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Tln2 talin 2 [ Mus musculus (house mouse) ]

Gene ID: 70549, updated on 2-Nov-2024

Summary

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Official Symbol
Tln2provided by MGI
Official Full Name
talin 2provided by MGI
Primary source
MGI:MGI:1917799
See related
Ensembl:ENSMUSG00000052698 AllianceGenome:MGI:1917799
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0320; 5730421P04Rik
Summary
Predicted to enable integrin binding activity. Predicted to be involved in cell-cell adhesion and presynaptic actin cytoskeleton organization. Located in fascia adherens and synapse. Is expressed in several structures, including brain; ganglia; heart; submandibular gland; and trigeminal nerve. Orthologous to human TLN2 (talin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in kidney adult (RPKM 19.0), testis adult (RPKM 15.4) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Tln2 in Genome Data Viewer
Location:
9 C; 9 36.39 cM
Exon count:
67
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (67124371..67541357, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (67217085..67634045, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24488 Neighboring gene predicted gene 10646 Neighboring gene predicted gene, 22145 Neighboring gene STARR-seq mESC enhancer starr_24489 Neighboring gene predicted gene, 19299 Neighboring gene predicted gene, 40529 Neighboring gene STARR-seq mESC enhancer starr_24490 Neighboring gene STARR-seq mESC enhancer starr_24492 Neighboring gene microRNA 190a Neighboring gene STARR-seq mESC enhancer starr_24494 Neighboring gene STARR-seq mESC enhancer starr_24495 Neighboring gene STARR-seq mESC enhancer starr_24496 Neighboring gene STARR-seq mESC enhancer starr_24498 Neighboring gene predicted gene, 30936 Neighboring gene C2 calcium-dependent domain containing 4B Neighboring gene microRNA 7241

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The N-terminal half of talin2 is sufficient for mouse development and survival. Chen NT, et al. Biochem Biophys Res Commun, 2005 Nov 18. PMID 16202389
  2. Loss of talin in cardiac fibroblasts results in augmented ventricular cardiomyocyte hypertrophy in response to pressure overload. Noll NA, et al. Am J Physiol Heart Circ Physiol, 2022 May 1. PMID 35333120, Free PMC Article
  3. Talin 2 is a large and complex gene encoding multiple transcripts and protein isoforms. Debrand E, et al. FEBS J, 2009 Mar. PMID 19220457, Free PMC Article
  4. Talin-2 regulates integrin functions in exosomes. Soe ZY, et al. Biochem Biophys Res Commun, 2019 May 7. PMID 30879762
  5. Talin2 binds to non-muscle myosin IIa and regulates cell attachment and fibronectin secretion. Wang X, et al. Sci Rep, 2024 Aug 30. PMID 39215026, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Talin2 binds to non-muscle myosin IIa and regulates cell attachment and fibronectin secretion.
    Title: Talin2 binds to non-muscle myosin IIa and regulates cell attachment and fibronectin secretion.
  2. Loss of talin in cardiac fibroblasts results in augmented ventricular cardiomyocyte hypertrophy in response to pressure overload.
    Title: Loss of talin in cardiac fibroblasts results in augmented ventricular cardiomyocyte hypertrophy in response to pressure overload.
  3. Talin-2-deficient T-cell exosomes were less efficiently internalized by endothelial cells, compared with control exosomes.
    Title: Talin-2 regulates integrin functions in exosomes.
  4. talin unfolding determines DLC1 downstream signalling and, consequently, cell mechanics.
    Title: Mechanotransduction in talin through the interaction of the R8 domain with DLC1.
  5. Loss of all Tln forms from the heart-muscle cell leads to myocyte instability and a dilated cardiomyopathy.
    Title: Loss of mouse cardiomyocyte talin-1 and talin-2 leads to β-1 integrin reduction, costameric instability, and dilated cardiomyopathy.
  6. Binding of vinculin to the R1-R3 region of the talin rod is important for focal adhesion stability.
    Title: Vinculin controls talin engagement with the actomyosin machinery.
  7. Data indicate that talin mechanics are isoform specific so that expression of either talin-1 or talin-2 modulates extracellular rigidity sensing.
    Title: Extracellular rigidity sensing by talin isoform-specific mechanical linkages.
  8. Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload.
    Title: Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload.
  9. Tln2(cd/cd) mice showed no major difference in body mass or the weight of the major organs compared to wild-type, although they displayed a mildly dystrophic phenotype.
    Title: Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile.
  10. Talin1 was concentrated in peripheral focal adhesions while talin2 was observed in both focal and fibrillar adhesions, and knock-down of talin2 compromised fibronectin fibrillogenesis
    Title: New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC100340

