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Aifm2 apoptosis-inducing factor, mitochondrion-associated 2 [ Mus musculus (house mouse) ]

Gene ID: 71361, updated on 17-Aug-2024

Summary

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Official Symbol
Aifm2provided by MGI
Official Full Name
apoptosis-inducing factor, mitochondrion-associated 2provided by MGI
Primary source
MGI:MGI:1918611
See related
Ensembl:ENSMUSG00000020085 AllianceGenome:MGI:1918611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Amid; FSP1; PRG3; 5430437E11Rik; D730001I10Rik
Summary
Predicted to enable several functions, including electron-transferring-flavoprotein dehydrogenase activity; flavin adenine dinucleotide binding activity; and oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor. Involved in regulation of cellular response to oxidative stress. Located in mitochondrial membrane and nucleus. Is expressed in adrenal medulla; central nervous system; and retina. Orthologous to human AIFM2 (apoptosis inducing factor mitochondria associated 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 65.8), bladder adult (RPKM 44.5) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Aifm2 in Genome Data Viewer
Location:
10 B4; 10 32.27 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (61551042..61575474)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (61715263..61739260)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9032 Neighboring gene secretion associated Ras related GTPase 1A Neighboring gene STARR-positive B cell enhancer ABC_E1800 Neighboring gene trypsin domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_26853 Neighboring gene macroH2A.2 histone Neighboring gene STARR-seq mESC enhancer starr_26854 Neighboring gene microRNA 5108 Neighboring gene predicted gene 2137

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Aifm2, a NADH Oxidase, Supports Robust Glycolysis and Is Required for Cold- and Diet-Induced Thermogenesis. Nguyen HP, et al. Mol Cell, 2020 Feb 6. PMID 31952989, Free PMC Article
  2. A brain-specific isoform of apoptosis-inducing factor 2 attenuates ischemia-induced oxidative stress in HT22 cells. Xie Y, et al. Neurochem Int, 2018 Jan. PMID 28732772
  3. Apoptosis-inducing Factor, Mitochondrion-associated 2, Regulates Klf1 in a Mouse Erythroleukemia Cell Line. Kojima N, et al. Anticancer Res, 2015 Aug. PMID 26168492
  4. The p53-inducible apoptotic protein AMID is not required for normal development and tumor suppression. Mei J, et al. Oncogene, 2006 Feb 9. PMID 16186796
  5. Targeted disruption of the mouse ing1 locus results in reduced body size, hypersensitivity to radiation and elevated incidence of lymphomas. Kichina JV, et al. Oncogene, 2006 Feb 9. PMID 16170338

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ferroptosis of macrophages facilitates bone loss in apical periodontitis via NRF2/FSP1/ROS pathway.
    Title: Ferroptosis of macrophages facilitates bone loss in apical periodontitis via NRF2/FSP1/ROS pathway.
  2. Metabolomic profiling identifies a novel mechanism for heat strokerelated acute kidney injury.
    Title: Metabolomic profiling identifies a novel mechanism for heat stroke‑related acute kidney injury.
  3. the brain-specific isoform of AIF, AIF-2, constitutively expressed in mouse hippocampal HT22 cell lines, where it exerts protective effects against oxygen and glucose deprivation-induced mitochondrial dysfunction, oxidative stress and apoptosis through inhibiting the nuclear translocation of AIF-1.
    Title: A brain-specific isoform of apoptosis-inducing factor 2 attenuates ischemia-induced oxidative stress in HT22 cells.
  4. 4-hydroxy-2-nonenal adduction of AIFm2 shifts the function of AIFm2 from an NADH oxidoreductase to a proapototic protein.
    Title: Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling.
  5. Aifm2 may function in differentiation of erythroid murine erythroleukemia line cells in vitro.
    Title: Apoptosis-inducing Factor, Mitochondrion-associated 2, Regulates Klf1 in a Mouse Erythroleukemia Cell Line.
  6. Results demonstrate nuclear AIF translocation only in PARG-null TS cells, which demonstrates the presence of AIF-mediated cell death.
    Title: Activation of cell death mediated by apoptosis-inducing factor due to the absence of poly(ADP-ribose) glycohydrolase.
  7. AMID is not required for normal development and p53-mediated tumor suppression.
    Title: The p53-inducible apoptotic protein AMID is not required for normal development and tumor suppression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables electron-transferring-flavoprotein dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables electron-transferring-flavoprotein dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic mitochondrial changes IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within apoptotic mitochondrial changes ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular detoxification ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ferroptosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquinone metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in vitamin K metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ferroptosis suppressor protein 1
Names
apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death
apoptosis-inducing factor 2
apoptosis-inducing factor homologous mitochondrion-associated inducer of death
apoptosis-inducing factor-like mitchondrion-associated inducer of death
apoptosis-inducing factor-like mitochondrion-associated inducer of death
p53-responsive gene 3 protein
NP_001034283.1
NP_001271229.1
NP_722474.2
NP_835159.1
XP_006514184.1
XP_006514185.1
XP_006514187.1
XP_006514188.1
XP_006514189.1
XP_006514190.1
XP_011241874.1
XP_011241875.1
XP_036011907.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039194.3 → NP_001034283.1  ferroptosis suppressor protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001034283.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an additional segment in the 3' UTR region, compared to variant 4. Variants 2, 3 and 4 encode the same isoform 2.
    Source sequence(s)
    AC153136, AK147741, BB847470
    Consensus CDS
    CCDS23884.1
    UniProtKB/Swiss-Prot
    Q8BUE4, Q8CHZ2
    Related
    ENSMUSP00000097297.3, ENSMUST00000099706.9
    Conserved Domains (1) summary
    cl39093
    Location:39 → 356
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

