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Fndc3b fibronectin type III domain containing 3B [ Mus musculus (house mouse) ]

Gene ID: 72007, updated on 2-Nov-2024

Summary

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Official Symbol
Fndc3bprovided by MGI
Official Full Name
fibronectin type III domain containing 3Bprovided by MGI
Primary source
MGI:MGI:1919257
See related
Ensembl:ENSMUSG00000039286 AllianceGenome:MGI:1919257
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fad104; mKIAA4164; 1600019O04Rik
Summary
Acts upstream of or within several processes, including negative regulation of osteoblast differentiation; substrate adhesion-dependent cell spreading; and type II pneumocyte differentiation. Located in endoplasmic reticulum. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; nervous system; and respiratory system. Orthologous to human FNDC3B (fibronectin type III domain containing 3B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 16.1), limb E14.5 (RPKM 9.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Fndc3b in Genome Data Viewer
Location:
3 A3; 3 10.91 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (27470284..27765469, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (27416135..27711307, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor (ligand) superfamily, member 10 Neighboring gene STARR-seq mESC enhancer starr_07235 Neighboring gene STARR-seq mESC enhancer starr_07236 Neighboring gene growth hormone secretagogue receptor Neighboring gene STARR-seq mESC enhancer starr_07237 Neighboring gene predicted gene, 32738 Neighboring gene STARR-positive B cell enhancer ABC_E7905 Neighboring gene microRNA 3092 Neighboring gene STARR-seq mESC enhancer starr_07240 Neighboring gene STARR-seq mESC enhancer starr_07245 Neighboring gene STARR-seq mESC enhancer starr_07248 Neighboring gene predicted gene, 42194 Neighboring gene predicted gene, 32795 Neighboring gene transmembrane protein 212 Neighboring gene predicted gene, 26040

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FNDC3B protects steatosis and ferroptosis via the AMPK pathway in alcoholic fatty liver disease. You Y, et al. Free Radic Biol Med, 2022 Nov 20. PMID 36336231
  2. Identification of inducible genes at the early stage of adipocyte differentiation of 3T3-L1 cells. Imagawa M, et al. Biochem Biophys Res Commun, 1999 Jan 19. PMID 9918832
  3. FAD104, a regulatory factor of adipogenesis, acts as a novel regulator of calvarial bone formation. Kishimoto K, et al. J Biol Chem, 2013 Nov 1. PMID 24052261, Free PMC Article
  4. Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis. Garikipati VNS, et al. Nat Commun, 2019 Sep 20. PMID 31541092, Free PMC Article
  5. [Molecular Mechanisms of Early-stage Adipocyte Differentiation and Multi-functional Roles of Newly Isolated Adipogenic Factors]. Imagawa M. Yakugaku Zasshi, 2016. PMID 27040346

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FNDC3B protects steatosis and ferroptosis via the AMPK pathway in alcoholic fatty liver disease.
    Title: FNDC3B protects steatosis and ferroptosis via the AMPK pathway in alcoholic fatty liver disease.
  2. Findings highlight a physiological role for circRNAs in cardiac repair and indicate that modulation of circFndc3b expression may represent a potential strategy to promote cardiac function and remodeling after MI.
    Title: Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis.
  3. miR-215-5p is a negative regulator of adipocyte differentiation through post-transcriptional regulation of FNDC3B and CTNNBIP1 during early adipogenesis
    Title: MicroRNA-215 impairs adipocyte differentiation and co-represses FNDC3B and CTNNBIP1.
  4. fad104 suppressed anchorage-independent growth of melanoma cells, and the N-terminal region of FAD104 is essential for inhibiting malignant transformation and STAT3 activity
    Title: FAD104, a Regulator of Adipogenesis and Osteogenesis, Interacts with the C-Terminal Region of STAT3 and Represses Malignant Transformation of Melanoma Cells.
  5. It contribute not only to adipogenesis but also to other physiological events like pre-implantation in embryonic developments.
    Title: [Molecular Mechanisms of Early-stage Adipocyte Differentiation and Multi-functional Roles of Newly Isolated Adipogenic Factors].
  6. down-regulation of Smad1/5/8 phosphorylation by FAD104 is dependent on the N-terminal region of FAD104 and that fad104 functions as a novel negative regulator of BMP/Smad signaling and is required for proper development for calvarial bone.
    Title: FAD104, a regulatory factor of adipogenesis, acts as a novel regulator of calvarial bone formation.
  7. Indispensable role of factor for adipocyte differentiation 104 (fad104) in lung maturation
    Title: Indispensable role of factor for adipocyte differentiation 104 (fad104) in lung maturation.
  8. fad104 reciprocally regulates differentiation of adipocytes and osteoblast; functions as a positive regulator in adipocyte differentiation and as a negative regulator in osteoblast differentiation.
    Title: Fad104, a positive regulator of adipogenesis, negatively regulates osteoblast differentiation.
  9. Fad104 is essential for the survival of newborns just after birth and important for cell proliferation, adhesion, spreading and migration.
    Title: Disruption of the novel gene fad104 causes rapid postnatal death and attenuation of cell proliferation, adhesion, spreading and migration.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4164