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in presynaptic actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in fascia adherens IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
talin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081242.3 → NP_001074711.2  talin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC107740, AC173343, CT573422
    Consensus CDS
    CCDS52849.1
    UniProtKB/TrEMBL
    B2RY15, E9PUM4
    Related
    ENSMUSP00000039633.8, ENSMUST00000040025.14
    Conserved Domains (10) summary
    cd12150
    Location:1656 → 1827
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:90 → 316
    B41; Band 4.1 homologues
    smart00307
    Location:2337 → 2532
    ILWEQ; I/LWEQ domain
    cd10569
    Location:312 → 403
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam00373
    Location:206 → 316
    FERM_M; FERM central domain
    pfam08913
    Location:1850 → 1974
    VBS; Vinculin Binding Site
    pfam09141
    Location:494 → 655
    Talin_middle; Talin, middle domain
    pfam09379
    Location:92 → 188
    FERM_N; FERM N-terminal domain
    pfam16511
    Location:4 → 85
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl19756
    Location:706 → 832
    I_LWEQ; I/LWEQ domain

  2. NM_001408298.1 → NP_001395227.1  talin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC107740, AC173343, CT573422

  3. NM_001408299.1 → NP_001395228.1  talin-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC107740

  4. NM_001408300.1 → NP_001395229.1  talin-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC107740

  5. NM_001408301.1 → NP_001395230.1  talin-2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC107740

  6. NM_027458.2 → NP_081734.1  talin-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC107740
    UniProtKB/TrEMBL
    A0A1L1SRI1, Q8CDM9
    Related
    ENSMUSP00000149284.2, ENSMUST00000215267.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    67124371..67541357 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511434.5 → XP_006511497.1  talin-2 isoform X1

    See identical proteins and their annotated locations for XP_006511497.1

    UniProtKB/TrEMBL
    B2RY15
    Conserved Domains (9) summary
    cd12150
    Location:1658 → 1829
    talin-RS; rod-segment of the talin C-terminal domain
    smart00307
    Location:2339 → 2549
    ILWEQ; I/LWEQ domain
    cd10569
    Location:314 → 405
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam08913
    Location:1852 → 1976
    VBS; Vinculin Binding Site
    cd17172
    Location:6 → 89
    FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
    cd17174
    Location:90 → 201
    FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
    pfam00373
    Location:211 → 318
    FERM_M; FERM central domain
    pfam09141
    Location:496 → 657
    Talin_middle; Talin, middle domain
    cl19756
    Location:691 → 767
    I_LWEQ; I/LWEQ domain

  2. XM_011242812.4 → XP_011241114.1  talin-2 isoform X3

    UniProtKB/TrEMBL
    B2RY15
    Conserved Domains (9) summary
    cd12150
    Location:1658 → 1829
    talin-RS; rod-segment of the talin C-terminal domain
    smart00307
    Location:2299 → 2509
    ILWEQ; I/LWEQ domain
    cd10569
    Location:314 → 405
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam08913
    Location:1852 → 1936
    VBS; Vinculin Binding Site
    cd17172
    Location:6 → 89
    FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
    cd17174
    Location:90 → 201
    FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
    pfam00373
    Location:211 → 318
    FERM_M; FERM central domain
    pfam09141
    Location:496 → 657
    Talin_middle; Talin, middle domain
    cl19756
    Location:691 → 767
    I_LWEQ; I/LWEQ domain

  3. XM_036155280.1 → XP_036011173.1  talin-2 isoform X2

    UniProtKB/TrEMBL
    A0A1L1SQ51, B2RY15
    Related
    ENSMUSP00000148901.2, ENSMUST00000215784.2
    Conserved Domains (9) summary
    cd12150
    Location:1658 → 1829
    talin-RS; rod-segment of the talin C-terminal domain
    smart00307
    Location:2339 → 2534
    ILWEQ; I/LWEQ domain
    cd10569
    Location:314 → 405
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam08913
    Location:1852 → 1976
    VBS; Vinculin Binding Site
    cd17172
    Location:6 → 89
    FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
    cd17174
    Location:90 → 201
    FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
    pfam00373
    Location:211 → 318
    FERM_M; FERM central domain
    pfam09141
    Location:496 → 657
    Talin_middle; Talin, middle domain
    cl19756
    Location:691 → 767
    I_LWEQ; I/LWEQ domain

