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Decr1 2,4-dienoyl CoA reductase 1, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 67460, updated on 3-Nov-2024

Summary

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Official Symbol
Decr1provided by MGI
Official Full Name
2,4-dienoyl CoA reductase 1, mitochondrialprovided by MGI
Primary source
MGI:MGI:1914710
See related
Ensembl:ENSMUSG00000028223 AllianceGenome:MGI:1914710
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Decr; Nadph; 1200012F07Rik
Summary
Predicted to enable 2,4-dienoyl-CoA reductase (NADPH) activity; NADPH binding activity; and identical protein binding activity. Involved in positive regulation of cold-induced thermogenesis. Located in mitochondrion. Is expressed in axial skeleton. Orthologous to human DECR1 (2,4-dienoyl-CoA reductase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in heart adult (RPKM 41.1), liver E18 (RPKM 22.5) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Decr1 in Genome Data Viewer
Location:
4 A2; 4 6.66 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (15917240..15945377, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (15917240..15945377, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene calbindin 1 Neighboring gene predicted gene, 26148 Neighboring gene microRNA 6400 Neighboring gene nibrin Neighboring gene STARR-positive B cell enhancer ABC_E6155 Neighboring gene oxidative stress induced growth inhibitor family member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mitochondrial 2,4-dienoyl-CoA reductase (Decr) deficiency and impairment of thermogenesis in mouse brown adipose tissue. Mäkelä AM, et al. Sci Rep, 2019 Aug 19. PMID 31427678, Free PMC Article
  2. Mitochondrial 2,4-dienoyl-CoA reductase deficiency in mice results in severe hypoglycemia with stress intolerance and unimpaired ketogenesis. Miinalainen IJ, et al. PLoS Genet, 2009 Jul. PMID 19578400, Free PMC Article
  3. Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development. Zhou L, et al. FASEB J, 2017 Jan. PMID 27694478, Free PMC Article
  4. Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala. Boyle MP, et al. J Comp Neurol, 2011 Aug 1. PMID 21491433
  5. Searching QTL by gene expression: analysis of diabesity. Brown AC, et al. BMC Genet, 2005 Mar 10. PMID 15760467, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fasted Decr(-/-) mice displayed increased serum acylcarnitines and unimpaired ketogenesis.
    Title: Mitochondrial 2,4-dienoyl-CoA reductase deficiency in mice results in severe hypoglycemia with stress intolerance and unimpaired ketogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2,4-dienoyl-CoA reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2,4-dienoyl-CoA reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables 2,4-dienoyl-CoA reductase (NADPH) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables NADPH binding IEA
Inferred from Electronic Annotation
more info
  
enables NADPH binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid beta-oxidation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic complex IEA
Inferred from Electronic Annotation
more info
  
part_of catalytic complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial
Names
2,4-dienoyl-CoA reductase, mitochondrial
NP_080448.1
XP_036020258.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026172.4 → NP_080448.1  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial precursor

    See identical proteins and their annotated locations for NP_080448.1

    Status: VALIDATED

    Source sequence(s)
    BC046972
    Consensus CDS
    CCDS17985.1
    UniProtKB/Swiss-Prot
    Q9CQ62, Q9DCI7
    UniProtKB/TrEMBL
    Q4FJK0
    Related
    ENSMUSP00000029877.9, ENSMUST00000029877.9
    Conserved Domains (2) summary
    PRK07677
    Location:59 → 303
    PRK07677; short chain dehydrogenase; Provisional
    cd05369
    Location:57 → 303
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    15917240..15945377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164365.1 → XP_036020258.1  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform X1

    Conserved Domains (1) summary
    cd05369
    Location:7 → 253
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQ62.1 GenPept UniProtKB/Swiss-Prot:Q9CQ62

Gene LinkOut

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