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Fbxo5 F-box protein 5 [ Mus musculus (house mouse) ]

Gene ID: 67141, updated on 2-Nov-2024

Summary

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Official Symbol
Fbxo5provided by MGI
Official Full Name
F-box protein 5provided by MGI
Primary source
MGI:MGI:1914391
See related
Ensembl:ENSMUSG00000019773 AllianceGenome:MGI:1914391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Emi1; Fbxo31; 2510044I10Rik
Summary
Predicted to enable anaphase-promoting complex binding activity; protein kinase binding activity; and ubiquitin ligase inhibitor activity. Involved in regulation of mitotic cell cycle. Acts upstream of or within several processes, including microtubule cytoskeleton organization; negative regulation of meiotic nuclear division; and oocyte maturation. Located in cytoplasm and meiotic spindle. Is expressed in several structures, including brain; early conceptus; gonad; metanephros; and spleen. Orthologous to human FBXO5 (F-box protein 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver E14 (RPKM 31.2), liver E14.5 (RPKM 24.6) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Fbxo5 in Genome Data Viewer
Location:
10 A1; 10 1.91 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (5749155..5755465, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (5799158..5805465, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 47679 Neighboring gene STARR-seq mESC enhancer starr_25597 Neighboring gene predicted gene, 30617 Neighboring gene STARR-seq mESC enhancer starr_25595 Neighboring gene predicted gene, 53609 Neighboring gene STARR-positive B cell enhancer ABC_E3873 Neighboring gene STARR-positive B cell enhancer ABC_E3872 Neighboring gene mitochondrial translational release factor 1-like Neighboring gene regulator of G-protein signaling 17 Neighboring gene predicted gene, 18902

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1). Marangos P, et al. J Cell Biol, 2007 Jan 1. PMID 17190794, Free PMC Article
  2. Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Reimann JD, et al. Cell, 2001 Jun 1. PMID 11389834
  3. Mouse emi1 has an essential function in mitotic progression during early embryogenesis. Lee H, et al. Mol Cell Biol, 2006 Jul. PMID 16809773, Free PMC Article
  4. Cell cycle adaptations of embryonic stem cells. Ballabeni A, et al. Proc Natl Acad Sci U S A, 2011 Nov 29. PMID 22084091, Free PMC Article
  5. Mammalian Emi2 mediates cytostatic arrest and transduces the signal for meiotic exit via Cdc20. Shoji S, et al. EMBO J, 2006 Feb 22. PMID 16456547, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables anaphase-promoting complex binding ISO
Inferred from Sequence Orthology
more info
  
enables anaphase-promoting complex binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular function inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin ligase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin ligase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within microtubule polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA endoreduplication ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA endoreduplication ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cellular senescence ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of meiotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of meiotic nuclear division IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of mitotic metaphase/anaphase transition IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mitotic metaphase/anaphase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in negative regulation of ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within oocyte maturation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within oocyte maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of G2/M transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of biomineral tissue development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of biomineral tissue development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of meiosis I ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in positive regulation of mesenchymal stem cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mesenchymal stem cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of meiotic nuclear division IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spindle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within spindle assembly involved in female meiosis I IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within vesicle organization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in meiotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
F-box only protein 5
Names
early mitotic inhibitor 1
f-box only protein 31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429431.1 → NP_001416360.1  F-box only protein 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC159325

  2. NM_025995.3 → NP_080271.2  F-box only protein 5 isoform 1

    See identical proteins and their annotated locations for NP_080271.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC159325
    Consensus CDS
    CCDS56683.1
    UniProtKB/Swiss-Prot
    Q7TSG3
    Related
    ENSMUSP00000019907.8, ENSMUST00000019907.8
    Conserved Domains (1) summary
    smart00256
    Location:232 → 264
    FBOX; A Receptor for Ubiquitination Targets

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    5749155..5755465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155959.1 → XP_036011852.1  F-box only protein 5 isoform X1

    Conserved Domains (2) summary
    smart00256
    Location:194 → 226
    FBOX; A Receptor for Ubiquitination Targets
    pfam01485
    Location:302 → 352
    IBR; IBR domain, a half RING-finger domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TSG3.1 GenPept UniProtKB/Swiss-Prot:Q7TSG3

Gene LinkOut

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