Arhgef11 Rho guanine nucleotide exchange factor 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arhgef11provided by RGD
Official Full Name: Rho guanine nucleotide exchange factor 11provided by RGD
Primary source: RGD:619705
See related: EnsemblRapid:ENSRNOG00000015026 AllianceGenome:RGD:619705
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gtrap48
Summary: Enables guanyl-nucleotide exchange factor activity. Involved in positive regulation of L-glutamate import across plasma membrane. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human ARHGEF11 (Rho guanine nucleotide exchange factor 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 90.3), Kidney (RPKM 85.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (175372269..175493852)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (173074383..173195962)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (186979850..187102523)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Arhgef11 in the Dahl Salt-Sensitive Rat Protects Against Hypertension-Induced Renal Injury.
Title: Loss of Arhgef11 in the Dahl Salt-Sensitive Rat Protects Against Hypertension-Induced Renal Injury.
Intrauterine hyperglycemia could cause obesity and abnormal glycolipid metabolism in female transgenerational offspring; the programming effect of the intrauterine environment could cause a more obvious phenotype in the maternal line. Further exploration suggested that increased expression of ARHGEF11 in the liver could be involved.
Title: Transgenerational Obesity and Alteration of ARHGEF11 in the Rat Liver Induced by Intrauterine Hyperglycemia.
genetic variants in Arhgef11 via increased expression and/or protein activity play a role in promoting kidney injury in the Dahl salt-sensitive rat through changes in cell morphology (Rho-Rock and/or EMT) that impact the function of tubule cells
Title: Allelic Variants in Arhgef11 via the Rho-Rock Pathway Are Linked to Epithelial-Mesenchymal Transition and Contributes to Kidney Injury in the Dahl Salt-Sensitive Rat.
Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.
Title: Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.
Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the Galpha(q/11)--p63RhoGEF--RhoA axis.
Title: Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the Gα(q/11)--p63RhoGEF--RhoA axis.
Data show that Arhgef11 plays an important role in the activation of the Rho-ROCK signaling pathway.
Title: Genetic variants in Arhgef11 are associated with kidney injury in the Dahl salt-sensitive rat.
Data provide for the first time evidence that p63RhoGEF is an important mediator of ANG II-dependent RhoA activation in RASMCs and therewith a leading actor in the subsequently triggered cellular processes, such as proliferation and contraction.
Title: p63RhoGEF--a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells.
Acute ethanol exposure increases EAAT4 activity at clinically relevant concentrations and that PKC and PI3K may mediate this.
Title: Ethanol increases the activity of rat excitatory amino acid transporter type 4 expressed in Xenopus oocytes: role of protein kinase C and phosphatidylinositol 3-kinase.

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General gene information

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Markers

D2Mco45 (e-PCR)
- UniSTS:239461

BI289089 (e-PCR)
- UniSTS:246676

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor binding	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of L-glutamate import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho guanine nucleotide exchange factor 11

Names: Rho guanine nucleotide exchange factor (GEF) 11; RhoGEF glutamate transport modulator GTRAP48; glutamate transporter EAAT4 associated protein 48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023982.3 → NP_076472.2 rho guanine nucleotide exchange factor 11

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

Related

ENSRNOP00000083614.2, ENSRNOT00000119098.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

175372269..175493852

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006232759.3 → XP_006232821.1 rho guanine nucleotide exchange factor 11 isoform X1

UniProtKB/TrEMBL

A0A8I6AAM2

Conserved Domains (6) summary

PRK12782
Location:269 → 358

flgC; flagellar basal body rod protein FlgC; Reviewed

cd08753
Location:347 → 491

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

COG0265
Location:78 → 154

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:63 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:997 → 1139

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

pfam00621
Location:796 → 980

RhoGEF; RhoGEF domain
XM_039103185.2 → XP_038959113.1 rho guanine nucleotide exchange factor 11 isoform X16

UniProtKB/TrEMBL

A0A8I6AAM2

Conserved Domains (6) summary

PRK12782
Location:269 → 358

flgC; flagellar basal body rod protein FlgC; Reviewed

cd08753
Location:347 → 491

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

smart00325
Location:796 → 980

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

PHA03247
Location:1291 → 1420

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:63 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:997 → 1139

