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Acadsb acyl-Coenzyme A dehydrogenase, short/branched chain [ Mus musculus (house mouse) ]

Gene ID: 66885, updated on 3-Nov-2024

Summary

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Official Symbol
Acadsbprovided by MGI
Official Full Name
acyl-Coenzyme A dehydrogenase, short/branched chainprovided by MGI
Primary source
MGI:MGI:1914135
See related
Ensembl:ENSMUSG00000030861 AllianceGenome:MGI:1914135
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SBCAD; 2-MEBCAD; 1300003O09Rik
Summary
Predicted to enable electron transfer activity; identical protein binding activity; and short-chain 2-methyl fatty acyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid metabolic process and isoleucine catabolic process. Predicted to act upstream of or within acyl-CoA metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ACADSB (acyl-CoA dehydrogenase short/branched chain). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 14.5), subcutaneous fat pad adult (RPKM 14.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Acadsb in Genome Data Viewer
Location:
7 F3; 7 74.03 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (131012330..131047940)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (131410601..131446211)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310057M21 gene Neighboring gene STARR-positive B cell enhancer ABC_E9713 Neighboring gene STARR-positive B cell enhancer ABC_E8214 Neighboring gene STARR-seq mESC enhancer starr_20280 Neighboring gene phosphoseryl-tRNA kinase Neighboring gene STARR-seq mESC enhancer starr_20281 Neighboring gene IKAROS family zinc finger 5 Neighboring gene STARR-positive B cell enhancer ABC_E4981 Neighboring gene motile sperm domain containing 3 pseudogene Neighboring gene predicted gene, 39099

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LncMyoD Promotes Skeletal Myogenesis and Regulates Skeletal Muscle Fiber-Type Composition by Sponging miR-370-3p. Zhang P, et al. Genes (Basel), 2021 Apr 17. PMID 33920575, Free PMC Article
  2. Mitochondrial FAD shortage in SLC25A32 deficiency affects folate-mediated one-carbon metabolism. Peng MZ, et al. Cell Mol Life Sci, 2022 Jun 21. PMID 35727412, Free PMC Article
  3. PPARα-Target Gene Expression Requires TIS21(/BTG2) Gene in Liver of the C57BL/6 Mice under Fasting Condition. Hong AE, et al. Mol Cells, 2018 Feb 28. PMID 29385670, Free PMC Article
  4. eXPRESSION: an in silico tool to predict patterns of gene expression. Ferguson DA, et al. Gene Expr Patterns, 2005 Jun. PMID 15939374
  5. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Kim SC, et al. Mol Cell, 2006 Aug. PMID 16916647

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncMyoD Promotes Skeletal Myogenesis and Regulates Skeletal Muscle Fiber-Type Composition by Sponging miR-370-3p.
    Title: LncMyoD Promotes Skeletal Myogenesis and Regulates Skeletal Muscle Fiber-Type Composition by Sponging miR-370-3p.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acyl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables electron transfer activity ISO
Inferred from Sequence Orthology
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables short-chain 2-methyl fatty acyl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables short-chain 2-methyl fatty acyl-CoA dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables short-chain fatty acyl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables short-chain fatty acyl-CoA dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within acyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in isoleucine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in isoleucine catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in isoleucine catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
Names
2-methyl branched chain acyl-CoA dehydrogenase
2-methylbutyryl-coenzyme A dehydrogenase
NP_080102.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025826.4 → NP_080102.1  short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

    See identical proteins and their annotated locations for NP_080102.1

    Status: VALIDATED

    Source sequence(s)
    AK004889, AW987640, BY296718
    Consensus CDS
    CCDS21916.1
    UniProtKB/Swiss-Prot
    Q9DBL1
    UniProtKB/TrEMBL
    Q7TMY2
    Related
    ENSMUSP00000015829.8, ENSMUST00000015829.15
    Conserved Domains (2) summary
    cd01158
    Location:59 → 430
    SCAD_SBCAD; Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases
    COG1960
    Location:57 → 428
    CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    131012330..131047940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003946541.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBL1.1 GenPept UniProtKB/Swiss-Prot:Q9DBL1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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