  2. NM_001284300.1 → NP_001271229.1  ferroptosis suppressor protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001271229.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the shorter isoform (2). Variants 2, 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AK017403, BB847470, BC038129
    Consensus CDS
    CCDS23884.1
    UniProtKB/Swiss-Prot
    Q8BUE4, Q8CHZ2
    Related
    ENSMUSP00000101095.3, ENSMUST00000105455.9
    Conserved Domains (1) summary
    cl39093
    Location:39 → 356
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

  3. NM_153779.2 → NP_722474.2  ferroptosis suppressor protein 1 isoform 1

    See identical proteins and their annotated locations for NP_722474.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) has an alternate 5' UTR exon and lacks the penultimate exon, resulting in a downstream stop codon, compared to variant 4. The resulting isoform (1) is longer and has a distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AK017403, BC038129
    Consensus CDS
    CCDS48576.1
    UniProtKB/Swiss-Prot
    Q8BUE4
    Related
    ENSMUSP00000078998.6, ENSMUST00000080099.6
    Conserved Domains (2) summary
    pfam07992
    Location:20 → 302
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    cl21457
    Location:268 → 364
    TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...

  4. NM_178058.4 → NP_835159.1  ferroptosis suppressor protein 1 isoform 2

    See identical proteins and their annotated locations for NP_835159.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 3' UTR exon, compared to variant 4. Variants 2, 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AC153136, AK085656, BB847470
    Consensus CDS
    CCDS23884.1
    UniProtKB/Swiss-Prot
    Q8BUE4, Q8CHZ2
    Related
    ENSMUSP00000070054.5, ENSMUST00000067857.11
    Conserved Domains (1) summary
    cl39093
    Location:39 → 356
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    61551042..61575474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156014.1 → XP_036011907.1  ferroptosis suppressor protein 1 isoform X1

    Conserved Domains (1) summary
    cl39093
    Location:39 → 357
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

  2. XM_011243572.2 → XP_011241874.1  ferroptosis suppressor protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011241874.1

    Conserved Domains (1) summary
    cl39093
    Location:39 → 357
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

  3. XM_006514121.4 → XP_006514184.1  ferroptosis suppressor protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006514184.1

    Conserved Domains (1) summary
    cl39093
    Location:39 → 357
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

  4. XM_006514122.5 → XP_006514185.1  ferroptosis suppressor protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006514185.1

    Conserved Domains (1) summary
    cl39093
    Location:39 → 357
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

  5. XM_006514124.5 → XP_006514187.1  ferroptosis suppressor protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006514187.1

    UniProtKB/Swiss-Prot
    Q8BUE4, Q8CHZ2
    Conserved Domains (1) summary
    cl39093
    Location:39 → 356
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

  6. XM_006514125.2 → XP_006514188.1  ferroptosis suppressor protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006514188.1

    Conserved Domains (1) summary
    cl39093
    Location:2 → 267
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

  7. XM_006514126.4 → XP_006514189.1  ferroptosis suppressor protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006514189.1

    Conserved Domains (1) summary
    cl39093
    Location:2 → 267
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

  8. XM_006514127.5 → XP_006514190.1  ferroptosis suppressor protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006514190.1

    Conserved Domains (1) summary
    cl39093
    Location:2 → 267
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

  9. XM_011243573.3 → XP_011241875.1  ferroptosis suppressor protein 1 isoform X4

    Conserved Domains (1) summary
    cl39093
    Location:26 → 178
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

RNA

  1. XR_004936276.1 RNA Sequence

  2. XR_004936277.1 RNA Sequence

  3. XR_380441.4 RNA Sequence

  4. XR_003948803.2 RNA Sequence

  5. XR_004936278.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BUE4.1 GenPept UniProtKB/Swiss-Prot:Q8BUE4

Gene LinkOut

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