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within fibroblast migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within type II pneumocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fibronectin type III domain-containing protein 3B
Names
HCV NS5A-binding protein 37
factor for adipocyte differentiation 104

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356953.1 → NP_001343882.1  fibronectin type III domain-containing protein 3B

    Status: VALIDATED

    Source sequence(s)
    AC116585, AC118696, AC140372, AK147346
    Consensus CDS
    CCDS17274.1
    UniProtKB/Swiss-Prot
    Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86
    UniProtKB/TrEMBL
    A0A0R4J0H8
    Related
    ENSMUSP00000141620.2, ENSMUST00000195008.6
    Conserved Domains (2) summary
    cd00063
    Location:691 → 765
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:878 → 950
    fn3; Fibronectin type III domain

  2. NM_173182.3 → NP_775274.2  fibronectin type III domain-containing protein 3B

    See identical proteins and their annotated locations for NP_775274.2

    Status: VALIDATED

    Source sequence(s)
    AC140372, AK220297, AW491305
    Consensus CDS
    CCDS17274.1
    UniProtKB/Swiss-Prot
    Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86
    UniProtKB/TrEMBL
    A0A0R4J0H8
    Related
    ENSMUSP00000041495.5, ENSMUST00000046157.10
    Conserved Domains (2) summary
    cd00063
    Location:691 → 765
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:878 → 950
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    27470284..27765469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535547.5 → XP_006535610.1  fibronectin type III domain-containing protein 3B isoform X4

    UniProtKB/Swiss-Prot
    Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86
    Conserved Domains (2) summary
    cd00063
    Location:575 → 690
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:803 → 875
    fn3; Fibronectin type III domain

  2. XM_006535541.5 → XP_006535604.1  fibronectin type III domain-containing protein 3B isoform X1

    See identical proteins and their annotated locations for XP_006535604.1

    UniProtKB/Swiss-Prot
    Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86
    UniProtKB/TrEMBL
    A0A0R4J0H8
    Conserved Domains (2) summary
    cd00063
    Location:691 → 765
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:878 → 950
    fn3; Fibronectin type III domain

  3. XM_036163344.1 → XP_036019237.1  fibronectin type III domain-containing protein 3B isoform X2

    UniProtKB/Swiss-Prot
    Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86
    Conserved Domains (2) summary
    cd00063
    Location:673 → 747
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:860 → 932
    fn3; Fibronectin type III domain

  4. XM_011249712.4 → XP_011248014.1  fibronectin type III domain-containing protein 3B isoform X1

    See identical proteins and their annotated locations for XP_011248014.1

    UniProtKB/Swiss-Prot
    Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86
    UniProtKB/TrEMBL
    A0A0R4J0H8
    Conserved Domains (2) summary
    cd00063
    Location:691 → 765
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:878 → 950
    fn3; Fibronectin type III domain