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
XM_039103180.2 → XP_038959108.1 rho guanine nucleotide exchange factor 11 isoform X7

UniProtKB/Swiss-Prot

Q9ES67

Conserved Domains (6) summary

PRK12782
Location:269 → 358

flgC; flagellar basal body rod protein FlgC; Reviewed

cd08753
Location:347 → 491

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

smart00325
Location:786 → 970

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

PRK07764
Location:1124 → 1452

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:63 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:987 → 1129

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
XM_039103176.2 → XP_038959104.1 rho guanine nucleotide exchange factor 11 isoform X3

UniProtKB/TrEMBL

A0A8I6AAM2

Conserved Domains (6) summary

PRK12782
Location:269 → 358

flgC; flagellar basal body rod protein FlgC; Reviewed

cd08753
Location:347 → 491

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

smart00325
Location:795 → 979

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

PRK07764
Location:1142 → 1461

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:63 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:996 → 1138

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
XM_039103181.2 → XP_038959109.1 rho guanine nucleotide exchange factor 11 isoform X8

UniProtKB/Swiss-Prot

Q9ES67

Related

ENSRNOP00000086176.2, ENSRNOT00000114540.2

Conserved Domains (6) summary

PRK12782
Location:269 → 358

flgC; flagellar basal body rod protein FlgC; Reviewed

cd08753
Location:347 → 491

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

smart00325
Location:785 → 969

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

PRK07764
Location:1123 → 1451

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:63 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:986 → 1128

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
XM_039103188.2 → XP_038959116.1 rho guanine nucleotide exchange factor 11 isoform X20

UniProtKB/TrEMBL

A0A8I6AAM2

Conserved Domains (5) summary

cd08753
Location:301 → 445

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

smart00325
Location:750 → 934

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

PRK07764
Location:1088 → 1416

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:63 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:951 → 1093

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
XM_039103184.2 → XP_038959112.1 rho guanine nucleotide exchange factor 11 isoform X17

UniProtKB/Swiss-Prot

Q9ES67

Conserved Domains (6) summary

PRK12782
Location:229 → 318

flgC; flagellar basal body rod protein FlgC; Reviewed

cd08753
Location:307 → 451

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

smart00325
Location:756 → 940

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

PRK07764
Location:1094 → 1422

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:63 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:957 → 1099

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
XM_039103189.2 → XP_038959117.1 rho guanine nucleotide exchange factor 11 isoform X25

UniProtKB/Swiss-Prot

Q9ES67

Conserved Domains (5) summary

cd08753
Location:261 → 405

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

smart00325
Location:710 → 894

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

PRK07764
Location:1048 → 1376

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:63 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:911 → 1053

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
XM_039103177.2 → XP_038959105.1 rho guanine nucleotide exchange factor 11 isoform X2

UniProtKB/TrEMBL

A0A8I6AAM2

Conserved Domains (6) summary

PRK12782
Location:268 → 357

flgC; flagellar basal body rod protein FlgC; Reviewed

cd08753
Location:346 → 490

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

smart00325
Location:795 → 979

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

PRK07764
Location:1133 → 1461

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:62 → 127

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:996 → 1138

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
XM_039103178.2 → XP_038959106.1 rho guanine nucleotide exchange factor 11 isoform X4

UniProtKB/TrEMBL

A0A8I6AAM2

Conserved Domains (6) summary

PRK12782
Location:268 → 357

flgC; flagellar basal body rod protein FlgC; Reviewed

cd08753
Location:346 → 490

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

smart00325
Location:794 → 978

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

PRK07764
Location:1132 → 1460

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:62 → 127

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:995 → 1137

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
XM_039103182.2 → XP_038959110.1 rho guanine nucleotide exchange factor 11 isoform X9

UniProtKB/Swiss-Prot

Q9ES67

Conserved Domains (6) summary

PRK12782
Location:268 → 357

flgC; flagellar basal body rod protein FlgC; Reviewed

cd08753
Location:346 → 490

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

smart00325
Location:784 → 968

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

PRK07764
Location:1122 → 1450

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:62 → 127

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:985 → 1127

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
XM_039103186.2 → XP_038959114.1 rho guanine nucleotide exchange factor 11 isoform X18

