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UGT2B10 UDP glucuronosyltransferase family 2 member B10 [ Homo sapiens (human) ]

Gene ID: 7365, updated on 2-Nov-2024

Summary

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Official Symbol
UGT2B10provided by HGNC
Official Full Name
UDP glucuronosyltransferase family 2 member B10provided by HGNC
Primary source
HGNC:HGNC:12544
See related
Ensembl:ENSG00000109181 MIM:600070; AllianceGenome:HGNC:12544
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UDPGT2B10
Summary
Predicted to enable UDP-glycosyltransferase activity. Predicted to be involved in cellular glucuronidation and estrogen metabolic process. Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward liver (RPKM 194.6) See more
Orthologs
all
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Genomic context

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See UGT2B10 in Genome Data Viewer
Location:
4q13.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (68815994..68832023)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (72257030..72273059)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (69681712..69697741)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase family 2 member A3 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member B17 pseudogene Neighboring gene UDP-glucuronosyltransferase 2B10-like Neighboring gene SPOPL pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:69769570-69770462 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:69771354-69772245 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:69772246-69773136 Neighboring gene uncharacterized LOC124900853 Neighboring gene UDP-glucuronosyltransferase 2B10-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism. Chen G, et al. Cancer Res, 2007 Oct 1. PMID 17909004
  2. UGT2B10 genotype influences nicotine glucuronidation, oxidation, and consumption. Berg JZ, et al. Cancer Epidemiol Biomarkers Prev, 2010 Jun. PMID 20501767, Free PMC Article
  3. Expression levels of uridine 5'-diphospho-glucuronosyltransferase genes in breast tissue from healthy women are associated with mammographic density. Haakensen VD, et al. Breast Cancer Res, 2010. PMID 20799965, Free PMC Article
  4. Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines. Chen G, et al. Pharmacogenet Genomics, 2008 Mar. PMID 18300939
  5. Nicotine N-glucuronidation relative to N-oxidation and C-oxidation and UGT2B10 genotype in five ethnic/racial groups. Murphy SE, et al. Carcinogenesis, 2014 Nov. PMID 25233931, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UGT2B10 Genotype Influences Serum Cotinine Levels and Is a Primary Determinant of Higher Cotinine in African American Smokers.
    Title: UGT2B10 Genotype Influences Serum Cotinine Levels and Is a Primary Determinant of Higher Cotinine in African American Smokers.
  2. a cis-regulatory SNP for human UGT2B10
    Title: rs294775 is a cis-regulatory SNP for human UGT2B10.
  3. The high prevalence of a UGT2B10 splice variant among African Americans results in lower 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), - N-glucuronidation but only a small decrease in total NNAL glucuronidation. Therefore, despite the significant contribution of UGT2B10 to NNAL- N-glucuronidation, the UGT2B10 genotype does not play a large role in NNAL detoxication.
    Title: Influence of UGT2B10 Genotype on Urinary Excretion of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol- N-glucuronide by African American Smokers.
  4. UGT2B10 was for the first time identified as an N-glucosidation enzyme. Generated N-glucosides were excreted primarily by the BCRP transporter.
    Title: Disposition of Mianserin and Cyclizine in UGT2B10-Overexpressing Human Embryonic Kidney 293 Cells: Identification of UGT2B10 as a Novel N-Glucosidation Enzyme and Breast Cancer Resistance Protein as an N-Glucoside Transporter.
  5. A significant contribution of AS in the regulation of UGT2B10 expression in the liver.
    Title: Post-transcriptional Regulation of UGT2B10 Hepatic Expression and Activity by Alternative Splicing.
  6. UGT2B10 activity or genotype should be considered when using cotinine as a tobacco exposure biomarker, particularly in populations such as African American with high frequencies of UGT2B10 nonfunctional variants.
    Title: Low Cotinine Glucuronidation Results in Higher Serum and Saliva Cotinine in African American Compared to White Smokers.
  7. Spatial features influence the potency of UGT2B10 inhibition.
    Title: Human UDP-Glucuronosyltransferase (UGT) 2B10: Validation of Cotinine as a Selective Probe Substrate, Inhibition by UGT Enzyme-Selective Inhibitors and Antidepressant and Antipsychotic Drugs, and Structural Determinants of Enzyme Inhibition.
  8. UGT2B10 variant allele carriers had increased levels of C-oxidation (P = 0.0099)and all pathways should be considered when characterizing the role of nicotine metabolism on smoking behavior and cancer risk.
    Title: Nicotine N-glucuronidation relative to N-oxidation and C-oxidation and UGT2B10 genotype in five ethnic/racial groups.
  9. CYP2A6 and UGT2B10 genotype explain 53% of the variance in oral nicotine glucuronidation. They are also significantly associated with undeuterated (D0) nicotine glucuronidation in individuals smoking ad libitum.
    Title: The contribution of common UGT2B10 and CYP2A6 alleles to variation in nicotine glucuronidation among European Americans.
  10. the substrate specificity of UGT2B10, highlighting its preference for tertiary amines with higher affinities and clearance values than those of UGT1A4 and UGT1A3.
    Title: Human UDP-glucuronosyltransferase (UGT) 2B10 in drug N-glucuronidation: substrate screening and comparison with UGT1A3 and UGT1A4.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
The Contribution of Common Genetic Variation to Nicotine and Cotinine Glucuronidation in Multiple Ethnic/Racial Populations.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC142209

