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Pnpla2 patatin-like phospholipase domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 66853, updated on 2-Nov-2024

Summary

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Official Symbol
Pnpla2provided by MGI
Official Full Name
patatin-like phospholipase domain containing 2provided by MGI
Primary source
MGI:MGI:1914103
See related
Ensembl:ENSMUSG00000025509 AllianceGenome:MGI:1914103
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Atgl; TTS-2.2; 0610039C21Rik; 1110001C14Rik
Summary
Enables triacylglycerol lipase activity. Involved in several processes, including acylglycerol metabolic process; negative regulation of sequestering of triglyceride; and positive regulation of triglyceride catabolic process. Acts upstream of or within cellular lipid catabolic process and lipid droplet organization. Located in cytosol and lipid droplet. Is expressed in brown fat. Orthologous to human PNPLA2 (patatin like phospholipase domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in mammary gland adult (RPKM 647.4), subcutaneous fat pad adult (RPKM 559.9) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Pnpla2 in Genome Data Viewer
Location:
7 F5; 7 86.81 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141035101..141040656)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141455188..141460743)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene p53 induced death domain protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E1097 Neighboring gene ribosomal protein lateral stalk subunit P2 Neighboring gene small nucleolar RNA, H/ACA box 52 Neighboring gene STARR-positive B cell enhancer ABC_E9305 Neighboring gene calcium release activated channel regulator 2B Neighboring gene predicted gene 10575 Neighboring gene CD151 antigen

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Outside-in signaling by femoral cuff injury induces a distinct vascular lesion in adipose triglyceride lipase knockout mice. Noguchi H, et al. Histol Histopathol, 2021 Jan. PMID 33231284
  2. Adipose Triglyceride Lipase Deficiency Attenuates In Vitro Thrombus Formation without Affecting Platelet Activation and Bleeding In Vivo. Goeritzer M, et al. Cells, 2022 Mar 1. PMID 35269472, Free PMC Article
  3. Adipose triglyceride lipase mediates lipolysis and lipid mobilization in response to iron-mediated negative energy balance. Romero AR, et al. iScience, 2022 Mar 18. PMID 35265813, Free PMC Article
  4. Enterocyte-specific ATGL overexpression affects intestinal and systemic cholesterol homeostasis. Korbelius M, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2022 Apr. PMID 35150895, Free PMC Article
  5. Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction. Kienesberger PC, et al. Mol Cell Biol, 2012 Feb. PMID 22158969, Free PMC Article

See all (225) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Adipose triglyceride lipase suppresses noncanonical inflammasome by hydrolyzing LPS.
    Title: Adipose triglyceride lipase suppresses noncanonical inflammasome by hydrolyzing LPS.
  2. SLC25A28 Overexpression Promotes Adipogenesis by Reducing ATGL.
    Title: SLC25A28 Overexpression Promotes Adipogenesis by Reducing ATGL.
  3. Glucose controls lipolysis through Golgi PtdIns4P-mediated regulation of ATGL.
    Title: Glucose controls lipolysis through Golgi PtdIns4P-mediated regulation of ATGL.
  4. Renal tubule-specific Atgl deletion links kidney lipid metabolism to glucagon-like peptide 1 and insulin secretion independent of renal inflammation or lipotoxicity.
    Title: Renal tubule-specific Atgl deletion links kidney lipid metabolism to glucagon-like peptide 1 and insulin secretion independent of renal inflammation or lipotoxicity.
  5. Unmasking crucial residues in adipose triglyceride lipase for coactivation with comparative gene identification-58.
    Title: Unmasking crucial residues in adipose triglyceride lipase for coactivation with comparative gene identification-58.
  6. PNPLA2 mobilizes retinyl esters from retinosomes and promotes the generation of 11-cis-retinal in the visual cycle.
    Title: PNPLA2 mobilizes retinyl esters from retinosomes and promotes the generation of 11-cis-retinal in the visual cycle.
  7. Ablation of pigment epithelium-derived factor receptor (PEDF-R/Pnpla2) causes photoreceptor degeneration.
    Title: Ablation of pigment epithelium-derived factor receptor (PEDF-R/Pnpla2) causes photoreceptor degeneration.
  8. Adipose Triglyceride Lipase Deficiency Aggravates Angiotensin II-Induced Atrial Fibrillation by Reducing Peroxisome Proliferator-Activated Receptor alpha Activation in Mice.
    Title: Adipose Triglyceride Lipase Deficiency Aggravates Angiotensin II-Induced Atrial Fibrillation by Reducing Peroxisome Proliferator-Activated Receptor α Activation in Mice.
  9. N-end Rule-Mediated Proteasomal Degradation of ATGL Promotes Lipid Storage.
    Title: N-end Rule-Mediated Proteasomal Degradation of ATGL Promotes Lipid Storage.
  10. Blocking Lipid Uptake Pathways Does not Prevent Toxicity in Adipose Triglyceride Lipase (ATGL) Deficiency.
    Title: Blocking Lipid Uptake Pathways Does not Prevent Toxicity in Adipose Triglyceride Lipase (ATGL) Deficiency.
Submit: New GeneRIF Correction See all GeneRIFs (131)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (5)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acylglycerol O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables diolein transacylation activity ISO
Inferred from Sequence Orthology
more info
  