UniProtKB/Swiss-Prot

Q9ES67

Conserved Domains (6) summary

PRK12782
Location:228 → 317

flgC; flagellar basal body rod protein FlgC; Reviewed

cd08753
Location:306 → 450

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

smart00325
Location:755 → 939

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

PRK07764
Location:1093 → 1421

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:62 → 127

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:956 → 1098

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
XM_039103187.2 → XP_038959115.1 rho guanine nucleotide exchange factor 11 isoform X19

UniProtKB/Swiss-Prot

Q9ES67

Conserved Domains (6) summary

PRK12782
Location:228 → 317

flgC; flagellar basal body rod protein FlgC; Reviewed

cd08753
Location:306 → 450

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

smart00325
Location:754 → 938

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

PRK07764
Location:1101 → 1420

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:62 → 127

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:955 → 1097

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
XM_017591126.3 → XP_017446615.1 rho guanine nucleotide exchange factor 11 isoform X5

UniProtKB/TrEMBL

A0A8I6AAM2
XM_063282598.1 → XP_063138668.1 rho guanine nucleotide exchange factor 11 isoform X10

Related

ENSRNOP00000086384.2, ENSRNOT00000106820.2
XM_039103179.2 → XP_038959107.1 rho guanine nucleotide exchange factor 11 isoform X6

UniProtKB/TrEMBL

A0A8I6AAM2

Conserved Domains (6) summary

PRK12782
Location:263 → 352

flgC; flagellar basal body rod protein FlgC; Reviewed

cd08753
Location:341 → 485

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

smart00325
Location:790 → 974

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

PRK07764
Location:1128 → 1456

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:57 → 122

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:991 → 1133

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
XM_006232766.3 → XP_006232828.1 rho guanine nucleotide exchange factor 11 isoform X11

UniProtKB/TrEMBL

A0A8I6A5B5, A0A8I6AAM2

Related

ENSRNOP00000088812.2, ENSRNOT00000116714.2

Conserved Domains (6) summary

PRK12782
Location:253 → 342

flgC; flagellar basal body rod protein FlgC; Reviewed

cd08753
Location:331 → 475

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

COG0265
Location:62 → 138

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00992
Location:47 → 112

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:981 → 1123

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

pfam00621
Location:780 → 964

RhoGEF; RhoGEF domain
XM_063282600.1 → XP_063138670.1 rho guanine nucleotide exchange factor 11 isoform X14

UniProtKB/TrEMBL

A0A8I6A8L7
XM_063282599.1 → XP_063138669.1 rho guanine nucleotide exchange factor 11 isoform X12

Related

ENSRNOP00000020717.8, ENSRNOT00000020717.9
XM_063282601.1 → XP_063138671.1 rho guanine nucleotide exchange factor 11 isoform X15
XM_063282602.1 → XP_063138672.1 rho guanine nucleotide exchange factor 11 isoform X21

Related

ENSRNOP00000108218.1, ENSRNOT00000157908.1
XM_063282604.1 → XP_063138674.1 rho guanine nucleotide exchange factor 11 isoform X23

Related

ENSRNOP00000070996.3, ENSRNOT00000091336.3
XM_063282603.1 → XP_063138673.1 rho guanine nucleotide exchange factor 11 isoform X22
XM_063282605.1 → XP_063138675.1 rho guanine nucleotide exchange factor 11 isoform X24
XM_039103183.2 → XP_038959111.1 rho guanine nucleotide exchange factor 11 isoform X13

UniProtKB/TrEMBL

A0A8I6AAM2

Conserved Domains (6) summary

PRK12782
Location:252 → 341

flgC; flagellar basal body rod protein FlgC; Reviewed

cd08753
Location:330 → 474

RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein

smart00325
Location:779 → 963

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

PRK07764
Location:1117 → 1445

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00992
Location:46 → 111

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13391
Location:980 → 1122

PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
XM_063282606.1 → XP_063138676.1 rho guanine nucleotide exchange factor 11 isoform X26