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Pgls 6-phosphogluconolactonase [ Mus musculus (house mouse) ]

Gene ID: 66171, updated on 28-Oct-2024

Summary

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Official Symbol
Pglsprovided by MGI
Official Full Name
6-phosphogluconolactonaseprovided by MGI
Primary source
MGI:MGI:1913421
See related
Ensembl:ENSMUSG00000031807 AllianceGenome:MGI:1913421
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Plgs; 1110030K05Rik
Summary
Predicted to enable 6-phosphogluconolactonase activity and monosaccharide binding activity. Predicted to be involved in pentose-phosphate shunt, oxidative branch. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in cerebellum; hemolymphoid system; and thymus primordium. Orthologous to human PGLS (6-phosphogluconolactonase). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 208.2), ovary adult (RPKM 111.5) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Pgls in Genome Data Viewer
Location:
8 B3.3; 8 34.43 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (72044828..72048911)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71592184..71596267)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene nucleoredoxin-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E10508 Neighboring gene solute carrier family 27 (fatty acid transporter), member 1 Neighboring gene niban apoptosis regulator 3 Neighboring gene STARR-positive B cell enhancer ABC_E9025 Neighboring gene collagen beta(1-O)galactosyltransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. 547 transcriptomes from 44 brain areas reveal features of the aging brain in non-human primates. Li ML, et al. Genome Biol, 2019 Nov 28. PMID 31779658, Free PMC Article
  2. γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A. Gao X, et al. Mol Cell, 2019 Dec 19. PMID 31586547, Free PMC Article
  3. NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase. Miclet E, et al. J Biol Chem, 2001 Sep 14. PMID 11457850
  4. Deciphering the metabolic heterogeneity of hematopoietic stem cells with single-cell resolution. Cao J, et al. Cell Metab, 2024 Jan 2. PMID 38171334
  5. Investigation of differentially expressed genes during the development of mouse cerebellum. Kagami Y, et al. Brain Res Gene Expr Patterns, 2001 Aug. PMID 15018818

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. hub gene underlying brain aging
    Title: 547 transcriptomes from 44 brain areas reveal features of the aging brain in non-human primates.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 6-phosphogluconolactonase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 6-phosphogluconolactonase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables monosaccharide binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt ISO
Inferred from Sequence Orthology
more info
  
involved_in pentose-phosphate shunt, oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pentose-phosphate shunt, oxidative branch ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
6-phosphogluconolactonase
Names
6PGL
NP_001281198.1
NP_079672.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001294269.1 → NP_001281198.1  6-phosphogluconolactonase isoform 2

    See identical proteins and their annotated locations for NP_001281198.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC162033, AK003134, AK003985, BE654173
    Consensus CDS
    CCDS80895.1
    UniProtKB/TrEMBL
    D3Z4X1
    Related
    ENSMUSP00000116524.2, ENSMUST00000143441.2
    Conserved Domains (1) summary
    cd01400
    Location:15 → 156
    6PGL; 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard ...

  2. NM_025396.3 → NP_079672.1  6-phosphogluconolactonase isoform 1

    See identical proteins and their annotated locations for NP_079672.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC162033
    Consensus CDS
    CCDS22400.1
    UniProtKB/Swiss-Prot
    Q3TA62, Q9CQ60
    UniProtKB/TrEMBL
    Q8CBG6
    Related
    ENSMUSP00000034264.5, ENSMUST00000034264.11
    Conserved Domains (1) summary
    TIGR01198
    Location:11 → 247
    pgl; 6-phosphogluconolactonase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    72044828..72048911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQ60.1 GenPept UniProtKB/Swiss-Prot:Q9CQ60

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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