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Znrf1 zinc and ring finger 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 690769, updated on 18-Sep-2024

Summary

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Official Symbol
Znrf1provided by RGD
Official Full Name
zinc and ring finger 1provided by RGD
Primary source
RGD:1592195
See related
EnsemblRapid:ENSRNOG00000019028 AllianceGenome:RGD:1592195
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein K48-linked ubiquitination. Predicted to be located in cytosol; endosome; and membrane. Orthologous to human ZNRF1 (zinc and ring finger 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 174.1), Muscle (RPKM 172.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Znrf1 in Genome Data Viewer
Location:
19q12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (56403816..56490901)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (39496414..39581600)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (43750205..43834962)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 59 Neighboring gene 60S ribosomal protein L29-like Neighboring gene uncharacterized LOC120098630 Neighboring gene uncharacterized LOC134483371 Neighboring gene lactate dehydrogenase D Neighboring gene zinc finger protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation. Wakatsuki S, et al. Nat Cell Biol, 2011 Nov 6. PMID 22057101
  2. ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. Hoxhaj G, et al. J Cell Sci, 2012 Oct 1. PMID 22797923, Free PMC Article
  3. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of autophagosome-lysosome fusion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of autophagosome-lysosome fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase ZNRF1
Names
zinc and ring finger 1, E3 ubiquitin protein ligase
NP_001388008.1
NP_001388009.1
XP_006255712.1
XP_006255713.1
XP_006255714.1
XP_038954193.1
XP_038954194.1
XP_038954195.1
XP_038954196.1
XP_063134365.1
XP_063134366.1
XP_063134367.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401079.1 → NP_001388008.1  E3 ubiquitin-protein ligase ZNRF1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A6IZ93, D3ZIQ9
    Related
    ENSRNOP00000093092.2, ENSRNOT00000095580.2

  2. NM_001401080.1 → NP_001388009.1  E3 ubiquitin-protein ligase ZNRF1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A6IZ93, D3ZIQ9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    56403816..56490901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063278295.1 → XP_063134365.1  E3 ubiquitin-protein ligase ZNRF1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUZ1

  2. XM_006255650.4 → XP_006255712.1  E3 ubiquitin-protein ligase ZNRF1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUZ1
    Conserved Domains (1) summary
    cd16694
    Location:216 → 261
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

  3. XM_006255652.4 → XP_006255714.1  E3 ubiquitin-protein ligase ZNRF1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUZ1
    Conserved Domains (1) summary
    cd16694
    Location:216 → 261
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

  4. XM_006255651.4 → XP_006255713.1  E3 ubiquitin-protein ligase ZNRF1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZUZ1
    Related
    ENSRNOP00000083192.1, ENSRNOT00000117072.2
    Conserved Domains (1) summary
    cd16694
    Location:216 → 261
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

  5. XM_039098265.2 → XP_038954193.1  E3 ubiquitin-protein ligase ZNRF1 isoform X2

    UniProtKB/TrEMBL
    A6IZ93, D3ZIQ9
    Conserved Domains (1) summary
    cd16694
    Location:182 → 227
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

  6. XM_063278296.1 → XP_063134366.1  E3 ubiquitin-protein ligase ZNRF1 isoform X2

    UniProtKB/TrEMBL
    A6IZ93, D3ZIQ9

  7. XM_039098266.2 → XP_038954194.1  E3 ubiquitin-protein ligase ZNRF1 isoform X3

  8. XM_039098268.2 → XP_038954196.1  E3 ubiquitin-protein ligase ZNRF1 isoform X5

  9. XM_039098267.2 → XP_038954195.1  E3 ubiquitin-protein ligase ZNRF1 isoform X4

  10. XM_063278297.1 → XP_063134367.1  E3 ubiquitin-protein ligase ZNRF1 isoform X6

Nucleotide Protein Strain
Heading Accession and Version

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