_047273729.1  docking protein 3 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    178044890..178054082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353547.1 → XP_054209522.1  docking protein 3 isoform X4

    UniProtKB/TrEMBL
    D6RAM3, D6RAV2

  2. XM_054353551.1 → XP_054209526.1  docking protein 3 isoform X2

  3. XM_054353552.1 → XP_054209527.1  docking protein 3 isoform X3

  4. XM_054353548.1 → XP_054209523.1  docking protein 3 isoform X1

  5. XM_054353549.1 → XP_054209524.1  docking protein 3 isoform X2

  6. XM_054353550.1 → XP_054209525.1  docking protein 3 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7L591.2 GenPept UniProtKB/Swiss-Prot:Q7L591

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