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Map1lc3b microtubule-associated protein 1 light chain 3 beta [ Mus musculus (house mouse) ]

Gene ID: 67443, updated on 28-Oct-2024

Summary

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Official Symbol
Map1lc3bprovided by MGI
Official Full Name
microtubule-associated protein 1 light chain 3 betaprovided by MGI
Primary source
MGI:MGI:1914693
See related
Ensembl:ENSMUSG00000031812 AllianceGenome:MGI:1914693
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Atg8; LC3b; Map1lc3; MAP1A/MAP1B; 1010001C15Rik
Summary
Predicted to enable several functions, including microtubule binding activity; phosphatidylethanolamine binding activity; and ubiquitin protein ligase binding activity. Involved in autophagy. Acts upstream of or within positive regulation of mucus secretion. Located in axoneme; membrane; and vacuole. Is expressed in several structures, including central nervous system; heart; limb; peripheral nervous system ganglion; and sensory organ. Orthologous to several human genes including MAP1LC3B2 (microtubule associated protein 1 light chain 3 beta 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 80.9), adrenal adult (RPKM 77.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Map1lc3b in Genome Data Viewer
Location:
8 E1; 8 70.67 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (122317177..122325499)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (121590438..121598760)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2882 Neighboring gene nuclear encoded tRNA methionine 17 (anticodon CAT) Neighboring gene predicted gene, 17786 Neighboring gene zinc finger, CCHC domain containing 14 Neighboring gene VISTA enhancer mm323 Neighboring gene predicted gene, 46065 Neighboring gene junctophilin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Individual Atg8 paralogs and a bacterial metabolite sequentially promote hierarchical CASM-xenophagy induction and transition. Sakuma C, et al. Cell Rep, 2024 May 28. PMID 38656870
  2. Microtubule-associated protein 1B is involved in the initial stages of axonogenesis in peripheral nervous system cultured neurons. Gonzalez-Billault C, et al. Brain Res, 2002 Jul 5. PMID 12088839
  3. Cell-Penetrating Nanoparticles Activate the Inflammasome to Enhance Antibody Production by Targeting Microtubule-Associated Protein 1-Light Chain 3 for Degradation. Zhu M, et al. ACS Nano, 2020 Mar 24. PMID 32057231, Free PMC Article
  4. Peroxisome turnover and diurnal modulation of antioxidant activity in retinal pigment epithelia utilizes microtubule-associated protein 1 light chain 3B (LC3B). Daniele LL, et al. Am J Physiol Cell Physiol, 2019 Dec 1. PMID 31577510, Free PMC Article
  5. Susceptibility of microtubule-associated protein 1 light chain 3β (MAP1LC3B/LC3B) knockout mice to lung injury and fibrosis. Kesireddy VS, et al. FASEB J, 2019 Nov. PMID 31431059, Free PMC Article

See all (166) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Individual Atg8 paralogs and a bacterial metabolite sequentially promote hierarchical CASM-xenophagy induction and transition.
    Title: Individual Atg8 paralogs and a bacterial metabolite sequentially promote hierarchical CASM-xenophagy induction and transition.
  2. IGF2BP1/IMP1 Deletion Enhances a Facultative Stem Cell State via Regulation of MAP1LC3B.
    Title: IGF2BP1/IMP1 Deletion Enhances a Facultative Stem Cell State via Regulation of MAP1LC3B.
  3. LC3B is lipidated to large lipid droplets during prolonged starvation for noncanonical autophagy.
    Title: LC3B is lipidated to large lipid droplets during prolonged starvation for noncanonical autophagy.
  4. Transcriptomic Changes Predict Metabolic Alterations in LC3 Associated Phagocytosis in Aged Mice.
    Title: Transcriptomic Changes Predict Metabolic Alterations in LC3 Associated Phagocytosis in Aged Mice.
  5. BNIP3-dependent mitophagy promotes cytosolic localization of LC3B and metabolic homeostasis in the liver.
    Title: BNIP3-dependent mitophagy promotes cytosolic localization of LC3B and metabolic homeostasis in the liver.
  6. ATG7 is dispensable for LC3-PE conjugation in thioglycolate-elicited mouse peritoneal macrophages.
    Title: ATG7 is dispensable for LC3-PE conjugation in thioglycolate-elicited mouse peritoneal macrophages.
  7. Perturbation of PI3K/Akt signaling affected autophagy modulation in dystrophin-deficient myoblasts.
    Title: Perturbation of PI3K/Akt signaling affected autophagy modulation in dystrophin-deficient myoblasts.
  8. Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation.
    Title: Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation.
  9. STING induces LC3B lipidation onto single-membrane vesicles via the V-ATPase and ATG16L1-WD40 domain.
    Title: STING induces LC3B lipidation onto single-membrane vesicles via the V-ATPase and ATG16L1-WD40 domain.
  10. Cell-Penetrating Nanoparticles Activate the Inflammasome to Enhance Antibody Production by Targeting Microtubule-Associated Protein 1-Light Chain 3 for Degradation.
    Title: Cell-Penetrating Nanoparticles Activate the Inflammasome to Enhance Antibody Production by Targeting Microtubule-Associated Protein 1-Light Chain 3 for Degradation.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC118046

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ceramide binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylethanolamine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylethanolamine binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to nitrogen starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to starvation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitophagy ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of mucus secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of mucus secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in autolysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in autophagosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in autophagosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in autophagosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in autophagosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in axoneme IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
part_of microtubule associated complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
microtubule-associated proteins 1A/1B light chain 3B
Names
MAP1 light chain 3-like protein 2
MAP1A/MAP1B light chain 3 B
autophagy-related protein LC3 B
autophagy-related ubiquitin-like modifier LC3 B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364358.1 → NP_001351287.1  microtubule-associated proteins 1A/1B light chain 3B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC182458
    Consensus CDS
    CCDS90470.1
    UniProtKB/TrEMBL
    M0QWC2
    Related
    ENSMUSP00000137754.2, ENSMUST00000181948.2
    Conserved Domains (1) summary
    cd01611
    Location:7 → 155
    GABARAP; Ubiquitin domain of GABA-receptor-associated protein

  2. NM_026160.5 → NP_080436.1  microtubule-associated proteins 1A/1B light chain 3B isoform 1

    See identical proteins and their annotated locations for NP_080436.1

    Status: VALIDATED

    Source sequence(s)
    AC182458
    Consensus CDS
    CCDS22726.1
    UniProtKB/Swiss-Prot
    Q3U9W5, Q9CQV6, Q9D1R0
    UniProtKB/TrEMBL
    Q2TBF9
    Related
    ENSMUSP00000034270.10, ENSMUST00000034270.17
    Conserved Domains (1) summary
    cd17235
    Location:5 → 119
    Ubl_ATG8_MAP1LC3B; ubiquitin-like (Ubl) domain found in microtubule associate protein 1 light chain 3B (MAP1LC3B)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    122317177..122325499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQV6.3 GenPept UniProtKB/Swiss-Prot:Q9CQV6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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