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foxn3 forkhead box N3 [ Danio rerio (zebrafish) ]

Gene ID: 692291, updated on 2-Nov-2024

Summary

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Official Symbol
foxn3provided by ZNC
Official Full Name
forkhead box N3provided by ZNC
Primary source
ZFIN:ZDB-GENE-060512-39
See related
Ensembl:ENSDARG00000012833 AllianceGenome:ZFIN:ZDB-GENE-060512-39
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:136571
Summary
Predicted to enable DNA-binding transcription factor activity and cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in female organism and male organism. Orthologous to human FOXN3 (forkhead box N3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See foxn3 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (16565185..16741175)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (16556384..16726538)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene transfer RNA lysine (anticodon UUU) Neighboring gene EF-hand calcium binding domain 11 Neighboring gene uncharacterized LOC137488083 Neighboring gene stonin 2 Neighboring gene iodothyronine deiodinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose. Karanth S, et al. Cell Rep, 2018 Jul 10. PMID 29996093, Free PMC Article
  2. FOXN3 Regulates Hepatic Glucose Utilization. Karanth S, et al. Cell Rep, 2016 Jun 21. PMID 27292639, Free PMC Article
  3. Multiple thyrotropin β-subunit and thyrotropin receptor-related genes arose during vertebrate evolution. Maugars G, et al. PLoS One, 2014. PMID 25386660, Free PMC Article
  4. Time point-based integrative analyses of deep-transcriptome identify four signal pathways in blastemal regeneration of zebrafish lower jaw. Zhang H, et al. Stem Cells, 2015 Mar. PMID 25420467
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
forkhead box protein N3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045263.2 → NP_001038728.2  forkhead box protein N3

    Status: VALIDATED

    Source sequence(s)
    BX927159, BX927196, CR762468
    UniProtKB/TrEMBL
    A0A8M9PED3, K7DY44
    Related
    ENSDARP00000126371.1, ENSDART00000151904.3
    Conserved Domains (1) summary
    pfam00250
    Location:114 → 200
    Forkhead; Forkhead domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    16565185..16741175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467224.2 → XP_021322899.1  forkhead box protein N3 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PED3, K7DY44
    Conserved Domains (1) summary
    pfam00250
    Location:114 → 200
    Forkhead; Forkhead domain

  2. XM_068214453.1 → XP_068070554.1  forkhead box protein N3 isoform X1

  3. XM_021467225.2 → XP_021322900.1  forkhead box protein N3 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PED3, K7DY44
    Conserved Domains (1) summary
    pfam00250
    Location:114 → 200
    Forkhead; Forkhead domain

  4. XM_009292896.4 → XP_009291171.1  forkhead box protein N3 isoform X1

    See identical proteins and their annotated locations for XP_009291171.1

    UniProtKB/TrEMBL
    A0A8M9PED3, K7DY44
    Conserved Domains (1) summary
    pfam00250
    Location:114 → 200
    Forkhead; Forkhead domain
Nucleotide Protein
Heading Accession and Version

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