Pdzd2 PDZ domain containing 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Pdzd2provided by RGD
Full Name: PDZ domain containing 2provided by RGD
Primary source: RGD:619958
See related: EnsemblRapid:ENSRNOG00000013140 AllianceGenome:RGD:619958
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Papin; Pdzk3
Summary: Predicted to be involved in intracellular signal transduction. Located in several cellular components, including apical part of cell; cell-cell junction; and endoplasmic reticulum. Orthologous to human PDZD2 (PDZ domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 232.3), Heart (RPKM 128.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q16

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (63111650..63497520, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (61384614..61770516, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (62399748..62520448, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Secreted PDZD2 exerts an insulinotropic effect on INS-1E cells by a PKA-dependent mechanism.
Title: Secreted PDZD2 exerts an insulinotropic effect on INS-1E cells by a PKA-dependent mechanism.
These findings reveal that Pdzd2 and p11 play collaborative roles in regulation of Na(V)1.8 expression in sensory neurons.
Title: A multi PDZ-domain protein Pdzd2 contributes to functional expression of sensory neuron-specific sodium channel Na(V)1.8.

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General gene information

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Markers

D2Mit4 (e-PCR), detects polymorphism
- UniSTS:119371

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: PDZ domain-containing protein 2

Names: PDZ domain containing 3; PDZ domain-containing protein 3; plakophilin-related armadillo repeat protein-interacting PDZ protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022940.2 → NP_075229.2 PDZ domain-containing protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8I6AIY0

Related

ENSRNOP00000093111.1, ENSRNOT00000108989.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

63111650..63497520 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103091.2 → XP_038959019.1 PDZ domain-containing protein 2 isoform X3

UniProtKB/TrEMBL

A6KJP6

Conserved Domains (3) summary

smart00228
Location:2587 → 2669

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:841 → 1302

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:446 → 527

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_039103090.2 → XP_038959018.1 PDZ domain-containing protein 2 isoform X2

UniProtKB/TrEMBL

A6KJP6

Conserved Domains (3) summary

smart00228
Location:2639 → 2721

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:893 → 1354

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:498 → 579

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_039103085.2 → XP_038959013.1 PDZ domain-containing protein 2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZMB2, A6KJP6

Related

ENSRNOP00000079233.1, ENSRNOT00000105047.2

Conserved Domains (2) summary

PHA03247
Location:985 → 1446

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:590 → 671

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_039103086.2 → XP_038959014.1 PDZ domain-containing protein 2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZMB2, A6KJP6

Conserved Domains (2) summary

PHA03247
Location:985 → 1446

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:590 → 671

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_039103088.2 → XP_038959016.1 PDZ domain-containing protein 2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZMB2, A6KJP6

Conserved Domains (2) summary

PHA03247
Location:985 → 1446

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:590 → 671

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_039103087.2 → XP_038959015.1 PDZ domain-containing protein 2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZMB2, A6KJP6

Conserved Domains (2) summary

PHA03247
Location:985 → 1446

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:590 → 671

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_063282504.1 → XP_063138574.1 PDZ domain-containing protein 2 isoform X4
XM_039103093.2 → XP_038959021.1 PDZ domain-containing protein 2 isoform X4

UniProtKB/TrEMBL

A6KJQ0

Conserved Domains (2) summary

PHA03247
Location:811 → 1272

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:416 → 497

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_039103094.2 → XP_038959022.1 PDZ domain-containing protein 2 isoform X4

UniProtKB/TrEMBL

A6KJQ0

Related

ENSRNOP00000017937.5, ENSRNOT00000017937.5

Conserved Domains (2) summary

PHA03247
Location:811 → 1272

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:416 → 497

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...