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Sec24c SEC24 homolog C, COPII coat complex component [ Rattus norvegicus (Norway rat) ]

Gene ID: 685144, updated on 2-Nov-2024

Summary

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Official Symbol
Sec24cprovided by RGD
Official Full Name
SEC24 homolog C, COPII coat complex componentprovided by RGD
Primary source
RGD:1597739
See related
EnsemblRapid:ENSRNOG00000009042 AllianceGenome:RGD:1597739
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable SNARE binding activity and zinc ion binding activity. Predicted to be involved in COPII-coated vesicle cargo loading. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in cytosol. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Orthologous to human SEC24C (SEC24 homolog C, COPII coat complex component). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 180.5), Liver (RPKM 167.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sec24c in Genome Data Viewer
Location:
15p16
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (3651714..3674420, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (3602460..3624524, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (4035196..4057209, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene fucosyltransferase 11 Neighboring gene small nucleolar RNA SNORA51 Neighboring gene small nucleolar RNA SNORA51

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Axonal targeting of the serotonin transporter in cultured rat dorsal raphe neurons is specified by SEC24C-dependent export from the endoplasmic reticulum. Montgomery TR, et al. J Neurosci, 2014 Apr 30. PMID 24790205, Free PMC Article
  2. A family of mammalian proteins homologous to yeast Sec24p. Tang BL, et al. Biochem Biophys Res Commun, 1999 May 19. PMID 10329445
  3. Mammalian COPII coat component SEC24C is required for embryonic development in mice. Adams EJ, et al. J Biol Chem, 2014 Jul 25. PMID 24876386, Free PMC Article
  4. Sec24 proteins and sorting at the endoplasmic reticulum. Pagano A, et al. J Biol Chem, 1999 Mar 19. PMID 10075675
  5. Selective export of human GPI-anchored proteins from the endoplasmic reticulum. Bonnon C, et al. J Cell Sci, 2010 May 15. PMID 20427317

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Axonal delivery of serotonin transporter is contingent on recruitment of SEC24C in the endoplasmic reticulum.
    Title: Axonal targeting of the serotonin transporter in cultured rat dorsal raphe neurons is specified by SEC24C-dependent export from the endoplasmic reticulum.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in COPII-coated vesicle cargo loading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in COPII-coated vesicle cargo loading ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COPII vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COPII vesicle coat ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein transport protein Sec24C
Names
SEC24 family, member C
SEC24 related gene family, member C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109456.1 → NP_001102926.1  protein transport protein Sec24C

    See identical proteins and their annotated locations for NP_001102926.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474061
    UniProtKB/TrEMBL
    B5DEG8, F7ET87
    Related
    ENSRNOP00000012269.3, ENSRNOT00000012270.6
    Conserved Domains (7) summary
    COG5028
    Location:181 → 1091
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    cd01479
    Location:500 → 759
    Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam00626
    Location:962 → 1037
    Gelsolin; Gelsolin repeat
    pfam04810
    Location:423 → 460
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:848 → 944
    Sec23_helical; Sec23/Sec24 helical domain
    pfam08033
    Location:749 → 832
    Sec23_BS; Sec23/Sec24 beta-sandwich domain
    cl23807
    Location:143 → 233
    WWbp; WW-domain ligand protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    3651714..3674420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093660.2 → XP_038949588.1  protein transport protein Sec24C isoform X4

    UniProtKB/TrEMBL
    A0A0G2JZF0
    Related
    ENSRNOP00000071021.1, ENSRNOT00000090352.3
    Conserved Domains (2) summary
    PHA03247
    Location:7 → 269
    PHA03247; large tegument protein UL36; Provisional
    COG5028
    Location:181 → 1052
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

  2. XM_006251659.5 → XP_006251721.1  protein transport protein Sec24C isoform X3

    Conserved Domains (7) summary
    COG5028
    Location:181 → 1075
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    cd01479
    Location:484 → 743
    Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam00626
    Location:946 → 1021
    Gelsolin; Gelsolin repeat
    pfam04810
    Location:407 → 444
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:832 → 928
    Sec23_helical; Sec23/Sec24 helical domain
    pfam08033
    Location:733 → 816
    Sec23_BS; Sec23/Sec24 beta-sandwich domain
    pfam11235
    Location:93 → 256
    Med25_SD1; Mediator complex subunit 25 synapsin 1

  3. XM_006251656.5 → XP_006251718.1  protein transport protein Sec24C isoform X1

    See identical proteins and their annotated locations for XP_006251718.1

    UniProtKB/TrEMBL
    A0A0G2K626
    Related
    ENSRNOP00000073649.2, ENSRNOT00000084350.3
    Conserved Domains (2) summary
    PHA03247
    Location:7 → 343
    PHA03247; large tegument protein UL36; Provisional
    COG5028
    Location:181 → 1114
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

  4. XM_063274641.1 → XP_063130711.1  protein transport protein Sec24C isoform X2

    UniProtKB/TrEMBL
    B5DEG8, F7ET87

  5. XM_006251657.5 → XP_006251719.1  protein transport protein Sec24C isoform X1

    See identical proteins and their annotated locations for XP_006251719.1

    UniProtKB/TrEMBL
    A0A0G2K626
    Conserved Domains (2) summary
    PHA03247
    Location:7 → 343
    PHA03247; large tegument protein UL36; Provisional
    COG5028
    Location:181 → 1114
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

  6. XM_063274642.1 → XP_063130712.1  protein transport protein Sec24C isoform X2

    UniProtKB/TrEMBL
    B5DEG8, F7ET87

  7. XM_017599801.2 → XP_017455290.1  protein transport protein Sec24C isoform X2

    UniProtKB/TrEMBL
    B5DEG8, F7ET87
    Conserved Domains (7) summary
    COG5028
    Location:181 → 1091
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
    cd01479
    Location:500 → 759
    Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam00626
    Location:962 → 1037
    Gelsolin; Gelsolin repeat
    pfam04810
    Location:423 → 460
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:848 → 944
    Sec23_helical; Sec23/Sec24 helical domain
    pfam08033
    Location:749 → 832
    Sec23_BS; Sec23/Sec24 beta-sandwich domain
    cl23807
    Location:143 → 233
    WWbp; WW-domain ligand protein

  8. XM_039093659.2 → XP_038949587.1  protein transport protein Sec24C isoform X1

    UniProtKB/TrEMBL
    A0A0G2K626
    Conserved Domains (2) summary
    PHA03247
    Location:7 → 343
    PHA03247; large tegument protein UL36; Provisional
    COG5028
    Location:181 → 1114
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
Nucleotide Protein Strain
Heading Accession and Version

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