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PRDM2 PR/SET domain 2 [ Homo sapiens (human) ]

Gene ID: 7799, updated on 28-Oct-2024

Summary

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Official Symbol
PRDM2provided by HGNC
Official Full Name
PR/SET domain 2provided by HGNC
Primary source
HGNC:HGNC:9347
See related
Ensembl:ENSG00000116731 MIM:601196; AllianceGenome:HGNC:9347
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIZ; KMT8; RIZ1; RIZ2; KMT8A; MTB-ZF; HUMHOXY1
Summary
This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 10.7), ovary (RPKM 8.6) and 25 other tissues See more
Orthologs
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Genomic context

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See PRDM2 in Genome Data Viewer
Location:
1p36.21
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (13700188..13825079)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (13142270..13267189)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (14026683..14151574)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376756 Neighboring gene small Cajal body-specific RNA 11 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 288 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 215 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 219 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:14075835-14076053 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 290 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 220 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:14107388-14107556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 221 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:14119276-14119776 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:14128246-14129019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:14130567-14131339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:14129793-14130566 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 291 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 222 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:14170707-14171281 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_267 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:14273321-14273553 Neighboring gene kazrin, periplakin interacting protein Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_268 Neighboring gene MPRA-validated peak76 silencer Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:14462209-14462755 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:14462756-14463301 Neighboring gene RNA, U6 small nuclear 1265, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:14493737-14494238 Neighboring gene uncharacterized LOC107985467

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Anticancer activity of the PR domain of tumor suppressor RIZ1. Sun W, et al. Int J Med Sci, 2011 Feb 21. PMID 21369371, Free PMC Article
  2. The Zn-finger domain of RIZ protein promotes MCF-7 cell proliferation. Rossi M, et al. Cancer Lett, 2004 Nov 25. PMID 15488642
  3. Aberrant Methylation of the 1p36 Tumor Suppressor Gene RIZ1 in Renal Cell Carcinoma. Ge P, et al. Asian Pac J Cancer Prev, 2015. PMID 25987089
  4. Lower PRDM2 expression is associated with dopamine-agonist resistance and tumor recurrence in prolactinomas. Gao H, et al. BMC Cancer, 2015 Apr 12. PMID 25884948, Free PMC Article
  5. Deletions and altered expression of the RIZ1 tumour suppressor gene in 1p36 in pheochromocytomas and abdominal paragangliomas. Geli J, et al. Int J Oncol, 2005 May. PMID 15809732

