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Vmp1 vacuole membrane protein 1 [ Mus musculus (house mouse) ]

Gene ID: 75909, updated on 2-Nov-2024

Summary

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Official Symbol
Vmp1provided by MGI
Official Full Name
vacuole membrane protein 1provided by MGI
Primary source
MGI:MGI:1923159
See related
Ensembl:ENSMUSG00000018171 AllianceGenome:MGI:1923159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ni-2; Tango5; Tmem49; mir-21a; 3110098I04Rik; 4930579A11Rik
Summary
Predicted to enable phospholipid scramblase activity. Involved in autophagy and lipoprotein transport. Acts upstream of or within embryo implantation. Located in phagophore assembly site. Orthologous to human VMP1 (vacuole membrane protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 30.4), bladder adult (RPKM 28.1) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Vmp1 in Genome Data Viewer
Location:
11 C; 11 51.82 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (86474684..86574662, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (86583858..86683836, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3004 Neighboring gene tubulin, delta 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:86395440-86395623 Neighboring gene VISTA enhancer mm127 Neighboring gene STARR-positive B cell enhancer ABC_E2362 Neighboring gene predicted gene 9975 Neighboring gene microRNA 21a Neighboring gene predicted gene, 46289 Neighboring gene STARR-positive B cell enhancer ABC_E3988 Neighboring gene predicted gene, 51914 Neighboring gene STARR-seq mESC enhancer starr_30272 Neighboring gene STARR-seq mESC enhancer starr_30273 Neighboring gene predicted gene 11478 Neighboring gene STARR-seq mESC enhancer starr_30274 Neighboring gene STARR-positive B cell enhancer ABC_E11770 Neighboring gene STARR-seq mESC enhancer starr_30275 Neighboring gene peptidyl-tRNA hydrolase 2 Neighboring gene STARR-positive B cell enhancer ABC_E3989 Neighboring gene STARR-positive B cell enhancer ABC_E7036 Neighboring gene clathrin heavy chain Neighboring gene STARR-seq mESC enhancer starr_30277 Neighboring gene predicted gene, 42085

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. VMP1 prevents Ca2+ overload in endoplasmic reticulum and maintains naive T cell survival. Liu Y, et al. J Exp Med, 2023 Jun 5. PMID 36971758, Free PMC Article
  2. VMP1 regulates hepatic lipoprotein secretion and NASH independent of autophagy. Jiang X, et al. Autophagy, 2023 Jan. PMID 35617134, Free PMC Article
  3. Loss of hepatic VMP1 trapped VLDL in the bilayer of endoplasmic reticulum membrane(☆). Ni HM, et al. Liver Res, 2023 Jun. PMID 38405163, Free PMC Article
  4. WHSC1L1-mediated epigenetic downregulation of VMP1 participates in herpes simplex virus 1 infection-induced mitophagy impairment and neuroinflammation. Yao Y, et al. Mol Immunol, 2023 Nov. PMID 37748280
  5. Loss of acinar cell VMP1 triggers spontaneous pancreatitis in mice. Wang S, et al. Autophagy, 2022 Jul. PMID 34709991, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WHSC1L1-mediated epigenetic downregulation of VMP1 participates in herpes simplex virus 1 infection-induced mitophagy impairment and neuroinflammation.
    Title: WHSC1L1-mediated epigenetic downregulation of VMP1 participates in herpes simplex virus 1 infection-induced mitophagy impairment and neuroinflammation.
  2. VMP1 prevents Ca2+ overload in endoplasmic reticulum and maintains naive T cell survival.
    Title: VMP1 prevents Ca2+ overload in endoplasmic reticulum and maintains naive T cell survival.
  3. VMP1 regulates hepatic lipoprotein secretion and NASH independent of autophagy.
    Title: VMP1 regulates hepatic lipoprotein secretion and NASH independent of autophagy.
  4. Lack of VMP1 impairs hepatic lipoprotein secretion and promotes non-alcoholic steatohepatitis.
    Title: Lack of VMP1 impairs hepatic lipoprotein secretion and promotes non-alcoholic steatohepatitis.
  5. Loss of acinar cell VMP1 triggers spontaneous pancreatitis in mice.
    Title: Loss of acinar cell VMP1 triggers spontaneous pancreatitis in mice.
  6. These results suggest that VMP1 is important for the release of lipoproteins from the endoplasmic reticulum membrane to the endoplasmic reticulum lumen in addition to its previously known functions.
    Title: A critical role of VMP1 in lipoprotein secretion.
  7. these results indicate that miR-21a negatively modulates two tumor suppressor genes, miR-200c and PTEN, thereby promoting M2 macrophage transformation
    Title: miR-21a negatively modulates tumor suppressor genes PTEN and miR-200c and further promotes the transformation of M2 macrophages.
  8. It has been concluded that VMP1-mediated autophagy cooperated with Kras to promote pancreatic ductal adenocarcinoma initiation.
    Title: The pancreatitis-associated protein VMP1, a key regulator of inducible autophagy, promotes Kras(G12D)-mediated pancreatic cancer initiation.
  9. VMP1 modulates SERCA2 activity to control endoplasmic reticulum contacts for autophagosome formation.
    Title: The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation.
  10. AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells.
    Title: Novel AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phospholipid scramblase activity ISO
Inferred from Sequence Orthology
more info
  