enables diolein transacylation activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables mono-olein transacylation activity ISO
Inferred from Sequence Orthology
more info
  
enables mono-olein transacylation activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
  
enables phospholipase A2 activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables retinyl-palmitate esterase activity ISO
Inferred from Sequence Orthology
more info
  
enables retinyl-palmitate esterase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables triacylglycerol lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables triacylglycerol lipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables triacylglycerol lipase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables triacylglycerol lipase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in diacylglycerol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular triglyceride homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular triglyceride homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid droplet disassembly IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid droplet disassembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_negative_effect lipid droplet fusion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_negative_effect lipid droplet fusion ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within lipid droplet organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of sequestering of triglyceride IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of sequestering of triglyceride ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of triglyceride catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of triglyceride catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in retinol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in triglyceride catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within triglyceride catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in triglyceride catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
patatin-like phospholipase domain-containing protein 2
Names
adipose triglyceride lipase
calcium-independent phospholipase A2-zeta
desnutrin
iPLA2-zeta
transport-secretion protein
triglyceride hydrolase
NP_001157161.1
NP_080078.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163689.1 → NP_001157161.1  patatin-like phospholipase domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001157161.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK031609, AK076464, BB574719
    Consensus CDS
    CCDS52445.1
    UniProtKB/Swiss-Prot
    O89080, Q05BJ0, Q3UD97, Q643S0, Q6P234, Q8BJ56, Q9D1Q9, Q9DCF6
    Related
    ENSMUSP00000127149.2, ENSMUST00000164016.8
    Conserved Domains (2) summary
    cd07220
    Location:4 → 252
    Pat_PNPLA2; Patatin-like phospholipase domain containing protein 2
    COG1752
    Location:7 → 306
    RssA; Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only]

  2. NM_025802.3 → NP_080078.2  patatin-like phospholipase domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_080078.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AK002826, AK076464, BB574719, CF725975
    Consensus CDS
    CCDS22015.1
    UniProtKB/Swiss-Prot
    Q8BJ56
    Related
    ENSMUSP00000065116.7, ENSMUST00000064151.13
    Conserved Domains (1) summary
    cd07220
    Location:4 → 252
    Pat_PNPLA2; Patatin-like phospholipase domain containing protein 2

RNA

  1. NR_028142.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an additional exon in the 5' region, as compared to variant 1. The resulting transcript is nonsense-mediated mRNA decay candidate and is unlikely to make a functional protein.
    Source sequence(s)
    AC158224

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    141035101..141040656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BJ56.1 GenPept UniProtKB/Swiss-Prot:Q8BJ56

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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