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Gk glycerol kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 79223, updated on 2-Nov-2024

Summary

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Official Symbol
Gkprovided by RGD
Official Full Name
glycerol kinaseprovided by RGD
Primary source
RGD:70893
See related
EnsemblRapid:ENSRNOG00000034116 AllianceGenome:RGD:70893
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gyk; ASTP
Summary
Enables histone binding activity. Involved in response to ethanol; response to norepinephrine; and response to xenobiotic stimulus. Predicted to be located in cytosol and nucleus. Predicted to be active in mitochondrion. Used to study familial hypercholesterolemia. Human ortholog(s) of this gene implicated in glycerol kinase deficiency. Orthologous to several human genes including GK (glycerol kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 1065.8), Kidney (RPKM 718.8) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
Xq21
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (54106708..54189940, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (50162089..50238707, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (54227291..54303897, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene xanthine dehydrogenase, pseudogene 1 Neighboring gene TGF-beta activated kinase 1 (MAP3K7) binding protein 3 Neighboring gene replication protein A 14 kDa subunit pseudogene Neighboring gene uncharacterized LOC134484150

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Glycerol kinase and dihydroxyacetone kinase in rat brain. Jenkins BT, et al. J Neurochem, 1976 Feb. PMID 3631
  2. Properties of an adenosine triphosphate-stimulated factor that enhances the nuclear binding of activated glucocorticoid-receptor complex: binding to histone-agarose. Okamoto K, et al. Endocrinology, 1989 Feb. PMID 2912694
  3. Human and rat adrenal glycerol kinase: subcellular distribution and bisubstrate kinetics. Seltzer WK, et al. Mol Cell Biochem, 1984 Apr. PMID 6330523
  4. Molecular cloning of rat liver glucocorticoid-receptor translocation promoter. Okamoto K, et al. Biochem Biophys Res Commun, 1993 Jun 30. PMID 8323560
  5. Moonlighting function of glycerol kinase causes systems-level changes in rat hepatoma cells. Sriram G, et al. Metab Eng, 2010 Jul. PMID 20399282, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. To further elucidate the contributions of the enzymatic (phosphorylation) and alternative (ASTP) functions of GK in adipogenesis, we performed experiments on mammalian GK and E. coli GK. We determined that the ASTP function of GK (which is absent in E. coli GK) plays a greater role than the enzymatic activity in these processes.
    Title: The ATP-stimulated translocation promoter (ASTP) activity of glycerol kinase plays central role in adipogenesis.
  2. This systems biology approach further emphasizes glucose kinase's essential role in central and lipid metabolism and experimentally verifies lucose kinase's alternative function of affecting glucocorticoid receptor transcription factor activity.
    Title: Moonlighting function of glycerol kinase causes systems-level changes in rat hepatoma cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables glycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerol kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycerol kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycerol kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in glycerol catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glycerol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycerol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycerol-3-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerol-3-phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycerol-3-phosphate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycerol-3-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to ethanol IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to norepinephrine IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in triglyceride metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
glycerol kinase
Names
ATP-stimulated glucocorticoid-receptor translocation promoter
ATP-stimulated glucocorticoid-receptor translocaton promoter
ATP:glycerol 3-phosphotransferase
glycerokinase
NP_077357.2
XP_006257049.1
XP_006257050.1
XP_008771496.1
XP_008771497.1
XP_008771498.1
XP_008771500.1
XP_038956015.1
XP_063136391.1
XP_063136392.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024381.2 → NP_077357.2  glycerol kinase

    Status: VALIDATED

    Source sequence(s)
    CO557097, CO564445, D16102, JAXUCZ010000021
    UniProtKB/TrEMBL
    A6IPW2
    Related
    ENSRNOP00000102933.1, ENSRNOT00000158613.1
    Conserved Domains (2) summary
    cd07792
    Location:11 → 513
    FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
    TIGR01311
    Location:11 → 513
    glycerol_kin; glycerol kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    54106708..54189940 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008773276.4 → XP_008771498.1  glycerol kinase isoform X4

    UniProtKB/TrEMBL
    A6IPW2
    Conserved Domains (2) summary
    cd07792
    Location:11 → 547
    FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
    TIGR01311
    Location:11 → 547
    glycerol_kin; glycerol kinase

  2. XM_006256987.5 → XP_006257049.1  glycerol kinase isoform X5

    UniProtKB/Swiss-Prot
    A0A0G2K785, Q63060
    UniProtKB/TrEMBL
    A6IPW2
    Related
    ENSRNOP00000074103.1, ENSRNOT00000087547.3
    Conserved Domains (2) summary
    cd07792
    Location:11 → 519
    FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
    TIGR01311
    Location:11 → 519
    glycerol_kin; glycerol kinase

  3. XM_006256988.5 → XP_006257050.1  glycerol kinase isoform X7

    UniProtKB/TrEMBL
    A6IPW2
    Related
    ENSRNOP00000108996.1, ENSRNOT00000153646.1
    Conserved Domains (2) summary
    cd07792
    Location:11 → 513
    FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
    TIGR01311
    Location:11 → 513
    glycerol_kin; glycerol kinase

  4. XM_063280322.1 → XP_063136392.1  glycerol kinase isoform X9

    UniProtKB/TrEMBL
    D3ZCI0, F1LSY6
    Related
    ENSRNOP00000048795.5, ENSRNOT00000051249.7

  5. XM_063280321.1 → XP_063136391.1  glycerol kinase isoform X8

    UniProtKB/TrEMBL
    A0A8J8YI12
    Related
    ENSRNOP00000059825.2, ENSRNOT00000064340.5

  6. XM_008773275.4 → XP_008771497.1  glycerol kinase isoform X2

    UniProtKB/TrEMBL
    A6IPW2
    Conserved Domains (2) summary
    cd07792
    Location:11 → 541
    FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
    TIGR01311
    Location:11 → 541
    glycerol_kin; glycerol kinase

  7. XM_008773278.4 → XP_008771500.1  glycerol kinase isoform X6

    UniProtKB/TrEMBL
    A6IPW2
    Conserved Domains (2) summary
    cd07792
    Location:11 → 547
    FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
    TIGR01311
    Location:11 → 547
    glycerol_kin; glycerol kinase

  8. XM_008773274.4 → XP_008771496.1  glycerol kinase isoform X1

    UniProtKB/TrEMBL
    A6IPW2
    Conserved Domains (2) summary
    cd07792
    Location:11 → 547
    FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
    TIGR01311
    Location:11 → 547
    glycerol_kin; glycerol kinase

  9. XM_039100087.2 → XP_038956015.1  glycerol kinase isoform X3

    UniProtKB/TrEMBL
    A6IPW2
    Related
    ENSRNOP00000103355.1, ENSRNOT00000137012.1
    Conserved Domains (1) summary
    cd07792
    Location:11 → 547
    FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63060.2 GenPept UniProtKB/Swiss-Prot:Q63060

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