  4. XM_036155278.1 → XP_036011171.1  talin-2 isoform X1

    UniProtKB/TrEMBL
    B2RY15
    Conserved Domains (9) summary
    cd12150
    Location:1658 → 1829
    talin-RS; rod-segment of the talin C-terminal domain
    smart00307
    Location:2339 → 2549
    ILWEQ; I/LWEQ domain
    cd10569
    Location:314 → 405
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam08913
    Location:1852 → 1976
    VBS; Vinculin Binding Site
    cd17172
    Location:6 → 89
    FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
    cd17174
    Location:90 → 201
    FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
    pfam00373
    Location:211 → 318
    FERM_M; FERM central domain
    pfam09141
    Location:496 → 657
    Talin_middle; Talin, middle domain
    cl19756
    Location:691 → 767
    I_LWEQ; I/LWEQ domain

  5. XM_006511433.3 → XP_006511496.1  talin-2 isoform X1

    See identical proteins and their annotated locations for XP_006511496.1

    UniProtKB/TrEMBL
    B2RY15
    Conserved Domains (9) summary
    cd12150
    Location:1658 → 1829
    talin-RS; rod-segment of the talin C-terminal domain
    smart00307
    Location:2339 → 2549
    ILWEQ; I/LWEQ domain
    cd10569
    Location:314 → 405
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam08913
    Location:1852 → 1976
    VBS; Vinculin Binding Site
    cd17172
    Location:6 → 89
    FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
    cd17174
    Location:90 → 201
    FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
    pfam00373
    Location:211 → 318
    FERM_M; FERM central domain
    pfam09141
    Location:496 → 657
    Talin_middle; Talin, middle domain
    cl19756
    Location:691 → 767
    I_LWEQ; I/LWEQ domain

  6. XM_036155279.1 → XP_036011172.1  talin-2 isoform X1

    UniProtKB/TrEMBL
    B2RY15
    Conserved Domains (9) summary
    cd12150
    Location:1658 → 1829
    talin-RS; rod-segment of the talin C-terminal domain
    smart00307
    Location:2339 → 2549
    ILWEQ; I/LWEQ domain
    cd10569
    Location:314 → 405
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam08913
    Location:1852 → 1976
    VBS; Vinculin Binding Site
    cd17172
    Location:6 → 89
    FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
    cd17174
    Location:90 → 201
    FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
    pfam00373
    Location:211 → 318
    FERM_M; FERM central domain
    pfam09141
    Location:496 → 657
    Talin_middle; Talin, middle domain
    cl19756
    Location:691 → 767
    I_LWEQ; I/LWEQ domain

  7. XM_011242811.3 → XP_011241113.1  talin-2 isoform X1

    See identical proteins and their annotated locations for XP_011241113.1

    UniProtKB/TrEMBL
    B2RY15
    Conserved Domains (9) summary
    cd12150
    Location:1658 → 1829
    talin-RS; rod-segment of the talin C-terminal domain
    smart00307
    Location:2339 → 2549
    ILWEQ; I/LWEQ domain
    cd10569
    Location:314 → 405
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam08913
    Location:1852 → 1976
    VBS; Vinculin Binding Site
    cd17172
    Location:6 → 89
    FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
    cd17174
    Location:90 → 201
    FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
    pfam00373
    Location:211 → 318
    FERM_M; FERM central domain
    pfam09141
    Location:496 → 657
    Talin_middle; Talin, middle domain
    cl19756
    Location:691 → 767
    I_LWEQ; I/LWEQ domain

  8. XM_030244583.1 → XP_030100443.1  talin-2 isoform X1

    UniProtKB/TrEMBL
    B2RY15
    Conserved Domains (9) summary
    cd12150
    Location:1658 → 1829
    talin-RS; rod-segment of the talin C-terminal domain
    smart00307
    Location:2339 → 2549
    ILWEQ; I/LWEQ domain
    cd10569
    Location:314 → 405
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam08913
    Location:1852 → 1976
    VBS; Vinculin Binding Site
    cd17172
    Location:6 → 89
    FERM_F0_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-2 (TLN2)
    cd17174
    Location:90 → 201
    FERM_F1_TLN2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-2 (TLN2)
    pfam00373
    Location:211 → 318
    FERM_M; FERM central domain
    pfam09141
    Location:496 → 657
    Talin_middle; Talin, middle domain
    cl19756
    Location:691 → 767
    I_LWEQ; I/LWEQ domain

  9. XM_006511441.3 → XP_006511504.1  talin-2 isoform X5

    UniProtKB/TrEMBL
    A0A1L1SRI1
    Related
    ENSMUSP00000149474.2, ENSMUST00000217550.2
    Conserved Domains (3) summary
    cd12150
    Location:504 → 675
    talin-RS; rod-segment of the talin C-terminal domain
    pfam08913
    Location:698 → 822
    VBS; Vinculin Binding Site
    cl19756
    Location:1185 → 1395
    I_LWEQ; I/LWEQ domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q71LX4.3 GenPept UniProtKB/Swiss-Prot:Q71LX4

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