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VASP vasodilator stimulated phosphoprotein [ Homo sapiens (human) ]

Gene ID: 7408, updated on 14-Nov-2024

Summary

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Official Symbol
VASPprovided by HGNC
Official Full Name
vasodilator stimulated phosphoproteinprovided by HGNC
Primary source
HGNC:HGNC:12652
See related
Ensembl:ENSG00000125753 MIM:601703; AllianceGenome:HGNC:12652
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in appendix (RPKM 50.6), spleen (RPKM 48.4) and 25 other tissues See more
Orthologs
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Genomic context

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See VASP in Genome Data Viewer
Location:
19q13.32
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (45507479..45526983)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (48334741..48354257)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46010737..46030241)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10772 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10773 Neighboring gene reticulon 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10774 Neighboring gene uncharacterized LOC107985314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10775 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10776 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:46010402-46011186 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10778 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10779 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1N (putative) Neighboring gene uncharacterized LOC107985315 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:46025801-46026353 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10780 Neighboring gene outer mitochondrial membrane lipid metabolism regulator OPA3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46056279-46056909 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46056910-46057539 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46061287-46061787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46065110-46065908 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46066707-46067504 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr19:46067505-46068302 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr19:46080520-46081155 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:46084233-46084733 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46085233-46086168 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46086169-46087104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46100634-46101271 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46101272-46101908 Neighboring gene G protein-coupled receptor 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Natriuretic peptides induce weak VASP phosphorylation at Serine 239 in platelets. Borgognone A, et al. Platelets, 2014. PMID 23469931, Free PMC Article
  2. VASP involvement in force-mediated adherens junction strengthening. Kris AS, et al. Biochem Biophys Res Commun, 2008 Oct 10. PMID 18680720, Free PMC Article
  3. Evaluation of the antiplatelet effects of cilostazol, a phosphodiesterase 3 inhibitor, by VASP phosphorylation and platelet aggregation. Yamamoto H, et al. Circ J, 2008 Nov. PMID 18832777
  4. Flow cytometric assessment of vasodilator-stimulated phosphoprotein: prognostic value of recurrent cardiovascular events after acute coronary syndromes. Cayla G, et al. Arch Cardiovasc Dis, 2008 Nov-Dec. PMID 19059569
  5. Clopidogrel 150 mg/day to overcome low responsiveness in patients undergoing elective percutaneous coronary intervention: results from the VASP-02 (Vasodilator-Stimulated Phosphoprotein-02) randomized study. Aleil B, et al. JACC Cardiovasc Interv, 2008 Dec. PMID 19463377

See all (239) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PKCzeta phosphorylates VASP to mediate chemotaxis in breast cancer cells.
    Title: PKCζ phosphorylates VASP to mediate chemotaxis in breast cancer cells.
  2. Expression of the phagocytic receptors alphaMbeta2 and alphaXbeta2 is controlled by RIAM, VASP and Vinculin in neutrophil-differentiated HL-60 cells.
    Title: Expression of the phagocytic receptors α(M)β(2) and α(X)β(2) is controlled by RIAM, VASP and Vinculin in neutrophil-differentiated HL-60 cells.
  3. Arp2/3 and Mena/VASP Require Profilin 1 for Actin Network Assembly at the Leading Edge.
    Title: Arp2/3 and Mena/VASP Require Profilin 1 for Actin Network Assembly at the Leading Edge.
  4. Up-regulation of SNHG15 facilitates cell proliferation, migration, invasion and suppresses cell apoptosis in breast cancer by regulating miR-411-5p/VASP axis.
    Title: Up-regulation of SNHG15 facilitates cell proliferation, migration, invasion and suppresses cell apoptosis in breast cancer by regulating miR-411-5p/VASP axis.
  5. RIAM-VASP Module Relays Integrin Complement Receptors in Outside-In Signaling Driving Particle Engulfment.
    Title: RIAM-VASP Module Relays Integrin Complement Receptors in Outside-In Signaling Driving Particle Engulfment.
  6. Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
    Title: Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
  7. Depletion of LAMP3 enhances PKA-mediated VASP phosphorylation to suppress invasion and metastasis in esophageal squamous cell carcinoma.
    Title: Depletion of LAMP3 enhances PKA-mediated VASP phosphorylation to suppress invasion and metastasis in esophageal squamous cell carcinoma.
  8. Transfer of HTLV-1 p8 and Gag to target T-cells depends on VASP, a novel interaction partner of p8.
    Title: Transfer of HTLV-1 p8 and Gag to target T-cells depends on VASP, a novel interaction partner of p8.
  9. ANGPTL3 inhibits renal cell carcinoma metastasis by inhibiting VASP phosphorylation.
    Title: ANGPTL3 inhibits renal cell carcinoma metastasis by inhibiting VASP phosphorylation.
  10. this study highlights the important roles of BLACAT1/miR-605-3p/VASP axis in glioma progression.
    Title: LncRNA BLACAT1 regulates VASP expression via binding to miR-605-3p and promotes giloma development.
Submit: New GeneRIF Correction See all GeneRIFs (109)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables cadherin binding HDA PubMed 
enables profilin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables profilin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neural tube closure IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein homotetramerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton TAS
Traceable Author Statement
more info
 PubMed 
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in filopodium membrane IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion HDA PubMed 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
vasodilator-stimulated phosphoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003370.4 → NP_003361.1  vasodilator-stimulated phosphoprotein

    See identical proteins and their annotated locations for NP_003361.1

    Status: REVIEWED

    Source sequence(s)
    BC038224, BG751094, Z46389
    Consensus CDS
    CCDS33051.1
    UniProtKB/Swiss-Prot
    B2RBT9, P50552, Q6PIZ1, Q93035
    UniProtKB/TrEMBL
    A0A024R0V4, A0A0S2Z4I9
    Related
    ENSP00000245932.5, ENST00000245932.11
    Conserved Domains (2) summary
    cd01207
    Location:5 → 113
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:342 → 376
    VASP_tetra; VASP tetramerization domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    45507479..45526983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259200.3 → XP_005259257.1  vasodilator-stimulated phosphoprotein isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z4I9
    Conserved Domains (2) summary
    cd01207
    Location:5 → 113
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:341 → 375
    VASP_tetra; VASP tetramerization domain

  2. XM_005259199.3 → XP_005259256.1  vasodilator-stimulated phosphoprotein isoform X1

    See identical proteins and their annotated locations for XP_005259256.1

    UniProtKB/TrEMBL
    A0A0S2Z4I9
    Related
    ENSP00000516196.1, ENST00000705986.1
    Conserved Domains (2) summary
    cd01207
    Location:5 → 113
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:341 → 375
    VASP_tetra; VASP tetramerization domain

  3. XM_017027200.3 → XP_016882689.1  vasodilator-stimulated phosphoprotein isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z4I9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    48334741..48354257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321942.1 → XP_054177917.1  vasodilator-stimulated phosphoprotein isoform X2

  2. XM_054321941.1 → XP_054177916.1  vasodilator-stimulated phosphoprotein isoform X1

  3. XM_054321943.1 → XP_054177918.1  vasodilator-stimulated phosphoprotein isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001008736.1: Suppressed sequence

    Description
    NM_001008736.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50552.3 GenPept UniProtKB/Swiss-Prot:P50552

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