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Gtf3c5 general transcription factor IIIC, polypeptide 5 [ Mus musculus (house mouse) ]

Gene ID: 70239, updated on 2-Nov-2024

Summary

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Official Symbol
Gtf3c5provided by MGI
Official Full Name
general transcription factor IIIC, polypeptide 5provided by MGI
Primary source
MGI:MGI:1917489
See related
Ensembl:ENSMUSG00000026816 AllianceGenome:MGI:1917489
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TFIIIC63; TFiiiC2-63; 2700084A09Rik
Summary
Predicted to enable DNA binding activity and RNA polymerase III general transcription initiation factor activity. Predicted to contribute to RNA polymerase III type 1 promoter sequence-specific DNA binding activity and RNA polymerase III type 2 promoter sequence-specific DNA binding activity. Acts upstream of or within skeletal muscle cell differentiation. Predicted to be located in nucleoplasm. Predicted to be part of transcription factor TFIIIC complex. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human GTF3C5 (general transcription factor IIIC subunit 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 12.0), limb E14.5 (RPKM 10.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Gtf3c5 in Genome Data Viewer
Location:
2 A3; 2 19.38 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (28456257..28473291, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (28566245..28583279, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10087 Neighboring gene ral guanine nucleotide dissociation stimulator Neighboring gene VISTA enhancer mm337 Neighboring gene carboxyl ester lipase Neighboring gene STARR-positive B cell enhancer mm9_chr2:28440723-28441024 Neighboring gene predicted gene, 22675 Neighboring gene STARR-seq mESC enhancer starr_04029 Neighboring gene STARR-positive B cell enhancer ABC_E2606 Neighboring gene growth factor independent 1B Neighboring gene predicted gene, 52548

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Rajan S, et al. Physiol Genomics, 2012 Feb 1. PMID 22147266
  2. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
  3. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article
  4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase III general transcription initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to RNA polymerase III type 1 promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase III type 2 promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription initiation at RNA polymerase III promoter IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIIC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIIC complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIIC complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
general transcription factor 3C polypeptide 5
Names
TF3C-epsilon
TFIIIC 63 kDa subunit
TFIIICepsilon
general transcription factor III polypeptide 5
transcription factor IIIC 63 kDa subunit
transcription factor IIIC subunit epsilon

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290484.1 → NP_001277413.1  general transcription factor 3C polypeptide 5 isoform a

    See identical proteins and their annotated locations for NP_001277413.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK147014, AL928994, AU016996, BQ179286
    Consensus CDS
    CCDS71012.1
    UniProtKB/Swiss-Prot
    Q8BLE3, Q8R0D0, Q8R2T8
    Related
    ENSMUSP00000109521.3, ENSMUST00000113889.9
    Conserved Domains (1) summary
    pfam09734
    Location:24 → 322
    Tau95; RNA polymerase III transcription factor (TF)IIIC subunit

  2. NM_148928.3 → NP_683730.1  general transcription factor 3C polypeptide 5 isoform b

    See identical proteins and their annotated locations for NP_683730.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AK147014, AU016996, BQ179286
    Consensus CDS
    CCDS15842.1
    UniProtKB/TrEMBL
    Q3UI98
    Related
    ENSMUSP00000028157.9, ENSMUST00000028157.9
    Conserved Domains (1) summary
    pfam09734
    Location:24 → 322
    Tau95; RNA polymerase III transcription factor (TF)IIIC subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    28456257..28473291 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162560.1 → XP_036018453.1  general transcription factor 3C polypeptide 5 isoform X2

    Conserved Domains (1) summary
    pfam09734
    Location:43 → 197
    Tau95; RNA polymerase III transcription factor (TF)IIIC subunit

  2. XM_011239177.4 → XP_011237479.1  general transcription factor 3C polypeptide 5 isoform X1

    Conserved Domains (1) summary
    pfam09734
    Location:43 → 197
    Tau95; RNA polymerase III transcription factor (TF)IIIC subunit
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R2T8.2 GenPept UniProtKB/Swiss-Prot:Q8R2T8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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