Rtn4r reticulon 4 receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rtn4rprovided by MGI
Official Full Name: reticulon 4 receptorprovided by MGI
Primary source: MGI:MGI:2136886
See related: Ensembl:ENSMUSG00000043811 AllianceGenome:MGI:2136886
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NgR; NgR1; NOGOR
Summary: Enables chondroitin sulfate binding activity; heparin binding activity; and neuregulin receptor activity. Involved in several processes, including negative regulation of neuron projection development; neuronal signal transduction; and regulation of postsynapse assembly. Acts upstream of or within axonogenesis. Located in several cellular components, including axonal growth cone; dendritic shaft; and neuronal cell body. Is active in glutamatergic synapse. Is expressed in several structures, including cardiovascular system; forelimb bud; intestine; male reproductive gland or organ; and nervous system. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human RTN4R (reticulon 4 receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cortex adult (RPKM 55.4), frontal lobe adult (RPKM 33.2) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A3; 16 11.23 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (17945506..17970272)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (18127642..18152408)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Viral capsid structural assembly governs the reovirus binding interface to NgR1.
Title: Viral capsid structural assembly governs the reovirus binding interface to NgR1.
PD-1 deficiency aggravates spinal cord injury by regulating the reprogramming of NG2 glia and activating the NgR/RhoA/ROCK signaling pathway.
Title: PD-1 deficiency aggravates spinal cord injury by regulating the reprogramming of NG2 glia and activating the NgR/RhoA/ROCK signaling pathway.
Reduction of NgR in perforant path protects neuronal morphology and function in APP/PS1 transgenic mice.
Title: Reduction of NgR in perforant path protects neuronal morphology and function in APP/PS1 transgenic mice.
The Murine Neuronal Receptor NgR1 Is Dispensable for Reovirus Pathogenesis.
Title: The Murine Neuronal Receptor NgR1 Is Dispensable for Reovirus Pathogenesis.
Role of Nogo Receptor-1 for Recovery of Balance, Cognition, and Emotion after Mild Traumatic Brain Injury in Mice.
Title: Role of Nogo Receptor-1 for Recovery of Balance, Cognition, and Emotion after Mild Traumatic Brain Injury in Mice.
NgR1 governs axonal degeneration in the context of inflammatory-mediated demyelination through the phosphorylation of CRMP2 by stalling axonal vesicular transport. ngr1 deletion preserves axonal transport.
Title: Limiting Neuronal Nogo Receptor 1 Signaling during Experimental Autoimmune Encephalomyelitis Preserves Axonal Transport and Abrogates Inflammatory Demyelination.
Here, biochemical analysis of NgR1 function uncovered a physical complex with CRMP cytoplasmic mediators, and this led to appreciation of a role for PlexinA2 in concert with NgR1 after adult spinal cord trauma.
Title: Plexina2 and CRMP2 Signaling Complex Is Activated by Nogo-A-Liganded Ngr1 to Restrict Corticospinal Axon Sprouting after Trauma.
interacts with voltage-gated CaV2.2 calcium channels
Title: Four novel interaction partners demonstrate diverse modulatory effects on voltage-gated Ca(V)2.2 Ca(2+) channels.
These data suggest that NgR1 may regulate axo-myelin ultrastructure through Caspr-mediated adhesion, regulating the electrophysiological signature of myelinated axons of central nervous system.
Title: Nogo receptor 1 regulates Caspr distribution at axo-glial units in the central nervous system.
Nogo-A and NgR1 interactions may contribute to axonal branching in lateral olfactory tract development
Title: Axonal branching in lateral olfactory tract is promoted by Nogo signaling.

Submit: New GeneRIF Correction See all GeneRIFs (63)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (3)
Targeted (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rtn4r (e-PCR), detects polymorphism
- UniSTS:265745

Rtn4r (e-PCR), detects polymorphism
- UniSTS:547533

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Roundabout binding	IBA Inferred from Biological aspect of Ancestor more info
enables chondroitin sulfate binding	IDA Inferred from Direct Assay more info	PubMed
enables ganglioside GM1 binding	ISO Inferred from Sequence Orthology more info
enables ganglioside GM1 binding	ISS Inferred from Sequence or Structural Similarity more info
enables ganglioside GT1b binding	ISO Inferred from Sequence Orthology more info
enables ganglioside GT1b binding	ISS Inferred from Sequence or Structural Similarity more info
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables neuregulin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axonogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in corpus callosum development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of axon extension	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuronal signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Rho protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynapse assembly	EXP Inferred from Experiment more info	PubMed
involved_in regulation of postsynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: reticulon-4 receptor

Names: nogo66 receptor-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022982.3 → NP_075358.1 reticulon-4 receptor precursor

See identical proteins and their annotated locations for NP_075358.1

Status: VALIDATED

Source sequence(s)

AC087064, AC118542

Consensus CDS

CCDS37279.1

UniProtKB/Swiss-Prot

Q80WQ1, Q99PI8

Related

ENSMUSP00000062924.6, ENSMUST00000059589.6

Conserved Domains (4) summary

cd00116
Location:90 → 166

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:60 → 82

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:156 → 195

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:131 → 190

LRR_8; Leucine rich repeat