enables phospholipid scramblase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in autophagosome membrane docking ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagosome membrane docking ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in autophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in cell junction assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cell junction assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within embryo implantation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipoprotein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipoprotein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion-endoplasmic reticulum membrane tethering ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion-endoplasmic reticulum membrane tethering ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in organelle localization by membrane tethering ISO
Inferred from Sequence Orthology
more info
  
involved_in organelle localization by membrane tethering ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in plasma membrane phospholipid scrambling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ATPase-coupled calcium transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ATPase-coupled calcium transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in autophagosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in autophagosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in phagophore assembly site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
vacuole membrane protein 1
Names
NF-E2 induceble protein-2
protein ni-2
transmembrane protein 49

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356531.3 → NP_001343460.1  vacuole membrane protein 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variants 1 and 3, encodes isoform a.
    Source sequence(s)
    AL592222, AL604063
    Consensus CDS
    CCDS25203.1
    UniProtKB/Swiss-Prot
    A2V655, Q3TX07, Q8BHD3, Q99KU0
    Conserved Domains (1) summary
    cl00429
    Location:247 → 298
    SNARE_assoc; SNARE associated Golgi protein

  2. NM_001379040.1 → NP_001365969.1  vacuole membrane protein 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (a). Variants 1-3 all encode the same isoform (a).
    Source sequence(s)
    AL592222, AL604063
    UniProtKB/Swiss-Prot
    A2V655, Q3TX07, Q8BHD3, Q99KU0
    Conserved Domains (1) summary
    cl00429
    Location:247 → 298
    SNARE_assoc; SNARE associated Golgi protein

  3. NM_001379041.1 → NP_001365970.1  vacuole membrane protein 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL592222, AL604063
    Conserved Domains (1) summary
    cl00429
    Location:247 → 298
    SNARE_assoc; SNARE associated Golgi protein

  4. NM_029478.6 → NP_083754.2  vacuole membrane protein 1 isoform a

    See identical proteins and their annotated locations for NP_083754.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variants 2 and 3, encodes isoform a.
    Source sequence(s)
    AL592222, AL604063
    Consensus CDS
    CCDS25203.1
    UniProtKB/Swiss-Prot
    A2V655, Q3TX07, Q8BHD3, Q99KU0
    Related
    ENSMUSP00000018315.4, ENSMUST00000018315.10
    Conserved Domains (1) summary
    cl00429
    Location:247 → 298
    SNARE_assoc; SNARE associated Golgi protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    86474684..86574662 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99KU0.2 GenPept UniProtKB/Swiss-Prot:Q99KU0

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