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Alg14 asparagine-linked glycosylation 14 [ Mus musculus (house mouse) ]

Gene ID: 66789, updated on 2-Nov-2024

Summary

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Official Symbol
Alg14provided by MGI
Official Full Name
asparagine-linked glycosylation 14provided by MGI
Primary source
MGI:MGI:1914039
See related
Ensembl:ENSMUSG00000039887 AllianceGenome:MGI:1914039
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5430428G01Rik
Summary
Predicted to enable protein-membrane adaptor activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to act upstream of with a positive effect on protein N-linked glycosylation. Predicted to be part of UDP-N-acetylglucosamine transferase complex. Predicted to be active in cytoplasmic side of endoplasmic reticulum membrane. Is expressed in several structures, including early conceptus; gallbladder; genitourinary system; gut gland; and nervous system. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 15. Orthologous to human ALG14 (ALG14 UDP-N-acetylglucosaminyltransferase subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung adult (RPKM 8.4), subcutaneous fat pad adult (RPKM 8.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Alg14 in Genome Data Viewer
Location:
3 G1; 3 52.94 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (121085361..121156745)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (121291712..121363096)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene TLC domain containing 4 Neighboring gene predicted gene, 52661 Neighboring gene within bgcn homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_08838 Neighboring gene STARR-positive B cell enhancer ABC_E4584 Neighboring gene STARR-positive B cell enhancer mm9_chr3:121010508-121010808 Neighboring gene STARR-positive B cell enhancer ABC_E11213 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:121047938-121048139 Neighboring gene predicted gene, 33310 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:121068079-121068270 Neighboring gene STARR-positive B cell enhancer mm9_chr3:121072387-121072688 Neighboring gene STARR-positive B cell enhancer mm9_chr3:121073107-121073408 Neighboring gene STARR-seq mESC enhancer starr_08839 Neighboring gene predicted gene, 33363 Neighboring gene STARR-seq mESC enhancer starr_08840 Neighboring gene peptidylprolyl isomerase A pseudogene 3_1234.1 Neighboring gene predicted gene, 40134

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-membrane adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-membrane adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in dolichol-linked oligosaccharide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dolichol-linked oligosaccharide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dolichol-linked oligosaccharide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_positive_effect protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_positive_effect protein N-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of UDP-N-acetylglucosamine transferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of UDP-N-acetylglucosamine transferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of UDP-N-acetylglucosamine transferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasmic side of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic side of endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
UDP-N-acetylglucosamine transferase subunit ALG14; UDP-N-acetylglucosamine transferase subunit ALG14 homolog
Names
asparagine-linked glycosylation 14 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024178.3 → NP_077140.1  UDP-N-acetylglucosamine transferase subunit ALG14

    See identical proteins and their annotated locations for NP_077140.1

    Status: VALIDATED

    Source sequence(s)
    AC105336, AC161210
    Consensus CDS
    CCDS17801.1
    UniProtKB/Swiss-Prot
    Q8CEP2, Q9D081
    Related
    ENSMUSP00000038387.8, ENSMUST00000039442.12
    Conserved Domains (1) summary
    pfam08660
    Location:39 → 216
    Alg14; Oligosaccharide biosynthesis protein Alg14 like

RNA

  1. NR_155539.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC105336, AC161210

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    121085361..121156745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501899.3 → XP_006501962.1  UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform X1

    Conserved Domains (1) summary
    pfam08660
    Location:39 → 221
    Alg14; Oligosaccharide biosynthesis protein Alg14 like

RNA

  1. XR_003954370.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D081.1 GenPept UniProtKB/Swiss-Prot:Q9D081

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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