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ZNF736 zinc finger protein 736 [ Homo sapiens (human) ]

Gene ID: 728927, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF736provided by HGNC
Official Full Name
zinc finger protein 736provided by HGNC
Primary source
HGNC:HGNC:32467
See related
Ensembl:ENSG00000234444 AllianceGenome:HGNC:32467
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 3.1), bone marrow (RPKM 2.4) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF736 in Genome Data Viewer
Location:
7q11.21
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (64313961..64356634)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (65521810..65564509)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (63774339..63817012)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375323 Neighboring gene uncharacterized LOC105375322 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26055 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26057 Neighboring gene MPRA-validated peak6529 silencer Neighboring gene tripartite motif containing 60 pseudogene 18 Neighboring gene uncharacterized LOC105375321 Neighboring gene uncharacterized LOC105375324

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
  2. A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition. Benslimane Y, et al. Aging Cell, 2021 Apr. PMID 33660365, Free PMC Article
  3. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ43489, FLJ44406, DKFZp781H0161

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 736
Names
KRAB-containing zinc-finger repressor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170905.3 → NP_001164376.1  zinc finger protein 736 isoform 1

    See identical proteins and their annotated locations for NP_001164376.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1), which contains the zinc finger domains.
    Source sequence(s)
    AC073270, AK301806, DB048979
    Consensus CDS
    CCDS55114.1
    UniProtKB/Swiss-Prot
    B4DX44
    Related
    ENSP00000400852.1, ENST00000423484.3
    Conserved Domains (4) summary
    smart00349
    Location:4 → 63
    KRAB; krueppel associated box
    COG5048
    Location:227 → 383
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:287 → 307
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:383 → 405
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001294255.2 → NP_001281184.1  zinc finger protein 736 isoform 2

    See identical proteins and their annotated locations for NP_001281184.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon and its transcription extends past a splice junction used in variant 1, resulting in a different 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC073270, BC031335, DB048979
    Related
    ENST00000488621.1
    Conserved Domains (2) summary
    smart00349
    Location:4 → 63
    KRAB; krueppel associated box
    pfam01352
    Location:4 → 43
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    64313961..64356634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    65521810..65564509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B4DX44.2 GenPept UniProtKB/Swiss-Prot:B4DX44

Gene LinkOut

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