U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tktl1 transketolase-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 689374, updated on 2-Nov-2024

Summary

Symbol
Tktl1provided by RGD
Full Name
transketolase-like 1provided by RGD
Primary source
RGD:1593490
See related
EnsemblRapid:ENSRNOG00000055557 AllianceGenome:RGD:1593490
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable thiamine pyrophosphate binding activity and transketolase activity. Predicted to be located in cytosol. Orthologous to human TKTL1 (transketolase like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 12.6) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Tktl1 in Genome Data Viewer
Location:
Xq37
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (157105455..157138510)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (151954261..151987208)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (156507797..156540733, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene protein Mis18-beta-like Neighboring gene opsin 1, medium wave sensitive Neighboring gene testis expressed 28 Neighboring gene filamin A Neighboring gene emerin

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables thiamine pyrophosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transketolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transketolase-like protein 1
NP_001103004.1
XP_038956008.1
XP_063136378.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109534.1NP_001103004.1  transketolase-like protein 1

    See identical proteins and their annotated locations for NP_001103004.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474099
    UniProtKB/TrEMBL
    A6KRS6, D3ZPV2
    Related
    ENSRNOP00000071464.1, ENSRNOT00000091029.3
    Conserved Domains (4) summary
    cd07033
    Location:294447
    TPP_PYR_DXS_TK_like; Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins
    PRK05899
    Location:52591
    PRK05899; transketolase; Reviewed
    pfam02780
    Location:464586
    Transketolase_C; Transketolase, C-terminal domain
    cl01629
    Location:29245
    TPP_enzymes; Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    157105455..157138510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063280308.1XP_063136378.1  transketolase-like protein 1 isoform X2

  2. XM_039100080.2XP_038956008.1  transketolase-like protein 1 isoform X1

    Conserved Domains (2) summary
    COG3958
    Location:136445
    TktA2; Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]
    cl01629
    Location:196
    TPP_enzymes; Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and ...