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Rbks ribokinase [ Mus musculus (house mouse) ]

Gene ID: 71336, updated on 2-Nov-2024

Summary

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Official Symbol
Rbksprovided by MGI
Official Full Name
ribokinaseprovided by MGI
Primary source
MGI:MGI:1918586
See related
Ensembl:ENSMUSG00000029136 AllianceGenome:MGI:1918586
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RK; RBSK; 5230400M11Rik
Summary
Enables ribokinase activity. Involved in pentose-phosphate shunt. Predicted to be located in nucleus. Predicted to be active in cytosol. Is expressed in cerebral cortex; heart; and liver. Orthologous to human RBKS (ribokinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in large intestine adult (RPKM 4.4), testis adult (RPKM 4.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rbks in Genome Data Viewer
Location:
5 B1; 5 17.27 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31781783..31855042, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (31624439..31697649, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene expressed sequence AI839979 Neighboring gene STARR-seq mESC enhancer starr_12777 Neighboring gene STARR-positive B cell enhancer ABC_E4750 Neighboring gene STARR-seq mESC enhancer starr_12780 Neighboring gene STARR-seq mESC enhancer starr_12781 Neighboring gene predicted gene, 38424 Neighboring gene mitochondrial ribosomal protein L33 Neighboring gene microRNA 3473e Neighboring gene STARR-positive B cell enhancer ABC_E11723 Neighboring gene BRISC and BRCA1 A complex member 2 Neighboring gene STARR-seq mESC enhancer starr_12782 Neighboring gene STARR-seq mESC enhancer starr_12783 Neighboring gene STARR-seq mESC enhancer starr_12784 Neighboring gene STARR-positive B cell enhancer mm9_chr5:32316174-32316475 Neighboring gene predicted gene, 52770 Neighboring gene STARR-seq mESC enhancer starr_12785 Neighboring gene microRNA 12198 Neighboring gene predicted gene, 40277

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ribose Accelerates Gut Motility and Suppresses Mouse Body Weight Gaining. Liu Y, et al. Int J Biol Sci, 2016. PMID 27194947, Free PMC Article
  2. Delineating biological pathways unique to embryonic stem cell-derived insulin-producing cell lines from their noninsulin-producing progenitor cell lines. Chen TS, et al. Endocrinology, 2010 Aug. PMID 20501672
  3. Glycogen formation via the pentose phosphate pathway in mice in vivo. HIATT HH. J Biol Chem, 1957 Feb. PMID 13405914
  4. Exploring the transcriptome of ciliated cells using in silico dissection of human tissues. Ivliev AE, et al. PLoS One, 2012. PMID 22558177, Free PMC Article
  5. Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. Bowman CE, et al. Mol Cell Biol, 2016 Aug 1. PMID 27215380, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ribokinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in D-ribose catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribokinase
NP_001404658.1
NP_001404659.1
NP_001404660.1
NP_694876.1
XP_006504176.1
XP_011239073.1
XP_036021384.1
XP_036021385.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417729.1 → NP_001404658.1  ribokinase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC114613

  2. NM_001417730.1 → NP_001404659.1  ribokinase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC114613

  3. NM_001417731.1 → NP_001404660.1  ribokinase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC114613

  4. NM_153196.2 → NP_694876.1  ribokinase isoform 1

    See identical proteins and their annotated locations for NP_694876.1

    Status: VALIDATED

    Source sequence(s)
    AC114613
    Consensus CDS
    CCDS19187.1
    UniProtKB/Swiss-Prot
    Q8R1Q9
    Related
    ENSMUSP00000031018.8, ENSMUST00000031018.10
    Conserved Domains (1) summary
    TIGR02152
    Location:23 → 319
    D_ribokin_bact; ribokinase

RNA

  1. NR_184568.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC114613

  2. NR_184569.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC114613

  3. NR_184570.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC114613

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    31781783..31855042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165492.1 → XP_036021385.1  ribokinase isoform X4

    Conserved Domains (1) summary
    cl00192
    Location:1 → 170
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...

  2. XM_036165491.1 → XP_036021384.1  ribokinase isoform X4

    Conserved Domains (1) summary
    cl00192
    Location:1 → 170
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...

  3. XM_006504113.5 → XP_006504176.1  ribokinase isoform X2

    Conserved Domains (1) summary
    cl00192
    Location:23 → 266
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...

  4. XM_011240771.4 → XP_011239073.1  ribokinase isoform X1

    Conserved Domains (1) summary
    cl00192
    Location:23 → 266
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1Q9.1 GenPept UniProtKB/Swiss-Prot:Q8R1Q9

Gene LinkOut

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