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Prodh proline dehydrogenase [ Rattus norvegicus (Norway rat) ]

Gene ID: 680409, updated on 2-Nov-2024

Summary

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Official Symbol
Prodhprovided by RGD
Official Full Name
proline dehydrogenaseprovided by RGD
Primary source
RGD:1590932
See related
EnsemblRapid:ENSRNOG00000000281 AllianceGenome:RGD:1590932
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Prodh1
Summary
Enables amino acid binding activity and proline dehydrogenase activity. Predicted to be involved in proline catabolic process to glutamate and regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in amino acid metabolic disorder; hyperprolinemia type 1; and schizophrenia 4. Orthologous to human PRODH (proline dehydrogenase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 361.7), Heart (RPKM 180.2) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prodh in Genome Data Viewer
Location:
11q23
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96414275..96431604)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (82910043..82927305)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87058478..87075785)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555338 Neighboring gene reticulon 4 receptor Neighboring gene DiGeorge syndrome critical region gene 6 Neighboring gene V-set pre-B cell surrogate light chain 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. [Necrotizing scleritis--successful treatment with solcoseryl]. Dabrowska A. Klin Oczna, 1992 Jul-Aug. PMID 1300406
  2. Functional consequences of PRODH missense mutations. Bender HU, et al. Am J Hum Genet, 2005 Mar. PMID 15662599, Free PMC Article
  3. The severe form of type I hyperprolinaemia results from homozygous inactivation of the PRODH gene. Jacquet H, et al. J Med Genet, 2003 Jan. PMID 12525555, Free PMC Article
  4. Mechanism-based inhibition of proline dehydrogenase by proline analogues. Tritsch D, et al. Biochim Biophys Acta, 1993 Sep 3. PMID 8373828
  5. PRODH mutations and hyperprolinemia in a subset of schizophrenic patients. Jacquet H, et al. Hum Mol Genet, 2002 Sep 15. PMID 12217952

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables FAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables FAD binding ISO
Inferred from Sequence Orthology
more info
  
enables amino acid binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables proline dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proline dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables proline dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in proline catabolic process to glutamate IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
proline dehydrogenase 1, mitochondrial
Names
proline dehydrogenase (oxidase) 1
proline dehydrogenase (proline oxidase)
proline dehydrogenase, mitochondrial
NP_001129250.3
XP_006248704.5
XP_006248705.2
XP_008767125.2
XP_063126832.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135778.3 → NP_001129250.3  proline dehydrogenase 1, mitochondrial isoform 4

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000011
    Conserved Domains (1) summary
    PLN02681
    Location:47 → 594
    PLN02681; proline dehydrogenase

  2. NM_001431659.1 → NP_001418588.1  proline dehydrogenase 1, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    F1MAR6

  3. NM_001431660.1 → NP_001418589.1  proline dehydrogenase 1, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011

  4. NM_001431661.1 → NP_001418590.1  proline dehydrogenase 1, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A0A0G2K2S1

RNA

  1. NR_197240.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    96414275..96431604
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008768903.4 → XP_008767125.2  proline dehydrogenase 1, mitochondrial isoform X4

    Conserved Domains (1) summary
    PLN02681
    Location:3 → 492
    PLN02681; proline dehydrogenase

  2. XM_006248642.5 → XP_006248704.5  proline dehydrogenase 1, mitochondrial isoform X1

    Related
    ENSRNOP00000002576.8, ENSRNOT00000002576.9

  3. XM_063270762.1 → XP_063126832.1  proline dehydrogenase 1, mitochondrial isoform X2

    Related
    ENSRNOP00000100179.1, ENSRNOT00000126432.1

  4. XM_006248643.4 → XP_006248705.2  proline dehydrogenase 1, mitochondrial isoform X3

    Related
    ENSRNOP00000072350.2, ENSRNOT00000082855.3
    Conserved Domains (1) summary
    PLN02681
    Location:19 → 533
    PLN02681; proline dehydrogenase

RNA

  1. XR_005491055.2 RNA Sequence

  2. XR_005491056.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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