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Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 [ Mus musculus (house mouse) ]

Gene ID: 69568, updated on 14-Nov-2024

Summary

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Official Symbol
Vkorc1l1provided by MGI
Official Full Name
vitamin K epoxide reductase complex, subunit 1-like 1provided by MGI
Primary source
MGI:MGI:1916818
See related
Ensembl:ENSMUSG00000066735 AllianceGenome:MGI:1916818
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310024K08Rik
Summary
Enables vitamin-K-epoxide reductase (warfarin-sensitive) activity. Involved in vitamin K metabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in liver. Orthologous to human VKORC1L1 (vitamin K epoxide reductase complex subunit 1 like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 7.6), CNS E18 (RPKM 7.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Vkorc1l1 in Genome Data Viewer
Location:
5 G1.3; 5 68.26 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (129970950..130015533)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (129942109..129986692)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2766 Neighboring gene zinc finger BED-type containing 5 Neighboring gene STARR-seq mESC enhancer starr_14464 Neighboring gene nuclear protein transcriptional regulator 2 Neighboring gene STARR-positive B cell enhancer ABC_E1308 Neighboring gene STARR-seq mESC enhancer starr_14467 Neighboring gene STARR-seq mESC enhancer starr_14468 Neighboring gene glucuronidase, beta Neighboring gene STARR-positive B cell enhancer ABC_E10355 Neighboring gene argininosuccinate lyase Neighboring gene predicted gene, 40334

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of VKORC1L1 is critical for p53-mediated tumor suppression through vitamin K metabolism.
    Title: Regulation of VKORC1L1 is critical for p53-mediated tumor suppression through vitamin K metabolism.
  2. VKORC1L1 supports vitamin K-dependent (VKD) protein protein carboxylation in vivo.
    Title: VKOR paralog VKORC1L1 supports vitamin K-dependent protein carboxylation in vivo.
  3. Vkorc1l1 promotes adipogenesis and possibly obesity. Downregulation of Vkorc1l1 increases intracellular vitamin K2 level and impedes preadipocyte differentiation.
    Title: The Vitamin K Epoxide Reductase Vkorc1l1 Promotes Preadipocyte Differentiation in Mice.
  4. quantified mRNA levels for VKORC1, VKORC1L1, GGCX, and NQO1 and measured VKOR enzymatic activities in 29 different tissues
    Title: Two enzymes catalyze vitamin K 2,3-epoxide reductase activity in mouse: VKORC1 is highly expressed in exocrine tissues while VKORC1L1 is highly expressed in brain.
  5. The involvement of VKORC1L1 in VKOR activity partly explains the low susceptibility of some extrahepatic tissues to vitamin K antagonists.
    Title: VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy.
  6. molecular cloning
    Title: Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables quinone binding IEA
Inferred from Electronic Annotation
more info
  
enables vitamin-K-epoxide reductase (warfarin-sensitive) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables vitamin-K-epoxide reductase (warfarin-sensitive) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables vitamin-K-epoxide reductase (warfarin-sensitive) activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables vitamin-K-epoxide reductase (warfarin-sensitive) activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peptidyl-glutamic acid carboxylation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-glutamic acid carboxylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in vitamin K metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vitamin K metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vitamin K metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within vitamin K metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in vitamin K metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
vitamin K epoxide reductase complex subunit 1-like protein 1
Names
VKORC1-like protein 1
NP_001001327.1
NP_001273311.1
NP_081397.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001327.2 → NP_001001327.1  vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001001327.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK033702, AK078942, BC085133, BE954096, CF533903, CK639505, CN457470
    Consensus CDS
    CCDS19704.1
    UniProtKB/TrEMBL
    Q0VGU5
    Related
    ENSMUSP00000144608.2, ENSMUST00000201855.2
    Conserved Domains (1) summary
    cl01729
    Location:18 → 65
    VKOR; Vitamin K epoxide reductase (VKOR) family

  2. NM_001286382.1 → NP_001273311.1  vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AK033702, AK078942, BC085133, BE954096, CF533903, CK639505, CN457470, CN701203
    Consensus CDS
    CCDS80417.1
    UniProtKB/TrEMBL
    A0A0M3HEP8, Q9D781
    Related
    ENSMUSP00000073601.6, ENSMUST00000073945.6
    Conserved Domains (1) summary
    cd12917
    Location:19 → 110
    VKOR_euk; Vitamin K epoxide reductase family in eukaryotes, excluding plants

  3. NM_027121.4 → NP_081397.1  vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_081397.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK033702, AK078942, BC085133, BE954096, CF533903, CK639505, CN457470, CN701203
    Consensus CDS
    CCDS19703.1
    UniProtKB/Swiss-Prot
    Q05AD4, Q6TEK5
    Related
    ENSMUSP00000059139.9, ENSMUST00000051758.11
    Conserved Domains (1) summary
    cd12917
    Location:18 → 156
    VKOR_euk; Vitamin K epoxide reductase family in eukaryotes, excluding plants

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    129970950..130015533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6TEK5.1 GenPept UniProtKB/Swiss-Prot:Q6TEK5

Gene LinkOut

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