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RIZ2 at the crossroad of the EGF/EGFR signaling in colorectal cancer.
    Title: RIZ2 at the crossroad of the EGF/EGFR signaling in colorectal cancer.
  2. Exploring the putative role of PRDM1 and PRDM2 transcripts as mediators of T lymphocyte activation.
    Title: Exploring the putative role of PRDM1 and PRDM2 transcripts as mediators of T lymphocyte activation.
  3. PRDM2 negatively regulated the expression of c-Myc in somatotroph adenomas, and testified the synergism between PRDM2 gene therapy and c-Myc inhibitor in vitro experiment
    Title: The absence of PRDM2 involved the tumorigenesis of somatotroph adenomas through regulating c-Myc.
  4. The authors have found that overexpression of RIZ1 in HEK293 cells reduced the expression of Akt3 protein.
    Title: Repression of Akt3 gene transcription by the tumor suppressor RIZ1.
  5. Promoter hypermethylation may play an important role in the epigenetic silencing of RIZ1 expression in human glioma tissues and glioblastoma cell lines.
    Title: Methylation Status of the RIZ1 Gene Promoter in Human Glioma Tissues and Cell Lines.
  6. the Pro704 p-/- allele of RIZ is significantly more common in CML patients with Loss of hematological response than good responders (p = .001). We showed that LOH p-/- homozygosity of RIZ1 was common event in BC than proline p+/+ homozygosity and proline p+/+ homozygosity more common feature in CP phase CML.
    Title: A deletion polymorphism in the RIZ gene is associated with increased progression of imatinib treated chronic myeloid leukemia patients.
  7. Promoter region methylation of RIZ1 may play an important role in the epigenetic silencing of RIZ1 expression in pituitary adenomas, which may translate into important diagnostic and therapeutic applications
    Title: RIZ1 and histone methylation status in pituitary adenomas.
  8. RIZ1 expression is negatively correlated with glioma differentiation and can serve as a predictor of glioma prognosis and thus could be a potential therapeutic target for patients with gliomas.
    Title: RIZ1: a potential tumor suppressor in glioma.
  9. Loss of RIZ1 expression due to methylation is associated with Renal Cell Carcinoma.
    Title: Aberrant Methylation of the 1p36 Tumor Suppressor Gene RIZ1 in Renal Cell Carcinoma.
  10. PRDM2 downregulation may play a role in dopamine-agonist resistance and tumor recurrence in prolactinomas.
    Title: Lower PRDM2 expression is associated with dopamine-agonist resistance and tumor recurrence in prolactinomas.
Submit: New GeneRIF Correction See all GeneRIFs (52)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of PR domain containing 2, with ZNF domain (PRDM2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H3K9 trimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in determination of adult lifespan IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
PR domain zinc finger protein 2
Names
GATA-3 binding protein G3B
MTE-binding protein
PR domain 2
PR domain containing 2, with ZNF domain
PR domain-containing protein 2
lysine N-methyltransferase 8
retinoblastoma protein-binding zinc finger protein
retinoblastoma protein-interacting zinc finger protein
zinc finger protein RIZ
zinc-finger DNA-binding protein
NP_001007258.1
NP_001129082.1
NP_001380915.1
NP_001380916.1
NP_001380917.1
NP_036363.2
NP_056950.2
XP_016857749.1
XP_016857750.1
XP_047285950.1
XP_047285951.1
XP_047285952.1
XP_047285953.1
XP_047285954.1
XP_054194628.1
XP_054194629.1
XP_054194630.1
XP_054194631.1
XP_054194632.1
XP_054194633.1
XP_054194634.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007257.3 → NP_001007258.1  PR domain zinc finger protein 2 isoform c

    See identical proteins and their annotated locations for NP_001007258.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is shorter at the 5' end and differs in the 3' UTR and coding region compared to variant 1. Expression of this transcript is under the control of an internal promoter in the gene (PMID: 9006946), which is why it is shorter at the 5' end than variant 1. The resulting isoform (c, also called RIZ2) is shorter at the N-terminus and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI651991, AL031277, BC014468, BC032768, D45132, U17838
    Consensus CDS
    CCDS30603.1
    UniProtKB/TrEMBL
    Q59H82
    Related
    ENSP00000411103.1, ENST00000413440.5
    Conserved Domains (3) summary
    sd00017
    Location:935 → 955
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:161 → 181
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:159 → 181
    zf-C2H2; Zinc finger, C2H2 type

  2. NM_001135610.2 → NP_001129082.1  PR domain zinc finger protein 2 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 5' UTR and lacks two internal coding exons compared to variant 1. The resulting isoform (d) is much shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AK307377, AL031277, AL359771, BC014468, BU621515
    Consensus CDS
    CCDS44061.1
    UniProtKB/Swiss-Prot
    Q13029
    Related
    ENSP00000365216.5, ENST00000376048.9
    Conserved Domains (1) summary
    smart00317
    Location:28 → 147
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

  3. NM_001393986.1 → NP_001380915.1  PR domain zinc finger protein 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL031277, AL359771, AL583942
    Consensus CDS
    CCDS150.1
    UniProtKB/Swiss-Prot
    B1AJZ4, B5MC68, Q13029, Q13149, Q14550, Q5THJ1, Q5VUL9
    UniProtKB/TrEMBL
    Q59H82
    Related
    ENSP00000312352.6, ENST00000311066.10
    Conserved Domains (5) summary
    sd00017
    Location:1136 → 1156
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:362 → 382
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd19188
    Location:23 → 145
    PR-SET_PRDM2; PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins
    pfam00096
    Location:360 → 382
    zf-C2H2; Zinc finger, C2H2 type
    pfam13894
    Location:483 → 506
    zf-C2H2_4; C2H2-type zinc finger

  4. NM_001393987.1 → NP_001380916.1  PR domain zinc finger protein 2 isoform e

    Status: REVIEWED

    Source sequence(s)
    AL031277
    UniProtKB/TrEMBL
    Q59H82
    Conserved Domains (4) summary
    sd00017
    Location:935 → 955
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:161 → 181
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:159 → 181
    zf-C2H2; Zinc finger, C2H2 type
    pfam13894
    Location:282 → 305
    zf-C2H2_4; C2H2-type zinc finger