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables UDP-glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables glucuronosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular glucuronidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in estrogen metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid metabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UDP-glucuronosyltransferase 2B10
Names
UDP glucuronosyltransferase 2 family, polypeptide B10
UDPGT 2B10
NP_001066.1
NP_001138239.1
NP_001277020.1
XP_016864074.1
XP_054184518.1
XP_054184519.1
XP_054206767.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001075.6 → NP_001066.1  UDP-glucuronosyltransferase 2B10 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001066.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC021146, AK292738, BC113649
    Consensus CDS
    CCDS75136.1
    UniProtKB/Swiss-Prot
    A8K9M3, B4DPP1, P36537, Q14CR8
    UniProtKB/TrEMBL
    Q53GQ9, Q53GU2
    Related
    ENSP00000265403.7, ENST00000265403.12
    Conserved Domains (1) summary
    pfam00201
    Location:23 → 524
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

  2. NM_001144767.3 → NP_001138239.1  UDP-glucuronosyltransferase 2B10 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001138239.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC021146, AK298432, BC113649
    Consensus CDS
    CCDS75135.1
    UniProtKB/TrEMBL
    Q53GQ9, Q53GU2
    Related
    ENSP00000413420.2, ENST00000458688.2
    Conserved Domains (3) summary
    PHA03392
    Location:184 → 422
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:23 → 440
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
    cl21454
    Location:39 → 82
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. NM_001290091.2 → NP_001277020.1  UDP-glucuronosyltransferase 2B10 isoform 3

    See identical proteins and their annotated locations for NP_001277020.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC021146, BC113649, CD013994
    Conserved Domains (2) summary
    PHA03392
    Location:20 → 258
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:1 → 276
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    68815994..68832023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008585.3 → XP_016864074.1  UDP-glucuronosyltransferase 2B10 isoform X1

    UniProtKB/TrEMBL
    Q53GQ9, Q53GU2

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_167250.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    392000..408042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328543.1 → XP_054184518.1  UDP-glucuronosyltransferase 2B10 isoform X1

  2. XM_054328544.1 → XP_054184519.1  UDP-glucuronosyltransferase 2B10 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    72257030..72273059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350792.1 → XP_054206767.1  UDP-glucuronosyltransferase 2B10 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36537.1 GenPept UniProtKB/Swiss-Prot:P36537

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