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ZNF2 zinc finger protein 2 [ Homo sapiens (human) ]

Gene ID: 7549, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF2provided by HGNC
Official Full Name
zinc finger protein 2provided by HGNC
Primary source
HGNC:HGNC:12991
See related
Ensembl:ENSG00000275111 MIM:194500; AllianceGenome:HGNC:12991
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A1-5; ZNF661; Zfp661
Summary
The protein encoded by this gene belongs to the C2H2-type zinc-finger protein family. The exact function of this gene is not known, however, zinc-finger proteins are known to interact with DNA and function as transcription regulators. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Expression
Ubiquitous expression in testis (RPKM 1.8), thyroid (RPKM 1.6) and 25 other tissues See more
Orthologs
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Genomic context

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See ZNF2 in Genome Data Viewer
Location:
2q11.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (95165809..95184317)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (95672291..95690797)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (95831554..95850065)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr2:95753198-95753763 Neighboring gene mitochondrial ribosomal protein S5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11739 Neighboring gene zinc finger protein 514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11740 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:95830542-95831178 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:95831179-95831813 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95843643-95844143 Neighboring gene zinc finger protein 2-like Neighboring gene solute carrier family 2 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The Krüppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression. Witzgall R, et al. Proc Natl Acad Sci U S A, 1994 May 10. PMID 8183940, Free PMC Article
  2. The human KRAB/FPB containing zinc finger gene ZNF2 maps to chromosome 2q11.2. Rocchi M, et al. Cytogenet Cell Genet, 1999. PMID 10575230
  3. Expression, purification and partial characterization of the Krüppel-associated box (KRAB) from the human ZNF2 protein. Rivieccio V, et al. Protein Pept Lett, 2005 Aug. PMID 16101389
  4. Members of the zinc finger protein gene family sharing a conserved N-terminal module. Rosati M, et al. Nucleic Acids Res, 1991 Oct 25. PMID 1945843, Free PMC Article
  5. A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins. Kim SS, et al. Proc Natl Acad Sci U S A, 1996 Dec 24. PMID 8986806, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 2
Names
zinc finger protein 2.2
zinc finger protein 661

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033798.1 RefSeqGene

    Range
    5393..23901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001017396.3 → NP_001017396.1  zinc finger protein 2 isoform b

    See identical proteins and their annotated locations for NP_001017396.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a.
    Source sequence(s)
    AC092835, AI631860, AK295739, AV726545, X60152
    Consensus CDS
    CCDS42713.1
    UniProtKB/Swiss-Prot
    Q9BSG1
    UniProtKB/TrEMBL
    B0AZN8
    Related
    ENSP00000480057.1, ENST00000617923.4
    Conserved Domains (5) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:144 → 370
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:189 → 209
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:299 → 321
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145 → 170
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001282398.2 → NP_001269327.1  zinc finger protein 2 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC092835, AI631860, AK295739, AV726545, X60152
    Consensus CDS
    CCDS62957.1
    UniProtKB/Swiss-Prot
    Q9BSG1
    UniProtKB/TrEMBL
    A0A087X063
    Related
    ENSP00000483131.1, ENST00000622059.4
    Conserved Domains (6) summary
    smart00349
    Location:14 → 60
    KRAB; krueppel associated box
    COG5048
    Location:148 → 374
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:193 → 213
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:136 → 157
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:149 → 174
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001291604.2 → NP_001278533.1  zinc finger protein 2 isoform d

    See identical proteins and their annotated locations for NP_001278533.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AC092835, AI631860, CR749650
    Consensus CDS
    CCDS77435.1
    UniProtKB/TrEMBL
    Q68CY6
    Related
    ENSP00000477960.1, ENST00000611463.1
    Conserved Domains (3) summary
    COG5048
    Location:106 → 332
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:151 → 171
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:107 → 132
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001291605.2 → NP_001278534.1  zinc finger protein 2 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (e) is longer than isoform a.
    Source sequence(s)
    AC092835, AI631860, AK299058, DA497792, KF459620
    Consensus CDS
    CCDS77434.1
    UniProtKB/TrEMBL
    A0A087WYR5
    Related
    ENSP00000482030.1, ENST00000611147.1
    Conserved Domains (6) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:199 → 425
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:244 → 264
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:187 → 208
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:200 → 225
    zf-H2C2_2; Zinc-finger double domain

  5. NM_021088.4 → NP_066574.2  zinc finger protein 2 isoform a

    See identical proteins and their annotated locations for NP_066574.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AC092835, AI631860, AK295739, AV726545, BC005068
    Consensus CDS
    CCDS42712.1
    UniProtKB/Swiss-Prot
    A8MWV7, B0AZN8, B4DIR4, Q4ZFY6, Q96G44, Q9BSG1, Q9UMC5
    Related
    ENSP00000480297.1, ENST00000614034.5
    Conserved Domains (4) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:186 → 412
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:231 → 251
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:174 → 195
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    95165809..95184317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    95672291..95690797
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BSG1.5 GenPept UniProtKB/Swiss-Prot:Q9BSG1

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