  5. XM_036163342.1 → XP_036019235.1  fibronectin type III domain-containing protein 3B isoform X1

    UniProtKB/Swiss-Prot
    Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86
    UniProtKB/TrEMBL
    A0A0R4J0H8
    Conserved Domains (2) summary
    cd00063
    Location:691 → 765
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:878 → 950
    fn3; Fibronectin type III domain

  6. XM_006535544.5 → XP_006535607.1  fibronectin type III domain-containing protein 3B isoform X1

    See identical proteins and their annotated locations for XP_006535607.1

    UniProtKB/Swiss-Prot
    Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86
    UniProtKB/TrEMBL
    A0A0R4J0H8
    Conserved Domains (2) summary
    cd00063
    Location:691 → 765
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:878 → 950
    fn3; Fibronectin type III domain

  7. XM_036163347.1 → XP_036019240.1  fibronectin type III domain-containing protein 3B isoform X5

    UniProtKB/Swiss-Prot
    Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86
    Conserved Domains (2) summary
    cd00063
    Location:557 → 672
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:785 → 857
    fn3; Fibronectin type III domain

  8. XM_036163345.1 → XP_036019238.1  fibronectin type III domain-containing protein 3B isoform X2

    UniProtKB/Swiss-Prot
    Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86
    Conserved Domains (2) summary
    cd00063
    Location:673 → 747
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:860 → 932
    fn3; Fibronectin type III domain

  9. XM_036163346.1 → XP_036019239.1  fibronectin type III domain-containing protein 3B isoform X4

    UniProtKB/Swiss-Prot
    Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86
    Conserved Domains (2) summary
    cd00063
    Location:575 → 690
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:803 → 875
    fn3; Fibronectin type III domain

  10. XM_030252836.2 → XP_030108696.1  fibronectin type III domain-containing protein 3B isoform X1

    UniProtKB/Swiss-Prot
    Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86
    UniProtKB/TrEMBL
    A0A0R4J0H8
    Conserved Domains (2) summary
    cd00063
    Location:691 → 765
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:878 → 950
    fn3; Fibronectin type III domain

  11. XM_017319738.3 → XP_017175227.1  fibronectin type III domain-containing protein 3B isoform X1

    UniProtKB/Swiss-Prot
    Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86
    UniProtKB/TrEMBL
    A0A0R4J0H8
    Conserved Domains (2) summary
    cd00063
    Location:691 → 765
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:878 → 950
    fn3; Fibronectin type III domain

  12. XM_036163341.1 → XP_036019234.1  fibronectin type III domain-containing protein 3B isoform X1

    UniProtKB/Swiss-Prot
    Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86
    UniProtKB/TrEMBL
    A0A0R4J0H8
    Conserved Domains (2) summary
    cd00063
    Location:691 → 765
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:878 → 950
    fn3; Fibronectin type III domain

  13. XM_011249711.3 → XP_011248013.1  fibronectin type III domain-containing protein 3B isoform X1

    See identical proteins and their annotated locations for XP_011248013.1

    UniProtKB/Swiss-Prot
    Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86
    UniProtKB/TrEMBL
    A0A0R4J0H8
    Conserved Domains (2) summary
    cd00063
    Location:691 → 765
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:878 → 950
    fn3; Fibronectin type III domain

  14. XM_036163343.1 → XP_036019236.1  fibronectin type III domain-containing protein 3B isoform X1

    UniProtKB/Swiss-Prot
    Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86
    UniProtKB/TrEMBL
    A0A0R4J0H8
    Conserved Domains (2) summary
    cd00063
    Location:691 → 765
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:878 → 950
    fn3; Fibronectin type III domain

  15. XM_006535546.4 → XP_006535609.1  fibronectin type III domain-containing protein 3B isoform X3

    UniProtKB/Swiss-Prot
    Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86
    Conserved Domains (2) summary
    cd00063
    Location:623 → 697
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:821 → 881
    fn3; Fibronectin type III domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NWW9.1 GenPept UniProtKB/Swiss-Prot:Q6NWW9

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