Serpina5 serpin family A member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Serpina5provided by RGD
Official Full Name: serpin family A member 5provided by RGD
Primary source: RGD:619817
See related: EnsemblRapid:ENSRNOG00000009855 AllianceGenome:RGD:619817
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pci
Summary: Enables serine-type endopeptidase inhibitor activity. Involved in negative regulation of proteolysis and seminal vesicle development. Predicted to be located in several cellular components, including external side of plasma membrane; extracellular exosome; and secretory granule. Predicted to be part of several cellular components, including protein C inhibitor-KLK3 complex; protein C inhibitor-PLAT complex; and protein C inhibitor-PLAU complex. Predicted to be active in extracellular space. Orthologous to human SERPINA5 (serpin family A member 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 127.8) and Liver (RPKM 71.9) See more
Orthologs: human all
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Genomic context

Location:: 6q32

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (128774006..128793187)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (123009224..123028412)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (127753152..127772403)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Improvement in Clinical Features of L-NAME-Induced Preeclampsia-like Rats through Reduced SERPINA5 Expression.
Title: Improvement in Clinical Features of L-NAME-Induced Preeclampsia-like Rats through Reduced SERPINA5 Expression.
Proteomic analysis of human articular cartilage unravels the dyscoagulation in osteoarthritis and the potential value of serpinA5 as a biomarker for osteoarthritis.
Title: Proteomic analysis of human articular cartilage unravels the dyscoagulation in osteoarthritis and the potential value of serpinA5 as a biomarker for osteoarthritis.
PCI in testis is expressed by Sertoli cells; testicular expression of PCI is responsive to intratesticular testosterone;protease activity in seminiferous epithelium is elevated when intratesticular concentration is decreased, as a result of decreased PCI.
Title: Protein C inhibitor expression by adult rat Sertoli cells: effects of testosterone withdrawal and replacement.

Submit: New GeneRIF Correction

General gene information

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Markers

BI280884 (e-PCR)
- UniSTS:249061

BE121264 (e-PCR)
- UniSTS:248052

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acrosin binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables retinoic acid binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of hydrolase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in seminal vesicle development	IEP Inferred from Expression Pattern more info	PubMed
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in acrosomal membrane	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in platelet alpha granule	ISO Inferred from Sequence Orthology more info
located_in platelet dense tubular network	ISO Inferred from Sequence Orthology more info
part_of protein C inhibitor-KLK3 complex	ISO Inferred from Sequence Orthology more info
part_of protein C inhibitor-PLAT complex	ISO Inferred from Sequence Orthology more info
part_of protein C inhibitor-PLAU complex	ISO Inferred from Sequence Orthology more info
part_of protein C inhibitor-TMPRSS11E complex	ISO Inferred from Sequence Orthology more info
part_of protein C inhibitor-TMPRSS7 complex	ISO Inferred from Sequence Orthology more info
part_of protein C inhibitor-coagulation factor V complex	ISO Inferred from Sequence Orthology more info
part_of protein C inhibitor-coagulation factor XI complex	ISO Inferred from Sequence Orthology more info
part_of protein C inhibitor-coagulation factor Xa complex	ISO Inferred from Sequence Orthology more info
part_of protein C inhibitor-plasma kallikrein complex	ISO Inferred from Sequence Orthology more info
part_of protein C inhibitor-thrombin complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: plasma serine protease inhibitor

Names: protein C inhibitor; serine (or cysteine) peptidase inhibitor, clade A, member 5; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5; serpin peptidase inhibitor, clade A, member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001244739.1 → NP_001231668.1 plasma serine protease inhibitor isoform 1

See identical proteins and their annotated locations for NP_001231668.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) is the shorter transcript but encodes the longer isoform (1).

Source sequence(s)

BC081797, CK603584

UniProtKB/TrEMBL

A6JEQ3, Q66HL5

Related

ENSRNOP00000106495.1, ENSRNOT00000127466.1

Conserved Domains (1) summary

cd02056
Location:81 → 439

alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...
NM_022957.3 → NP_075246.3 plasma serine protease inhibitor isoform 2 precursor

See identical proteins and their annotated locations for NP_075246.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate splice junction in the 5' region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.

Source sequence(s)

BC097315, CK603584

UniProtKB/TrEMBL

F7EMJ6, Q66HL5

Related

ENSRNOP00000013138.5, ENSRNOT00000013138.8

Conserved Domains (1) summary

cl38926
Location:47 → 410

serpin; SERine Proteinase INhibitors (serpin) family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

128774006..128793187

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240494.5 → XP_006240556.1 plasma serine protease inhibitor isoform X1

See identical proteins and their annotated locations for XP_006240556.1

UniProtKB/TrEMBL

F7EMJ6, Q66HL5

Conserved Domains (1) summary

cl38926
Location:47 → 410

serpin; SERine Proteinase INhibitors (serpin) family
XM_017594349.3 → XP_017449838.1 plasma serine protease inhibitor isoform X1

UniProtKB/TrEMBL

F7EMJ6, Q66HL5

Conserved Domains (1) summary

cl38926
Location:47 → 410

serpin; SERine Proteinase INhibitors (serpin) family
XM_039112916.2 → XP_038968844.1 plasma serine protease inhibitor isoform X1

UniProtKB/TrEMBL

F7EMJ6, Q66HL5

Conserved Domains (1) summary

cl38926
Location:47 → 410

serpin; SERine Proteinase INhibitors (serpin) family