  5. NM_001393988.1 → NP_001380917.1  PR domain zinc finger protein 2 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL031277
    Consensus CDS
    CCDS30603.1
    UniProtKB/TrEMBL
    Q59H82
    Related
    ENSP00000341621.4, ENST00000343137.8
    Conserved Domains (3) summary
    sd00017
    Location:935 → 955
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:161 → 181
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:159 → 181
    zf-C2H2; Zinc finger, C2H2 type

  6. NM_012231.5 → NP_036363.2  PR domain zinc finger protein 2 isoform a

    See identical proteins and their annotated locations for NP_036363.2

    Status: REVIEWED

    Source sequence(s)
    AL031277, AL359771, AL583942
    Consensus CDS
    CCDS150.1
    UniProtKB/Swiss-Prot
    B1AJZ4, B5MC68, Q13029, Q13149, Q14550, Q5THJ1, Q5VUL9
    UniProtKB/TrEMBL
    Q59H82
    Related
    ENSP00000235372.6, ENST00000235372.11
    Conserved Domains (5) summary
    sd00017
    Location:1136 → 1156
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:362 → 382
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd19188
    Location:23 → 145
    PR-SET_PRDM2; PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins
    pfam00096
    Location:360 → 382
    zf-C2H2; Zinc finger, C2H2 type
    pfam13894
    Location:483 → 506
    zf-C2H2_4; C2H2-type zinc finger

  7. NM_015866.6 → NP_056950.2  PR domain zinc finger protein 2 isoform b

    See identical proteins and their annotated locations for NP_056950.2

    Status: REVIEWED

    Source sequence(s)
    AL031277, AL359771, AL583942
    UniProtKB/TrEMBL
    Q59H82
    Conserved Domains (4) summary
    smart00317
    Location:28 → 147
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    sd00017
    Location:1136 → 1156
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:362 → 382
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:360 → 382
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    13700188..13825079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429994.1 → XP_047285950.1  PR domain zinc finger protein 2 isoform X1

  2. XM_047429995.1 → XP_047285951.1  PR domain zinc finger protein 2 isoform X2

  3. XM_047429996.1 → XP_047285952.1  PR domain zinc finger protein 2 isoform X3

  4. XM_047429998.1 → XP_047285954.1  PR domain zinc finger protein 2 isoform X5

  5. XM_047429997.1 → XP_047285953.1  PR domain zinc finger protein 2 isoform X4

  6. XM_017002261.3 → XP_016857750.1  PR domain zinc finger protein 2 isoform X4

    UniProtKB/TrEMBL
    Q59H82
    Conserved Domains (4) summary
    sd00017
    Location:935 → 955
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:161 → 181
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:159 → 181
    zf-C2H2; Zinc finger, C2H2 type
    pfam13894
    Location:282 → 305
    zf-C2H2_4; C2H2-type zinc finger

  7. XM_017002260.3 → XP_016857749.1  PR domain zinc finger protein 2 isoform X4

    UniProtKB/TrEMBL
    Q59H82
    Conserved Domains (4) summary
    sd00017
    Location:935 → 955
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:161 → 181
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:159 → 181
    zf-C2H2; Zinc finger, C2H2 type
    pfam13894
    Location:282 → 305
    zf-C2H2_4; C2H2-type zinc finger

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    13142270..13267189
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338653.1 → XP_054194628.1  PR domain zinc finger protein 2 isoform X1

  2. XM_054338654.1 → XP_054194629.1  PR domain zinc finger protein 2 isoform X2

  3. XM_054338655.1 → XP_054194630.1  PR domain zinc finger protein 2 isoform X3

  4. XM_054338659.1 → XP_054194634.1  PR domain zinc finger protein 2 isoform X5

  5. XM_054338656.1 → XP_054194631.1  PR domain zinc finger protein 2 isoform X4

  6. XM_054338658.1 → XP_054194633.1  PR domain zinc finger protein 2 isoform X4

  7. XM_054338657.1 → XP_054194632.1  PR domain zinc finger protein 2 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13029.3 GenPept UniProtKB/Swiss-Prot:Q13029

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